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Mejia Buritica L, Santiago-Pacheco V, Perilla O, et al. Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome With IgG Kappa/IgG Lambda Biclonal Gammopathy: A Rare Presentation of a Rare Disease. Cureus. 2020;12(9):e10232doi: 10.7759/cureus.10232.
Mejia Buritica, L., Santiago-Pacheco, V., Perilla, O., & Quintero, D. (2020). Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome With IgG Kappa/IgG Lambda Biclonal Gammopathy: A Rare Presentation of a Rare Disease. Cureus, 12(9), e10232. https://doi.org/10.7759/cureus.10232
Mejia Buritica, Leonardo, et al. "Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome With IgG Kappa/IgG Lambda Biclonal Gammopathy: A Rare Presentation of a Rare Disease." Cureus vol. 12,9 (2020): e10232. doi: https://doi.org/10.7759/cureus.10232
Mejia Buritica L, Santiago-Pacheco V, Perilla O, Quintero D. Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome With IgG Kappa/IgG Lambda Biclonal Gammopathy: A Rare Presentation of a Rare Disease. Cureus. 2020 Sep 03;12(9):e10232. doi: 10.7759/cureus.10232. PMID: 33042673; PMCID: PMC7535869.
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Cureus. 2020 Sep 03;12(9):e10232. doi: 10.7759/cureus.10232.

Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome With IgG Kappa/IgG Lambda Biclonal Gammopathy: A Rare Presentation of a Rare Disease.

Cureus

Leonardo Mejia Buritica, Vanessa Santiago-Pacheco, Oliver Perilla, Dayana Quintero

Affiliations

  1. Department of Hematology, Universidad de Antioquia, Medellín, COL.
  2. Department of Hematopathology, Universidad de Antioquia, Medellín, COL.
  3. Department of Internal Medicine, Universidad Pontificia Bolivariana, Medellín, COL.

PMID: 33042673 PMCID: PMC7535869 DOI: 10.7759/cureus.10232

Abstract

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a low prevalence multisystemic paraneoplastic disease. The name is an acronym composed by its most relevant clinical manifestations, which are polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. More than 95% of the POEMS syndrome cases are monoclonal for lambda light chains; however, few cases have been reported in the literature with a biclonal component. In this paper, we report a rare case of a patient who has POEMS syndrome with biclonal gammopathy. To the best of our knowledge, this is the first reported case in the literature of POEMS syndrome with expression of IgG kappa/IgG lambda biclonal gammopathy.

Copyright © 2020, Mejia Buritica et al.

Keywords: biclonal gammopathy; castleman disease; poems syndrome

Conflict of interest statement

The authors have declared that no competing interests exist.

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