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Okamoto M, Sakai T, Hayashi K. Switching mechanism of a cyclic enzyme system: role as a "chemical diode". Biosystems. 1987;21(1):1-11doi: 10.1016/0303-2647(87)90002-5.
Okamoto, M., Sakai, T., & Hayashi, K. (1987). Switching mechanism of a cyclic enzyme system: role as a "chemical diode". Bio Systems, 21(1), 1-11. https://doi.org/10.1016/0303-2647(87)90002-5
Okamoto, M, et al. "Switching mechanism of a cyclic enzyme system: role as a "chemical diode"." Bio Systems vol. 21,1 (1987): 1-11. doi: https://doi.org/10.1016/0303-2647(87)90002-5
Okamoto M, Sakai T, Hayashi K. Switching mechanism of a cyclic enzyme system: role as a "chemical diode". Biosystems. 1987;21(1):1-11. doi: 10.1016/0303-2647(87)90002-5. PMID: 3689885.
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Elsevier Science

Biosystems. 1987;21(1):1-11. doi: 10.1016/0303-2647(87)90002-5.

Switching mechanism of a cyclic enzyme system: role as a "chemical diode".

Bio Systems

M Okamoto, T Sakai, K Hayashi

Affiliations

  1. Department of Agricultural Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

PMID: 3689885 DOI: 10.1016/0303-2647(87)90002-5

Abstract

We previously showed with computer simulations that cyclic enzyme systems play a role in metabolic switching events. In the present study, the detailed switching mechanism was investigated by clarifying the relationship between the switching mode and the phase-difference of two sinusoidal inputs to the cyclic enzyme system. The switching time could be predicted theoretically. Half-wave and full-wave rectifications were observed when the phase-difference of two sinusoidal inputs is equal to pi. This result indicates the possibility that this cyclic enzyme system is available for use as a switching circuit (biochip) in a bio-computer.

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