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Kim YP, Takamatsu S, Hayashi M, et al. Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711. J Antibiot (Tokyo). 1997;50(3):189-93
Kim, Y. P., Takamatsu, S., Hayashi, M., Komiyama, K., & Omura, S. (1997). Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711. The Journal of antibiotics, 50(3), 189-93.
Kim, et al. "Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711." The Journal of antibiotics vol. 50,3 (1997): 189-93.
Kim YP, Takamatsu S, Hayashi M, Komiyama K, Omura S. Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711. J Antibiot (Tokyo). 1997 Mar;50(3):189-93. PMID: 9439688.
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J Antibiot (Tokyo). 1997 Mar;50(3):189-93.

Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711.

The Journal of antibiotics

Kim, Takamatsu, Hayashi, Komiyama, Omura

Affiliations

  1. Kitasato Institute, Tokyo, Japan.

PMID: 9439688

Abstract

Two new alkaloids with the beta-carboline skeleton, pyridindolols K1 (C18H18N2O5) and K2 (C16H16N2O4), were isolated from the culture broth of Streptomyces sp. K93-0711. The structure of pyridindolols were established by spectroscopic investigations and chemical transformations. Pyridindolol K2 inhibited the adhesion of HL-60 cells to LPS-activated HUVEC monolayer (IC50 = 75 micrograms/ml).

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