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Bardawil T, Khalil S, Bergqvist C, et al. Genetics of inherited cardiocutaneous syndromes: a review. Open Heart. 2016;3(2):e000442doi: 10.1136/openhrt-2016-000442.
Bardawil, T., Khalil, S., Bergqvist, C., Abbas, O., Kibbi, A. G., Bitar, F., Nemer, G., & Kurban, M. (2016). Genetics of inherited cardiocutaneous syndromes: a review. Open heart, 3(2), e000442. https://doi.org/10.1136/openhrt-2016-000442
Bardawil, Tara, et al. "Genetics of inherited cardiocutaneous syndromes: a review." Open heart vol. 3,2 (2016): e000442. doi: https://doi.org/10.1136/openhrt-2016-000442
Bardawil T, Khalil S, Bergqvist C, Abbas O, Kibbi AG, Bitar F, Nemer G, Kurban M. Genetics of inherited cardiocutaneous syndromes: a review. Open Heart. 2016 Nov 22;3(2):e000442. doi: 10.1136/openhrt-2016-000442. eCollection 2016. PMID: 27933191; PMCID: PMC5133403.
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Open Heart. 2016 Nov 22;3(2):e000442. doi: 10.1136/openhrt-2016-000442. eCollection 2016.

Genetics of inherited cardiocutaneous syndromes: a review.

Open heart

Tara Bardawil, Samar Khalil, Christina Bergqvist, Ossama Abbas, Abdul Ghani Kibbi, Fadi Bitar, Georges Nemer, Mazen Kurban

Affiliations

  1. American University of Beirut , Beirut Lebanon.
  2. Department of Dermatology , American University of Beirut , Beirut Lebanon.
  3. Department of Biochemistry and Molecular Genetics, American University of Beirut, BeirutLebanon; Department of Pediatrics, American University of Beirut, BeirutLebanon.
  4. Department of Biochemistry and Molecular Genetics , American University of Beirut , Beirut Lebanon.
  5. Department of Dermatology, American University of Beirut, BeirutLebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, BeirutLebanon; Department of Dermatology, Columbia University Medical Center, New York, New York, USA.

PMID: 27933191 PMCID: PMC5133403 DOI: 10.1136/openhrt-2016-000442

Abstract

The life of a human being originates as a single cell which, under the influence of certain factors, divides sequentially into multiple cells that subsequently become committed to develop and differentiate into the different structures and organs. Alterations occurring early on in the development process may lead to fetal demise in utero. Conversely, abnormalities at later stages may result in structural and/or functional abnormalities of varying severities. The cardiovascular system and skin share certain developmental and structural factors; therefore, it is not surprising to find several inherited syndromes with both cardiac and skin manifestations. Here, we will review the overlapping pathways in the development of the skin and heart, as well as the resulting syndromes. We will also highlight several cutaneous clues that may help physicians screen and uncover cardiac anomalies that may be otherwise hidden and result in sudden cardiac death.

Keywords: Cardiocutaneous; Congenital; Dermatologic; Syndromes

Conflict of interest statement

Conflicts of Interest: None declared.

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