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Williamson, B., Wilk, A., Guerrero, K. D., Mikulski, T. D., Elias, T. N., Sawh, I., ... & Healey, K. R. (2022). Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility. Antimicrobial agents and chemotherapy, 66(1), e01624-21.
Williamson, Benjamin, et al. "Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility." Antimicrobial agents and chemotherapy 66.1 (2022): e01624-21.
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B Williamson, A Wilk, KD Guerrero… - Antimicrobial agents …, 2022 - Am Soc Microbiol

Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility.

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ABSTRACT ERG11 sequencing of 28 Candida auris clade III isolates revealed the presence of concomitant V125A and F126L substitutions. Heterologous expression of Erg11-V125A/F126L in Saccharomyces cerevisiae led to reduced fluconazole and voriconazole susceptibilities. Generation of single substitution gene variants through site-directed mutagenesis uncovered that F126L primarily contributes to the elevated triazole MICs. A similar yet diminished pattern of reduced susceptibility was observed with the long-tailed …

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