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Ramphal B, DeSerisy M, Pagliaccio D, et al. Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status. Cereb Cortex Commun. 2020;1(1):tgaa033doi: 10.1093/texcom/tgaa033.
Ramphal, B., DeSerisy, M., Pagliaccio, D., Raffanello, E., Rauh, V., Tau, G., Posner, J., Marsh, R., & Margolis, A. E. (2020). Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status. Cerebral cortex communications, 1(1), tgaa033. https://doi.org/10.1093/texcom/tgaa033
Ramphal, Bruce, et al. "Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status." Cerebral cortex communications vol. 1,1 (2020): tgaa033. doi: https://doi.org/10.1093/texcom/tgaa033
Ramphal B, DeSerisy M, Pagliaccio D, Raffanello E, Rauh V, Tau G, Posner J, Marsh R, Margolis AE. Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status. Cereb Cortex Commun. 2020;1(1):tgaa033. doi: 10.1093/texcom/tgaa033. Epub 2020 Jul 23. PMID: 32984815; PMCID: PMC7503474.
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Cereb Cortex Commun. 2020;1(1):tgaa033. doi: 10.1093/texcom/tgaa033. Epub 2020 Jul 23.

Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status.

Cerebral cortex communications

Bruce Ramphal, Mariah DeSerisy, David Pagliaccio, Elizabeth Raffanello, Virginia Rauh, Gregory Tau, Jonathan Posner, Rachel Marsh, Amy E Margolis

Affiliations

  1. New York State Psychiatric Institute and Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  2. Department of Psychology, Fordham University, Bronx, NY 10458, USA.
  3. Department of Population and Family Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.

PMID: 32984815 PMCID: PMC7503474 DOI: 10.1093/texcom/tgaa033

Abstract

Although severe early life stress has been shown to accelerate the development of frontolimbic resting-state functional connectivity (RSFC), less is known about the effects of socioeconomic disadvantage, a prolonged and multifaceted stressor. In a cross-sectional study of 127 participants aged 5-25, we examined whether lower neighborhood socioeconomic status (SES; measured by Area Deprivation Index and neighborhood poverty and educational attainment) was associated with prematurely reduced amygdala-ventromedial prefrontal cortex (vmPFC) RSFC. We further tested whether neighborhood SES was more predictive than household SES and whether SES effects on connectivity were associated with anxiety symptoms. We found reduced basolateral amygdala-vmPFC RSFC at earlier ages in participants from more disadvantaged neighborhoods; this effect was unique to neighborhood SES and absent for household SES. Furthermore, this reduced connectivity in more disadvantaged youth and increased connectivity in more advantaged youth were associated with less anxiety; children who deviated from the connectivity pattern associated with their neighborhood SES had more anxiety. These results demonstrate that neighborhood socioeconomic disadvantage is associated with accelerated maturation of amygdala-vmPFC RSFC and suggest that the pathophysiology of pediatric anxiety depends on a child's neighborhood socioeconomic characteristics. Our findings also underscore the importance of examining SES effects in studies of brain development.

© The Author(s) 2020. Published by Oxford University Press.

Keywords: anxiety; brain development; fMRI; functional connectivity; stress acceleration

