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JD Salvi, JY Lim, HJ Donahue - Journal of biomechanics, 2010 - Elsevier

Increased mechanosensitivity of cells cultured on nanotopographies.

EPSCoR Research Infrastructure Improvement Program AND Program Evaluation

Donahue, Lim, Salvi

GSID: DcVVmoHZxLoJ

Excerpt

Enhancing cellular mechanosensitivity is recognized as a novel tool for successful musculoskeletal tissue engineering. We examined the hypothesis that mechanosensitivity of human mesenchymal stem cells (hMSCs) is enhanced on nanotopographic substrates relative to flat surfaces. hMSCs were cultured on polymer-demixed, randomly distributed nanoisland surfaces with varying island heights and changes in intracellular calcium concentration,[Ca 2+] i, in response to fluid flow induced shear stress were quantifide. Stem …

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