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Moradi F, Jahanian Sadatmahalleh S, Ziaei S. The effect of hormone replacement therapy on cognitive function in postmenopausal women: An RCT. Int J Reprod Biomed. 2019;16(12)doi: 10.18502/ijrm.v16i12.3682.
Moradi, F., Jahanian Sadatmahalleh, S., & Ziaei, S. (2018). The effect of hormone replacement therapy on cognitive function in postmenopausal women: An RCT. International journal of reproductive biomedicine, 16(12), . https://doi.org/10.18502/ijrm.v16i12.3682
Moradi, Fereshteh, et al. "The effect of hormone replacement therapy on cognitive function in postmenopausal women: An RCT." International journal of reproductive biomedicine vol. 16,12 (2018). doi: https://doi.org/10.18502/ijrm.v16i12.3682
Moradi F, Jahanian Sadatmahalleh S, Ziaei S. The effect of hormone replacement therapy on cognitive function in postmenopausal women: An RCT. Int J Reprod Biomed. 2019 Jan 28;16(12). doi: 10.18502/ijrm.v16i12.3682. eCollection 2018 Dec. PMID: 31417982; PMCID: PMC6600282.
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Int J Reprod Biomed. 2019 Jan 28;16(12). doi: 10.18502/ijrm.v16i12.3682. eCollection 2018 Dec.

The effect of hormone replacement therapy on cognitive function in postmenopausal women: An RCT.

International journal of reproductive biomedicine

Fereshteh Moradi, Shahideh Jahanian Sadatmahalleh, Saeideh Ziaei

Affiliations

  1. Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

PMID: 31417982 PMCID: PMC6600282 DOI: 10.18502/ijrm.v16i12.3682

Abstract

BACKGROUND: During the reproductive age, the human brain becomes a target for gonadal steroid hormones. Estrogens influence neural function through effects on neurons and affects indirectly the oxidative stress, inflammation, the cerebral vascular and the immune system.

OBJECTIVE: To evaluate the effect of the traditional hormone replacement therapy (HRT) on the cognitive function in postmenopausal women.

MATERIALS AND METHODS: In this randomized clinical trial, 140 postmenopausal women, from November 2014 to February 2015, were included. Women were randomly divided into two groups. Each woman in the case group took traditional HRT (0.625mg conjugated equine estrogens+2.5mg medroxyprogesterone acetate daily) plus one Cal+D tablet (500 mg calcium+200 IU vitamin D) daily for four months. Women in the control group received only one Cal+D tablet (500 mg calcium+200 IU vitamin D) daily for four months period. The Montreal Cognitive Assessment (MoCA) and Green Climacteric Scale (GCS) questionnaires filled out after the intervention and compared between the two groups.

RESULTS: The mean points of the MoCA after the intervention indicate that all MoCA domains except for the orientation improved in the case group. There was a significant difference in the memory domain after the treatment between the two groups. MoCA domains and GCS were negatively correlated after the intervention (

CONCLUSION: The HRT has affected some of the MoCA factors. The effects of HRT on cognitive function should be studied in a large prospective study in a group of women in their early and late menopausal ages with periodic assessment of their cognitive function during these follow-up years.

Keywords: Hormone replacement therapy; Postmenopausal women.; Cognition

Conflict of interest statement

The authors have no conflicts of interest.

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