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Janssen R, Serré J, Piscaer I, et al. . ERJ Open Res. 2020;6(4)doi: 10.1183/23120541.00128-2019.
Janssen, R., Serré, J., Piscaer, I., Zaal, R., van Daal, H., Mathyssen, C., Zanen, P., van den Ouweland, J. M. W., & Janssens, W. (2020). . ERJ open research, 6(4), . https://doi.org/10.1183/23120541.00128-2019
Janssen, Rob, et al. "." ERJ open research vol. 6,4 (2020). doi: https://doi.org/10.1183/23120541.00128-2019
Janssen R, Serré J, Piscaer I, Zaal R, van Daal H, Mathyssen C, Zanen P, van den Ouweland JMW, Janssens W. . ERJ Open Res. 2020 Oct 05;6(4). doi: 10.1183/23120541.00128-2019. eCollection 2020 Oct. PMID: 33043047; PMCID: PMC7533306.
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ERJ Open Res. 2020 Oct 05;6(4). doi: 10.1183/23120541.00128-2019. eCollection 2020 Oct.

[No title available]

ERJ open research

Rob Janssen, Jef Serré, Ianthe Piscaer, Ruben Zaal, Henny van Daal, Carolien Mathyssen, Pieter Zanen, Jody M W van den Ouweland, Wim Janssens

Affiliations

  1. Dept of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
  2. Laboratory of Respiratory Diseases, Catholic University Leuven, Leuven, Belgium.
  3. Both authors contributed equally to the study.
  4. Dept of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
  5. Ziekenhuisgroep Twente, Hengelo, The Netherlands.
  6. Clinical Chemistry, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
  7. Dept of Respiratory Medicine, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands.

PMID: 33043047 PMCID: PMC7533306 DOI: 10.1183/23120541.00128-2019

Abstract

BACKGROUND: Vitamin D supplementation lowers exacerbation frequency in severe vitamin D-deficient patients with COPD. Data regarding the effect of vitamin D on elastin degradation are lacking. Based on the vitamin's anti-inflammatory properties, we hypothesised that vitamin D supplementation reduces elastin degradation, particularly in vitamin D-deficient COPD patients. We assessed the effect of vitamin D status and supplementation on elastin degradation by measuring plasma desmosine, a biomarker of elastin degradation.

METHODS: Desmosine was measured every 4 months in plasma of 142 vitamin D-naïve COPD patients from the Leuven vitamin D intervention trial (100 000 IU vitamin D3 supplementation every 4 weeks for 1 year).

RESULTS: No significant association was found between baseline 25-hydroxyvitamin D (25(OH)D) and desmosine levels. No significant difference in desmosine change over time was found between the placebo and intervention group during the course of the trial. In the intervention arm, an unexpected inverse association was found between desmosine change and baseline 25(OH)D levels (p=0.005).

CONCLUSIONS: Vitamin D supplementation did not have a significant overall effect on elastin degradation compared to placebo. Contrary to our hypothesis, the intervention decelerated elastin degradation in vitamin D-sufficient COPD patients and not in vitamin D-deficient subjects.

Copyright ©ERS 2020.

Conflict of interest statement

Conflict of interest: R. Janssen has a patent, “Method and compositions to facilitate regeneration and repair of elastin fibers in lungs of patients with COPD” pending and is one of the owners of Desm

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