Extending the application of biocatalysis to meet the challenges of drug development

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PN Devine, RM Howard, R Kumar… - Nature Reviews …, 2018 - nature.com

Extending the application of biocatalysis to meet the challenges of drug development.

Build and Broaden 3.0 AND Program Evaluation

Kumar

GSID: MtNdMtCXuGYJ

Excerpt

The pharmaceutical industry, driven by an increasing need to deliver new and more effective medicines to patients, is increasingly turning to the use of engineered biocatalysts for both lead generation of active compounds and the sustainable manufacture of active pharmaceutical ingredients. Advances in enzyme discovery, high-throughput screening and protein engineering have substantially expanded the available biocatalysts, and consequently, many more synthetic transformations are now possible. Enzymes can be fine …

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Extending the application of biocatalysis to meet the challenges of drug development.

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