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Pincherle A, Jöhr J, Pancini L, et al. Intensive Care Admission and Early Neuro-Rehabilitation. Lessons for COVID-19?. Front Neurol. 2020;11:880doi: 10.3389/fneur.2020.00880.
Pincherle, A., Jöhr, J., Pancini, L., Leocani, L., Dalla Vecchia, L., Ryvlin, P., Schiff, N. D., & Diserens, K. (2020). Intensive Care Admission and Early Neuro-Rehabilitation. Lessons for COVID-19?. Frontiers in neurology, 11880. https://doi.org/10.3389/fneur.2020.00880
Pincherle, Alessandro, et al. "Intensive Care Admission and Early Neuro-Rehabilitation. Lessons for COVID-19?." Frontiers in neurology vol. 11 (2020): 880. doi: https://doi.org/10.3389/fneur.2020.00880
Pincherle A, Jöhr J, Pancini L, Leocani L, Dalla Vecchia L, Ryvlin P, Schiff ND, Diserens K. Intensive Care Admission and Early Neuro-Rehabilitation. Lessons for COVID-19?. Front Neurol. 2020 Aug 25;11:880. doi: 10.3389/fneur.2020.00880. eCollection 2020. PMID: 32982916; PMCID: PMC7477378.
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Front Neurol. 2020 Aug 25;11:880. doi: 10.3389/fneur.2020.00880. eCollection 2020.

Intensive Care Admission and Early Neuro-Rehabilitation. Lessons for COVID-19?.

Frontiers in neurology

Alessandro Pincherle, Jane Jöhr, Lisa Pancini, Letizia Leocani, Laura Dalla Vecchia, Philippe Ryvlin, Nicholas D Schiff, Karin Diserens

Affiliations

  1. Acute Neuro-Rehabilitation Unit and Neurology Unit, Department of Clinical Neurosciences, Lausanne University Hospital-CHUV, Lausanne, Switzerland.
  2. Neurology Unit, Department of Medicine, Hopitaux Robert Schuman-Luxembourg, Luxembourg, Luxembourg.
  3. Departments of Cardiac and Pulmonary Rehabilitation, IRCSS Istituto Clinico Scientifico Maugeri, Milan, Italy.
  4. Department of Neuro-Rehabilitation, Hospital San Raffaele, University Vita Salute, Milan, Italy.
  5. Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States.

PMID: 32982916 PMCID: PMC7477378 DOI: 10.3389/fneur.2020.00880

Abstract

Coronavirus disease 2019 (COVID-19) requires admission to intensive care (ICU) for the management of acute respiratory distress syndrome in about 5% of cases. Although our understanding of COVID-19 is still incomplete, a growing body of evidence is indicating potential direct deleterious effects on the central and peripheral nervous systems. Indeed, complex and long-lasting physical, cognitive, and functional impairments have often been observed after COVID-19. Early (defined as during and immediately after ICU discharge) rehabilitative interventions are fundamental for reducing the neurological burden of a disease that already heavily affects lung function with pulmonary fibrosis as a possible long-term consequence. In addition, ameliorating neuromuscular weakness with early rehabilitation would improve the efficiency of respiratory function as respiratory muscle atrophy worsens lung capacity. This review briefly summarizes the polymorphic burden of COVID-19 and addresses possible early interventions that could minimize the neurological and systemic impact. In fact, the benefits of early multidisciplinary rehabilitation after an ICU stay have been shown to be advantageous in several clinical conditions making an early rehabilitative approach generalizable and desirable to physicians from a wide range of different specialties.

Copyright © 2020 Pincherle, Jöhr, Pancini, Leocani, Dalla Vecchia, Ryvlin, Schiff and Diserens.

Keywords: COVID-19; ICU; early rehabilitation; immobilization; mechanical ventilation; neurological complications

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