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Abdulhasan, A. F., Abeer, M. I. U., & Narayanaswami, V. (2020). Structural and Functional Analysis of Apolipoprotein E3 Modification by a Lipid Peroxidation Product, 4‐Hydroxynonenal. The FASEB Journal, 34(S1), 1-1.
Abdulhasan, Abbas F., Muhammad Imam Uddin Abeer, and Vasanthy Narayanaswami. "Structural and Functional Analysis of Apolipoprotein E3 Modification by a Lipid Peroxidation Product, 4‐Hydroxynonenal." The FASEB Journal 34.S1 (2020): 1-1.
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AF Abdulhasan, MIU Abeer… - The FASEB …, 2020 - Wiley Online Library

Structural and Functional Analysis of Apolipoprotein E3 Modification by a Lipid Peroxidation Product, 4‐Hydroxynonenal.

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Abdulhasan

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Background Post mortem tissues from brains of Alzheimer's disease (AD) patients show higher levels of 4‐hydroxynonenal (4‐HNE)‐modified proteins, with 4‐HNE arising as a result of oxidative stress and lipid peroxidation. The overall goal of our study is to understand the effect of 4‐HNE modification on the structure and function of apolipoprotein E3 (apoE3) and apoE4, which are 34 kDa exchangeable apolipoprotein isoforms that play a critical role in brain cholesterol homeostasis. Individuals carrying the APOE ɛ4 allele are at …

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