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Niida Y, Masuda M, Adachi Y, et al. Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease. J Clin Biochem Nutr. 2020;67(2):179-187doi: 10.3164/jcbn.20-24.
Niida, Y., Masuda, M., Adachi, Y., Yoshizawa, A., Ohminami, H., Mori, Y., Ohnishi, K., Yamanaka-Okumura, H., Uchida, T., Nikawa, T., Yamamoto, H., Miyazaki, M., & Taketani, Y. (2020). Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease. Journal of clinical biochemistry and nutrition, 67(2), 179-187. https://doi.org/10.3164/jcbn.20-24
Niida, Yuki, et al. "Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease." Journal of clinical biochemistry and nutrition vol. 67,2 (2020): 179-187. doi: https://doi.org/10.3164/jcbn.20-24
Niida Y, Masuda M, Adachi Y, Yoshizawa A, Ohminami H, Mori Y, Ohnishi K, Yamanaka-Okumura H, Uchida T, Nikawa T, Yamamoto H, Miyazaki M, Taketani Y. Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease. J Clin Biochem Nutr. 2020 Sep;67(2):179-187. doi: 10.3164/jcbn.20-24. Epub 2020 Jun 09. PMID: 33041516; PMCID: PMC7533850.
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J Clin Biochem Nutr. 2020 Sep;67(2):179-187. doi: 10.3164/jcbn.20-24. Epub 2020 Jun 09.

Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease.

Journal of clinical biochemistry and nutrition

Yuki Niida, Masashi Masuda, Yuichiro Adachi, Aika Yoshizawa, Hirokazu Ohminami, Yuki Mori, Kohta Ohnishi, Hisami Yamanaka-Okumura, Takayuki Uchida, Takeshi Nikawa, Hironori Yamamoto, Makoto Miyazaki, Yutaka Taketani

Affiliations

  1. Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
  2. Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
  3. Department of Health and Nutrition, Faculty of Human Life, Jin-ai University, 3-1-1 Ohde-cho, Fukui 915-8586, Japan.
  4. Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
  5. Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA.

PMID: 33041516 PMCID: PMC7533850 DOI: 10.3164/jcbn.20-24

Abstract

Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.

Copyright © 2020 JCBN.

Keywords: chronic kidney disease; endoplasmic reticulum stress; saturated fatty acid; skeletal muscle atrophy; stearoyl-CoA desaturase

Conflict of interest statement

No potential conflicts of interest were disclosed.

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