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KM Kirschner, K Baltensperger - Molecular cancer research, 2003 - AACR

… : Current address of Dr. Karin M. Kirschner is at Johannes-Müller Institut fu̇r Physiologie, Charité-Universitätsmedizin Berlin, Campus Charité-Mitte, Tucholskystrasse ….

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GSID: 1s73hdO2Rq8J

Excerpt

Chronic myeloid leukemia is characterized by the Philadelphia chromosome translocation that causes expression of Bcr-Abl, a deregulated tyrosine kinase. Imatinib mesylate (STI571, Gleevec), a therapeutically used inhibitor of Bcr-Abl, causes apoptosis of Bcr-Abl-positive cells…

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