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Conrado, D. J., Gonzalez, D., & Derendorf, H. (2010). Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke. Annals of the New York Academy of Sciences, 1207(1), 134-142.
Conrado, Daniela J., Daniel Gonzalez, and Hartmut Derendorf. "Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke." Annals of the New York Academy of Sciences 1207.1 (2010): 134-142.
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DJ Conrado, D Gonzalez… - Annals of the New York …, 2010 - Wiley Online Library

Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke.

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Conrado, Gonzalez

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Absorption is a critical component of the pharmacokinetics for solid dosage forms administered orally. Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug‐specific properties, formulation issues, and (patho) physiological changes in the gastrointestinal tract must be considered. First‐pass metabolism in the gut and/or liver can dictate the extent to which a drug reaches the systemic circulation. Drug‐metabolizing enzymes in the gut and liver are …

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