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T Miyata, M Yamamoto, Y Izuhara - Annals of the New York …, 2005 - Wiley Online Library

From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy.

Stem education interventions

[No authors listed]

GSID: 87c1fQfbhuYJ

Excerpt

Proteins are particularly attractive targets for product analysis, which is used to understand pathology. Protein modifications, such as advanced glycation end products (AGEs), serve as footprints of biochemical processes and also help in the search for novel agents that efficiently inhibit protein damage. Interestingly, several medical agents that are used clinically interfere with oxidative protein damage through different mechanisms characteristic of their chemical structures. We recently found that angiotensin II receptor blockers (ARBs) …

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