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MacLeod R, Hillert EK, Cameron RT, et al. The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease. Future Sci OA. 2015;1(3):FSO11doi: 10.4155/fso.15.9.
MacLeod, R., Hillert, E. K., Cameron, R. T., & Baillie, G. S. (2015). The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease. Future science OA, 1(3), FSO11. https://doi.org/10.4155/fso.15.9
MacLeod, Ruth, et al. "The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease." Future science OA vol. 1,3 (2015): FSO11. doi: https://doi.org/10.4155/fso.15.9
MacLeod R, Hillert EK, Cameron RT, Baillie GS. The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease. Future Sci OA. 2015 Nov 01;1(3):FSO11. doi: 10.4155/fso.15.9. eCollection 2015 Nov. PMID: 28031886; PMCID: PMC5137966.
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Future Sci OA. 2015 Nov 01;1(3):FSO11. doi: 10.4155/fso.15.9. eCollection 2015 Nov.

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease.

Future science OA

Ruth MacLeod, Ellin-Kristina Hillert, Ryan T Cameron, George S Baillie

Affiliations

  1. Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

PMID: 28031886 PMCID: PMC5137966 DOI: 10.4155/fso.15.9

Abstract

Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main pathological features of AD is the presence in the brain of senile plaques mainly composed of aggregated β amyloid (Aβ), a derivative of the longer amyloid precursor protein (APP). The amyloid hypothesis proposes that the accumulation of Aβ within neural tissue is the initial event that triggers the disease. Here we review research efforts that have attempted to inhibit the generation of the Aβ peptide through modulation of the activity of the proteolytic secretases that act on APP and discuss whether this is a viable therapeutic strategy for treating AD.

Keywords: Alzheimer's disease; alpha; amyloid hypothesis; beta; beta amyloid; gamma; secretase

Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with th

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