HA Bullen, R Hemmer, A Haskamp, C Cason… - Journal of Biomaterials …, 2011 - scirp.org

Evaluation of biotinylated PAMAM dendrimer toxicity in models of the blood brain barrier: a biophysical and cellular approach.

EPSCoR Research Infrastructure Improvement Program AND Program Evaluation

[No authors listed]

GSID: og9nyXeY4jEJ

Excerpt

The interaction of biotinylated G4 poly (amidoamine)(PAMAM) dendrimer conjugates and G4 PAMAM dendrimers with in vitro models of the blood brain barrier (BBB) was evaluated using Langmuir Blodgett monolayer techniques, atomic force microscopy (AFM) and lactate dehydrogenase measures of cell membrane toxicity. Results indicate that both G4 and G4 biotinylated PAMAM dendrimers disrupt the composition of the liquid condensed (LC) and liquid expanded (LE) phases of the 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) …

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