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Chmelař J, Chatzigeorgiou A, Chung KJ, et al. No Role for Mast Cells in Obesity-Related Metabolic Dysregulation. Front Immunol. 2016;7:524doi: 10.3389/fimmu.2016.00524.
Chmelař, J., Chatzigeorgiou, A., Chung, K. J., Prucnal, M., Voehringer, D., Roers, A., & Chavakis, T. (2016). No Role for Mast Cells in Obesity-Related Metabolic Dysregulation. Frontiers in immunology, 7524. https://doi.org/10.3389/fimmu.2016.00524
Chmelař, Jindřich, et al. "No Role for Mast Cells in Obesity-Related Metabolic Dysregulation." Frontiers in immunology vol. 7 (2016): 524. doi: https://doi.org/10.3389/fimmu.2016.00524
Chmelař J, Chatzigeorgiou A, Chung KJ, Prucnal M, Voehringer D, Roers A, Chavakis T. No Role for Mast Cells in Obesity-Related Metabolic Dysregulation. Front Immunol. 2016 Nov 24;7:524. doi: 10.3389/fimmu.2016.00524. eCollection 2016. PMID: 27933062; PMCID: PMC5121122.
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Front Immunol. 2016 Nov 24;7:524. doi: 10.3389/fimmu.2016.00524. eCollection 2016.

No Role for Mast Cells in Obesity-Related Metabolic Dysregulation.

Frontiers in immunology

Jindřich Chmelař, Antonios Chatzigeorgiou, Kyoung-Jin Chung, Marta Prucnal, David Voehringer, Axel Roers, Triantafyllos Chavakis

Affiliations

  1. Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden, Dresden, Germany; Faculty of Science, University of South Bohemia in ?eské Bud?jovice, ?eské Bud?jovice, Czech Republic.
  2. Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden, Dresden, Germany; Medical Faculty, Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
  3. Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
  4. Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden , Dresden , Germany.
  5. Department of Infection Biology, Universitätsklinikum Erlangen at the Friedrich-Alexander Universität Erlangen-Nürnberg (FAU) , Erlangen , Germany.
  6. Institute for Immunology, Technische Universität Dresden , Dresden , Germany.
  7. Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden, Dresden, Germany; Medical Faculty, Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.

PMID: 27933062 PMCID: PMC5121122 DOI: 10.3389/fimmu.2016.00524

Abstract

Obesity-related adipose tissue (AT) inflammation that promotes metabolic dysregulation is associated with increased AT mast cell numbers. Mast cells are potent inducers of inflammatory responses and could potentially contribute to obesity-induced AT inflammation and metabolic dysregulation. Conflicting findings were reported on obesity-related metabolic dysfunction in mast cell-deficient mice, thus creating a controversy that has not been resolved to date. Whereas traditional

Keywords: diet-induced obesity; glucose tolerance; insulin resistance; mast cell deficiency; metabolic dysregulation

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