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Kim EJ, Kwon YJ, Lee HY, et al. The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder. Psychiatry Investig. 2020;17(10):996-1005doi: 10.30773/pi.2020.0074.
Kim, E. J., Kwon, Y. J., Lee, H. Y., Yoon, H. J., Kim, J. S., & Shim, S. H. (2020). The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder. Psychiatry investigation, 17(10), 996-1005. https://doi.org/10.30773/pi.2020.0074
Kim, Eun Jee, et al. "The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder." Psychiatry investigation vol. 17,10 (2020): 996-1005. doi: https://doi.org/10.30773/pi.2020.0074
Kim EJ, Kwon YJ, Lee HY, Yoon HJ, Kim JS, Shim SH. The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder. Psychiatry Investig. 2020 Oct;17(10):996-1005. doi: 10.30773/pi.2020.0074. Epub 2020 Oct 13. PMID: 33045796; PMCID: PMC7596285.
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Psychiatry Investig. 2020 Oct;17(10):996-1005. doi: 10.30773/pi.2020.0074. Epub 2020 Oct 13.

The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder.

Psychiatry investigation

Eun Jee Kim, Young Joon Kwon, Hwa-Young Lee, Hee-Jung Yoon, Ji Sun Kim, Se-Hoon Shim

Affiliations

  1. Department of Psychiatry, College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
  2. The Korean Society of Infectious Diseases, Seoul, Republic of Korea.

PMID: 33045796 PMCID: PMC7596285 DOI: 10.30773/pi.2020.0074

Abstract

OBJECTIVE: Attention-deficit and poor impulse control have frequently been observed in major depressive disorder (MDD) and attention-deficit and hyperactivity disorder (ADHD). Altered event-related potential (ERP) performance, such as GoNogo tasks, has been regarded as a neurocognitive process associated with attention and behavioral inhibition. The aim of this study was to investigate the association between Nogo ERP and adult ADHD in MDD.

METHODS: A total of 64 participants with MDD (32 comorbid with ADHD) and 32 healthy controls aged 19-45 years were recruited; they performed GoNogo paradigms during electroencephalogram measurement. Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and the Adult ADHD Self-Report Scale (ASRS) were evaluated. Clinical measures and GoNogo ERP were compared between three groups: depression with ADHD, depression without ADHD, and healthy controls.

RESULTS: MDD subjects with ADHD showed significantly decreased Nogo P3 amplitude at frontal electrode, compared with those without ADHD and healthy controls. MDD subjects with ADHD showed significantly longer Nogo N2 latency at frontal and frontocentral electrodes, compared with those without ADHD and healthy controls. In MDD subjects with ADHD, the Nogo P3 amplitude at the frontal electrode was negatively correlated with the ASRS score and inattention. The Nogo N2 latency at the frontal electrode was positively correlated with false alarm rate.

CONCLUSION: The decreased Nogo P3 amplitude in the frontal area might be a potential biological marker for inattention in depressed patients with ADHD.

Keywords: ADHD; Adult; Depression; Event related potential; GoNogo

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