References

  1. Front Hum Neurosci. 2013 Jul 05;7:313 - PubMed
  2. Curr Dir Psychol Sci. 2006 Aug;15(4):188-192 - PubMed
  3. Psychosom Med. 2006 May-Jun;68(3):414-20 - PubMed
  4. Epigenetics. 2017 Aug;12(8):662-673 - PubMed
  5. JAMA. 2003 Oct 15;290(15):2023-9 - PubMed
  6. Biol Mood Anxiety Disord. 2014 Dec 09;4(1):15 - PubMed
  7. Psychoneuroendocrinology. 2016 Mar;65:9-14 - PubMed
  8. Clin Psychol Sci. 2016 May;4(3):511-526 - PubMed
  9. Matern Child Health J. 2011 Nov;15(8):1195-202 - PubMed
  10. Biol Psychiatry. 2018 Jan 15;83(2):109-119 - PubMed
  11. Psychosom Med. 2018 Jun;80(5):492-501 - PubMed
  12. Am J Public Health. 2012 Sep;102(9):1706-14 - PubMed
  13. Ann N Y Acad Sci. 2010 Feb;1186:223-39 - PubMed
  14. Cereb Cortex. 2020 Jan 10;30(1):1-19 - PubMed
  15. Neuron. 2017 Sep 27;96(1):56-71 - PubMed
  16. Front Cell Neurosci. 2017 Apr 19;11:87 - PubMed
  17. Biol Psychiatry. 2014 Jun 1;75(11):892-900 - PubMed
  18. Dev Psychopathol. 2019 Aug;31(3):1053-1066 - PubMed
  19. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6545-9 - PubMed
  20. Child Dev. 2003 Jan-Feb;74(1):127-43 - PubMed
  21. Trends Cogn Sci. 2009 Feb;13(2):65-73 - PubMed
  22. Annu Rev Psychol. 2002;53:371-99 - PubMed
  23. Neuroscience. 2008 Oct 28;156(4):1103-10 - PubMed
  24. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 May;1(3):253-261 - PubMed
  25. Biol Psychiatry. 2015 Feb 15;77(4):314-23 - PubMed
  26. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:152-160 - PubMed
  27. Nat Commun. 2017 Oct 12;8(1):874 - PubMed
  28. Anat Embryol (Berl). 2005 Dec;210(5-6):343-52 - PubMed
  29. Neuroimage. 2007 Aug 1;37(1):90-101 - PubMed
  30. Psychol Med. 2003 Nov;33(8):1341-55 - PubMed
  31. Neuroimage. 2020 Apr 1;209:116536 - PubMed
  32. J Prim Prev. 1996 Jun;16(4):343-56 - PubMed
  33. Am J Public Health. 2003 Sep;93(9):1576-82 - PubMed
  34. Front Endocrinol (Lausanne). 2014 May 13;5:73 - PubMed
  35. Hum Brain Mapp. 2018 May;39(5):1982-1994 - PubMed
  36. Curr Opin Behav Sci. 2016 Feb;7:76-81 - PubMed
  37. J Health Soc Behav. 1996 Dec;37(4):293-310 - PubMed
  38. Am J Psychiatry. 2016 Jun 1;173(6):625-34 - PubMed
  39. J Natl Cancer Inst. 2002 Jun 19;94(12):916-25 - PubMed
  40. Child Dev. 2008 Jan-Feb;79(1):156-69 - PubMed
  41. Am J Psychiatry. 2011 Nov;168(11):1210-20 - PubMed
  42. J Neurosci. 2006 Apr 19;26(16):4415-25 - PubMed
  43. Biol Psychiatry. 2000 Nov 15;48(10):976-80 - PubMed
  44. Neuropsychopharmacology. 2016 Feb;41(3):822-31 - PubMed
  45. Int J Environ Res Public Health. 2012 Jun;9(6):2204-25 - PubMed
  46. J Child Psychol Psychiatry. 2009 Oct;50(10):1309-17 - PubMed
  47. Child Psychiatry Hum Dev. 2016 Jun;47(3):440-58 - PubMed
  48. Soc Sci Med. 2011 Sep;73(5):737-43 - PubMed
  49. Sci Rep. 2017 Aug 16;7(1):8313 - PubMed
  50. Pediatrics. 2017 Jan;139(1): - PubMed
  51. Ann N Y Acad Sci. 1999;896:131-44 - PubMed
  52. Nat Rev Neurosci. 2010 Sep;11(9):651-9 - PubMed
  53. J Aging Health. 2010 Feb;22(1):27-47 - PubMed
  54. N Engl J Med. 2018 Jun 28;378(26):2456-2458 - PubMed
  55. Dev Psychopathol. 2017 Dec;29(5):1649-1662 - PubMed
  56. Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1312-9 - PubMed
  57. Rev Environ Health. 2011;26(3):141-7 - PubMed
  58. Psychiatry Res. 2013 Jul 30;213(1):24-30 - PubMed
  59. Ann Intern Med. 2014 Dec 2;161(11):765-74 - PubMed
  60. Science. 2012 Sep 21;337(6101):1505-10 - PubMed
  61. Dev Cogn Neurosci. 2020 Jun 30;45:100811 - PubMed
  62. Health Place. 2010 Sep;16(5):876-84 - PubMed
  63. Brain Connect. 2012;2(3):125-41 - PubMed
