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Hemmer, R., Hall, A., Spaulding, R., Rossow, B., Hester, M., Caroway, M., ... & Haik, K. L. (2013). Analysis of biotinylated generation 4 poly (amidoamine)(PAMAM) dendrimer distribution in the rat brain and toxicity in a cellular model of the blood-brain barrier. Molecules, 18(9), 11537-11552.
Hemmer, Ruth, et al. "Analysis of biotinylated generation 4 poly (amidoamine)(PAMAM) dendrimer distribution in the rat brain and toxicity in a cellular model of the blood-brain barrier." Molecules 18.9 (2013): 11537-11552.
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R Hemmer, A Hall, R Spaulding, B Rossow, M Hester… - Molecules, 2013 - mdpi.com

Analysis of biotinylated generation 4 poly (amidoamine)(PAMAM) dendrimer distribution in the rat brain and toxicity in a cellular model of the blood-brain barrier.

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Excerpt

Dendrimers are highly customizable nanopolymers with qualities that make them ideal for drug delivery. The high binding affinity of biotin/avidin provides a useful approach to fluorescently label synthesized dendrimer-conjugates in cells and tissues. In addition, biotin may facilitate delivery of dendrimers through the blood-brain barrier (BBB) via carrier-mediated endocytosis. The purpose of this research was to:(1) measure toxicity using lactate dehydrogenase (LDH) assays of generation (G) 4 biotinylated and non-biotinylated poly …

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