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Cai SX, Ikeda M, Inoue O, et al. Urinary Phenylglyoxylic Acid Excretion after Exposure to Ethylbenzene among Solvent-exposed Chinese Workers. Int J Occup Environ Health. 1995;1(1):1-8doi: 10.1179/oeh.1995.1.1.1.
Cai, S. X., Ikeda, M., Inoue, O., Jin, C., Kudo, S., Liu, S. J., Nakatsuka, H., Seiji, K., & Watanabe, T. (1995). Urinary Phenylglyoxylic Acid Excretion after Exposure to Ethylbenzene among Solvent-exposed Chinese Workers. International journal of occupational and environmental health, 1(1), 1-8. https://doi.org/10.1179/oeh.1995.1.1.1
Cai, et al. "Urinary Phenylglyoxylic Acid Excretion after Exposure to Ethylbenzene among Solvent-exposed Chinese Workers." International journal of occupational and environmental health vol. 1,1 (1995): 1-8. doi: https://doi.org/10.1179/oeh.1995.1.1.1
Cai SX, Ikeda M, Inoue O, Jin C, Kudo S, Liu SJ, Nakatsuka H, Seiji K, Watanabe T. Urinary Phenylglyoxylic Acid Excretion after Exposure to Ethylbenzene among Solvent-exposed Chinese Workers. Int J Occup Environ Health. 1995 Jan;1(1):1-8. doi: 10.1179/oeh.1995.1.1.1. PMID: 9990150.
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Int J Occup Environ Health. 1995 Jan;1(1):1-8. doi: 10.1179/oeh.1995.1.1.1.

Urinary Phenylglyoxylic Acid Excretion after Exposure to Ethylbenzene among Solvent-exposed Chinese Workers.

International journal of occupational and environmental health

Cai, Ikeda, Inoue, Jin, Kudo, Liu, Nakatsuka, Seiji, Watanabe

Affiliations

  1. Department of Public Health, Kyoto University Faculty of Medicine, Kyoto 606-01, Japan.

PMID: 9990150 DOI: 10.1179/oeh.1995.1.1.1

Abstract

Factory surveys were conducted in the second half of work weeks on 360 solvent workers (202 men and 158 women) and 281 controls in China. Monitoring personal exposures showed that ethylbenzene exposure was low (geometric mean 1.8 ppm) and was accompanied by coexposure to toluene (1.5 ppm) and three xylene isomers (6.7 ppm). Urine samples collected at the end of the eight-hour shift were analyzed for phenylglyoxylic and mandelic acids by high-pressure liquid chromatography at 257 nm. Despite the low level of the exposures, a significant correlation was observed between ethylbenzene exposure and urinary phenylglyoxylic acid, with high (0.6-0.7) correlation coefficients, suggesting that urinary phenylglyoxylic acid is a good marker of occupational exposure to ethylbenzene. Mandelic acid also correlated with ethylbenzene exposure, but with much smaller coefficients (0.2), possibly because the method employed was more sensitive to phenylglyoxylic acid than to mandelic acid.

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