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K Kitani, C Minami, T Yamamoto… - Annals of the New …, 2002 - Wiley Online Library

Pharmacological Interventions in Aging and Age‐associated Disorders: Potentials of Propargylamines for Human Use.

Stem education interventions

[No authors listed]

GSID: 1Ey0q7sFmnUJ

Excerpt

Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species. Pretreatment with the drug for several weeks increases activities of superoxide dismutase (SOD) and catalase (CAT) in selective brain regions. An up‐regulation of antioxidant enzyme activities can also be induced in organs such as the heart, kidney, spleen, and adrenal gland, and all are accompanied by an increase in mRNA levels for SODs in these organs. The effect of …

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