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Valle-Mojica, D., Lisa, M., Cordero-Hernández, J. M., González-Medina, G., Ramos-Vélez, I., Berríos-Cartagena, N., ... & Ortíz, J. G. (2011). Aqueous and ethanolic Valeriana officinalis extracts change the binding of ligands to glutamate receptors. Evidence-Based Complementary and Alternative Medicine, 2011.
Valle-Mojica, Del, et al. "Aqueous and ethanolic Valeriana officinalis extracts change the binding of ligands to glutamate receptors." Evidence-Based Complementary and Alternative Medicine 2011 (2011).
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D Valle-Mojica, M Lisa… - Evidence-Based …, 2011 - hindawi.com

Aqueous and ethanolic Valeriana officinalis extracts change the binding of ligands to glutamate receptors.

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The effects of two valerian extracts (aqueous and hydroalcoholic) were investigated through [3 H] Glutamate ([3 H] Glu) and [3 H] Fluorowillardine ([3 H] FW) receptor binding assays using rat synaptic membranes in presence of different receptor ligands. In addition, the extract stability was monitored spectrophotometrically. Both extracts demonstrated interaction with ionotropic glutamate receptors (iGluRs). However, the extracts displayed considerable differences in receptor selectivity. The hydroalcoholic extract selectively …

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