  64. Dev Sci. 2018 Sep;21(5):e12631 - PubMed
  65. Curr Top Behav Neurosci. 2018;38:117-136 - PubMed
  66. JAMA. 2005 Dec 14;294(22):2879-88 - PubMed
  67. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15638-43 - PubMed
  68. Aggress Behav. 2016 Sep;42(5):441-54 - PubMed
  69. Biol Psychiatry. 2020 Feb 15;87(4):350-358 - PubMed
  70. J Nerv Ment Dis. 2013 Dec;201(12):1007-20 - PubMed
  71. JAMA Netw Open. 2018 Nov 2;1(7):e184945 - PubMed
  72. Prim Care. 2017 Mar;44(1):155-170 - PubMed
  73. Biol Psychiatry. 2019 Jan 15;85(2):172-181 - PubMed
  74. J Trauma Stress. 2011 Dec;24(6):747-51 - PubMed
  75. Nat Med. 2020 Jan;26(1):91-97 - PubMed
  76. Eur J Neurosci. 2015 Feb;41(4):442-53 - PubMed
  77. Science. 1997 Aug 15;277(5328):918-24 - PubMed
  78. Dev Psychopathol. 2017 May;29(2):505-518 - PubMed
  79. Behav Neurosci. 2011 Feb;125(1):20-8 - PubMed
  80. Psychol Med. 2010 May;40(5):847-59 - PubMed
  81. Neuroimage. 2012 Sep;62(3):1575-81 - PubMed
  82. Arch Gen Psychiatry. 2009 Dec;66(12):1361-72 - PubMed
  83. PLoS One. 2012;7(9):e45419 - PubMed
  84. Ann Behav Med. 2004 Aug;28(1):20-8 - PubMed
  85. J Marriage Fam. 2010 Jun;72(3):685-704 - PubMed
  86. Brain Behav Immun. 2018 Oct;73:725-730 - PubMed
  87. Cereb Cortex. 2017 Jan 1;27(1):460-473 - PubMed
  88. JAMA Pediatr. 2013 Dec;167(12):1135-42 - PubMed
  89. Biol Psychiatry. 2009 Sep 1;66(5):407-14 - PubMed
  90. Soc Sci Med. 2013 Aug;90:24-31 - PubMed
  91. J Am Acad Child Adolesc Psychiatry. 2011 Aug;50(8):828-37.e3 - PubMed
  92. Neuroimage. 2011 Jun 1;56(3):881-9 - PubMed
  93. Neuropsychopharmacology. 2015 Jun;40(7):1717-25 - PubMed
  94. Am J Public Health. 2014 Sep;104(9):1734-41 - PubMed
  95. Eur J Public Health. 2012 Dec;22(6):760-5 - PubMed
  96. JAMA Netw Open. 2018 Jul 6;1(3):e180298 - PubMed
  97. Neuropsychopharmacology. 2014 Feb;39(3):545-55 - PubMed
  98. Psychol Bull. 2000 Mar;126(2):309-37 - PubMed
  99. JAMA Psychiatry. 2017 May 1;74(5):465-475 - PubMed
  100. Biol Psychiatry. 2019 Dec 15;86(12):921-929 - PubMed
  101. Arch Gen Psychiatry. 2005 May;62(5):554-63 - PubMed
  102. J Am Acad Child Adolesc Psychiatry. 2010 May;49(5):444-52 - PubMed
  103. Cereb Cortex. 2011 Jul;21(7):1667-73 - PubMed
  104. Am J Public Health. 2003 Jul;93(7):1137-43 - PubMed
  105. Perspect Psychol Sci. 2013 Nov;8(6):673-5 - PubMed
  106. Front Hum Neurosci. 2012 Oct 12;6:277 - PubMed
  107. Psychol Sci. 2005 Jul;16(7):560-5 - PubMed
  108. Biol Psychiatry. 2017 Oct 1;82(7):511-521 - PubMed
  109. J Neurosci. 2008 Apr 2;28(14):3586-94 - PubMed
  110. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12063-12068 - PubMed
  111. J Health Soc Behav. 2001 Jun;42(2):151-65 - PubMed
  112. Health Place. 2009 Dec;15(4):961-70 - PubMed
  113. JAMA Pediatr. 2017 Jan 1;171(1):53-60 - PubMed
  114. J Neurosci. 2013 Mar 6;33(10):4584-93 - PubMed
  115. Biol Psychiatry. 2015 Feb 1;77(3):276-284 - PubMed
  116. Soc Sci Med. 1998 Feb-Mar;46(4-5):611-23 - PubMed
  117. Exp Neurol. 2012 Jan;233(1):102-11 - PubMed
  118. J Psychosom Res. 2002 Oct;53(4):891-5 - PubMed
  119. Nat Rev Neurosci. 2018 Jul;19(7):428-438 - PubMed
  120. Annu Rev Public Health. 2006;27:103-24 - PubMed
  121. City Community. 2012 Dec 1;11(4):370-388 - PubMed
  122. Neuropsychopharmacology. 2014 Apr;39(5):1245-53 - PubMed
  123. J Health Soc Behav. 2003 Dec;44(4):552-71 - PubMed
  124. Curr Opin Behav Sci. 2017 Apr;14:133-139 - PubMed
  125. Soc Sci Med. 2002 Jul;55(1):125-39 - PubMed

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