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Kastelein, J. J., van Leuven, S. I., Burgess, L., Evans, G. W., Kuivenhoven, J. A., Barter, P. J., ... & Bots, M. L. (2007). Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. New England Journal of Medicine, 356(16), 1620-1630.
Kastelein, John JP, et al. "Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia." New England Journal of Medicine 356.16 (2007): 1620-1630.
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JJP Kastelein, SI van Leuven, L Burgess… - … England Journal of …, 2007 - Mass Medical Soc

Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia.

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Background Torcetrapib, an inhibitor of cholesteryl ester transfer protein, may reduce atherosclerotic vascular disease by increasing levels of high-density lipoprotein (HDL) cholesterol. Methods A total of 850 patients with heterozygous familial hypercholesterolemia underwent B-mode ultrasonography at baseline and at follow-up to measure changes in carotid intima–media thickness. The patients completed an atorvastatin run-in period and were subsequently randomly assigned to receive either atorvastatin monotherapy or …

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