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Zhou Y, Yu N, Zhao J, et al. Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine. Front Cell Dev Biol. 2020;8:765doi: 10.3389/fcell.2020.00765.
Zhou, Y., Yu, N., Zhao, J., Xie, Z., Yang, Z., & Tian, B. (2020). Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine. Frontiers in cell and developmental biology, 8765. https://doi.org/10.3389/fcell.2020.00765
Zhou, Yulong, et al. "Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine." Frontiers in cell and developmental biology vol. 8 (2020): 765. doi: https://doi.org/10.3389/fcell.2020.00765
Zhou Y, Yu N, Zhao J, Xie Z, Yang Z, Tian B. Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine. Front Cell Dev Biol. 2020 Aug 31;8:765. doi: 10.3389/fcell.2020.00765. eCollection 2020. PMID: 32984309; PMCID: PMC7487321.
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Front Cell Dev Biol. 2020 Aug 31;8:765. doi: 10.3389/fcell.2020.00765. eCollection 2020.

Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine.

Frontiers in cell and developmental biology

Yulong Zhou, Ning Yu, Jie Zhao, Zhenming Xie, Zhaonan Yang, Bing Tian

Affiliations

  1. Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China.
  2. MOE Key Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.
  3. Department of Applied Biological Science, Zhejiang University, Hangzhou, China.

PMID: 32984309 PMCID: PMC7487321 DOI: 10.3389/fcell.2020.00765

Abstract

Plasmalogens are a special class of polar glycerolipids containing a vinyl-ether bond and an ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively. In animals, impaired biosynthesis and regulation of plasmalogens may lead to certain neurological and metabolic diseases. Plasmalogens deficiency was proposed to be strongly associated with neurodegenerative and metabolic diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), and appropriate supplement of plasmalogens could help to prevent and possibly provide therapy of these diseases. Plasmalogens evolved first in anaerobic bacteria with an anaerobic biosynthetic pathway. Later, an oxygen-dependent biosynthesis of plasmalogens appeared in animal cells. This review summarizes and updates current knowledge of anaerobic and aerobic pathways of plasmalogens biosynthesis, including the enzymes involved, steps and aspects of the regulation of these processes. Strategies for increasing the expression of plasmalogen synthetic genes using synthetic biology techniques under specific conditions are discussed. Deep understanding of plasmalogens biosynthesis will provide the bases for the use of plasmalogens and their precursors as potential therapeutic regimens for age-related degenerative and metabolic diseases.

Copyright © 2020 Zhou, Yu, Zhao, Xie, Yang and Tian.

Keywords: aging disease; anaerobic; biosynthesis; oxygen-dependent; plasmalogens

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