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Su CH, Greene RC. Regulation of methionine biosynthesis in Escherichia coli: mapping of the metJ locus and properties of a metJ plus-metJ minus diploid. Proc Natl Acad Sci U S A. 1971;68(2):367-71doi: 10.1073/pnas.68.2.367.
Su, C. H., & Greene, R. C. (1971). Regulation of methionine biosynthesis in Escherichia coli: mapping of the metJ locus and properties of a metJ plus-metJ minus diploid. Proceedings of the National Academy of Sciences of the United States of America, 68(2), 367-71. https://doi.org/10.1073/pnas.68.2.367
Su, C H, and Greene, R C. "Regulation of methionine biosynthesis in Escherichia coli: mapping of the metJ locus and properties of a metJ plus-metJ minus diploid." Proceedings of the National Academy of Sciences of the United States of America vol. 68,2 (1971): 367-71. doi: https://doi.org/10.1073/pnas.68.2.367
Su CH, Greene RC. Regulation of methionine biosynthesis in Escherichia coli: mapping of the metJ locus and properties of a metJ plus-metJ minus diploid. Proc Natl Acad Sci U S A. 1971 Feb;68(2):367-71. doi: 10.1073/pnas.68.2.367. PMID: 5277087; PMCID: PMC388939.
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Proc Natl Acad Sci U S A. 1971 Feb;68(2):367-71. doi: 10.1073/pnas.68.2.367.

Regulation of methionine biosynthesis in Escherichia coli: mapping of the metJ locus and properties of a metJ plus-metJ minus diploid.

Proceedings of the National Academy of Sciences of the United States of America

C H Su, R C Greene

PMID: 5277087 PMCID: PMC388939 DOI: 10.1073/pnas.68.2.367
Free PMC Article

Abstract

MetJ(-) mutants of Escherichia coli have elevated nonrepressible levels of the enzymes of methionine biosynthesis and S-adenosylmethionine synthetase (ATP:L-methionine S-adenosyltransferase, EC 2.5.1.6). In E. coli, as in Salmonella typhimurium, the metJ locus is close to metB (95% cotransduction of metB and metJ markers), but in E. coli the order is reversed, with metJ mapping clockwise to metB. A stable merodiploid, heterozygous for metJ, is subject to repression by methionine. Thus, metJ functions via a diffusible product. MetJ could either be a regulatory locus or could code for an enzyme required for the synthesis of a methionine metabolite that functions in the control system.

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