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Oliveira EH, Macedo C, Collares CV, et al. Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells. Front Immunol. 2016;7:526doi: 10.3389/fimmu.2016.00526.
Oliveira, E. H., Macedo, C., Collares, C. V., Freitas, A. C., Donate, P. B., Sakamoto-Hojo, E. T., Donadi, E. A., & Passos, G. A. (2016). Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells. Frontiers in immunology, 7526. https://doi.org/10.3389/fimmu.2016.00526
Oliveira, Ernna H, et al. "Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells." Frontiers in immunology vol. 7 (2016): 526. doi: https://doi.org/10.3389/fimmu.2016.00526
Oliveira EH, Macedo C, Collares CV, Freitas AC, Donate PB, Sakamoto-Hojo ET, Donadi EA, Passos GA. Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells. Front Immunol. 2016 Nov 23;7:526. doi: 10.3389/fimmu.2016.00526. eCollection 2016. PMID: 27933063; PMCID: PMC5120147.
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Front Immunol. 2016 Nov 23;7:526. doi: 10.3389/fimmu.2016.00526. eCollection 2016.

Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.

Frontiers in immunology

Ernna H Oliveira, Claudia Macedo, Cristhianna V Collares, Ana Carolina Freitas, Paula Barbim Donate, Elza T Sakamoto-Hojo, Eduardo A Donadi, Geraldo A Passos

Affiliations

  1. Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
  2. Department of Pathology, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
  3. Department of Biology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo (USP) , São Paulo , Brazil.
  4. Department of Clinical Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo (USP) , São Paulo , Brazil.
  5. Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil; Discipline of Genetics and Molecular Biology, Department of Morphology, Physiology and Basic Pathology, School of Dentistry of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.

PMID: 27933063 PMCID: PMC5120147 DOI: 10.3389/fimmu.2016.00526

Abstract

Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream posttranscriptional controller in these cells and that variation in its expression might be associated with changes in the interactions between miRNAs and the mRNAs encoding PTAs. We demonstrated that downregulation of Aire

Keywords: Aire; in vivo gene knockdown; medullary thymic epithelial cells; miRNAs; miRNA–mRNA interaction; promiscuous gene expression

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