Magn Reson Med. 1994 Mar;31(3):320-2. doi: 10.1002/mrm.1910310312.
Magnetic resonance in medicine
T A Spraggins
PMID: 8057804 DOI: 10.1002/mrm.1910310312
Keyhole imaging is a scheme introduced to improve temporal resolution in dynamic contrast-enhanced MRI by a factor of four or more. A "full" acquisition before contrast administration is followed by truncated acquisitions sensitive primarily to changes in image contrast. Simulations of the point-spread functions that obtain, and their effect on contrast and spatial resolution, reveal significant degradation only for the smallest objects. Our simulations also address the feasibility of three-dimensional keyhold imaging, and demonstrate a potential 16-fold increase in temporal resolution. This suggests roles for keyhole imaging in conventional (nondynamic) precontrast and postcontrast studies and other applications.