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Moseson, D. E., Jordan, M. A., Shah, D. D., Corum, I. D., Alvarenga Jr, B. R., & Taylor, L. S. (2020). Application and limitations of thermogravimetric analysis to delineate the hot melt extrusion chemical stability processing window. International Journal of Pharmaceutics, 590, 119916.
Moseson, Dana E., et al. "Application and limitations of thermogravimetric analysis to delineate the hot melt extrusion chemical stability processing window." International Journal of Pharmaceutics 590 (2020): 119916.
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DE Moseson, MA Jordan, DD Shah, ID Corum… - International Journal of …, 2020 - Elsevier

Application and limitations of thermogravimetric analysis to delineate the hot melt extrusion chemical stability processing window.

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Thermogravimetric analysis (TGA) is frequently used to define the threshold of acceptable processing temperatures for hot melt extrusion. Herein, evaluation of chemical stability of amorphous drug and polymer systems was assessed by a critical evaluation of TGA nonisothermal and isothermal methods. Nonisothermal analysis of three crystalline APIs of high glass-forming ability (posaconazole, indomethacin, and bicalutamide), as well as six common polymers, identified a degradation onset temperature that ranged from 52 to 170° …

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