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Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells.

Cell death discovery

Gailhouste L, Sudoh M, Qin XY, Watashi K, Wakita T, Ochiya T, Matsuura T, Kojima S, Furutani Y.
PMID: 34078875
Cell Death Discov. 2021 Jun 02;7(1):130. doi: 10.1038/s41420-021-00515-y.

Chronic hepatitis B virus (HBV) infections remain a health burden affecting ~250 million people worldwide. Thus far, available interferon-alpha (IFNα)-based therapies have shown unsatisfactory cure rates, and alternative therapeutic molecules are still required. However, their development has been hampered...

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Gailhouste L, Sudoh M, Qin XY, et al. Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells. Cell Death Discov. 2021;7(1):130doi: 10.1038/s41420-021-00515-y.
Gailhouste, L., Sudoh, M., Qin, X. Y., Watashi, K., Wakita, T., Ochiya, T., Matsuura, T., Kojima, S., & Furutani, Y. (2021). Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells. Cell death discovery, 7(1), 130. https://doi.org/10.1038/s41420-021-00515-y
Gailhouste, Luc, et al. "Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells." Cell death discovery vol. 7,1 (2021): 130. doi: https://doi.org/10.1038/s41420-021-00515-y
Gailhouste L, Sudoh M, Qin XY, Watashi K, Wakita T, Ochiya T, Matsuura T, Kojima S, Furutani Y. Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells. Cell Death Discov. 2021 Jun 02;7(1):130. doi: 10.1038/s41420-021-00515-y. PMID: 34078875; PMCID: PMC8170866.
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OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s.

Allergy, asthma & immunology research

Chang Y, Kang JS, Jung K, Chung DH, Ha SJ, Kim YJ, Kim HY.
PMID: 34983110
Allergy Asthma Immunol Res. 2022 Jan;14(1):99-116. doi: 10.4168/aair.2022.14.1.99.

PURPOSE: Three observations drove this study. First, 2'-5'-oligoadenylate synthetase-like protein (OASL) is a negative regulator of type I interferon (IFN). Second, type I IFN plays a central role during virus infections and the pathogenesis of various diseases, including asthma....

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Chang Y, Kang JS, Jung K, et al. OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s. Allergy Asthma Immunol Res. 2022;14(1):99-116doi: 10.4168/aair.2022.14.1.99.
Chang, Y., Kang, J. S., Jung, K., Chung, D. H., Ha, S. J., Kim, Y. J., & Kim, H. Y. (2022). OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s. Allergy, asthma & immunology research, 14(1), 99-116. https://doi.org/10.4168/aair.2022.14.1.99
Chang, Yuna, et al. "OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s." Allergy, asthma & immunology research vol. 14,1 (2022): 99-116. doi: https://doi.org/10.4168/aair.2022.14.1.99
Chang Y, Kang JS, Jung K, Chung DH, Ha SJ, Kim YJ, Kim HY. OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s. Allergy Asthma Immunol Res. 2022 Jan;14(1):99-116. doi: 10.4168/aair.2022.14.1.99. PMID: 34983110; PMCID: PMC8724833.
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Improved lentiviral vector titers from a multi-gene knockout packaging line.

Molecular therapy oncolytics

Han J, Tam K, Tam C, Hollis RP, Kohn DB.
PMID: 34938858
Mol Ther Oncolytics. 2021 Nov 20;23:582-592. doi: 10.1016/j.omto.2021.11.012. eCollection 2021 Dec 17.

Lentiviral vectors (LVs) are robust delivery vehicles for gene therapy as they can efficiently integrate transgenes into host cell genomes. However, LVs with lengthy or complex expression cassettes typically are produced at low titers and have reduced gene transfer...

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Han J, Tam K, Tam C, et al. Improved lentiviral vector titers from a multi-gene knockout packaging line. Mol Ther Oncolytics. 2021;23:582-592doi: 10.1016/j.omto.2021.11.012.
Han, J., Tam, K., Tam, C., Hollis, R. P., & Kohn, D. B. (2021). Improved lentiviral vector titers from a multi-gene knockout packaging line. Molecular therapy oncolytics, 23582-592. https://doi.org/10.1016/j.omto.2021.11.012
Han, Jiaying, et al. "Improved lentiviral vector titers from a multi-gene knockout packaging line." Molecular therapy oncolytics vol. 23 (2021): 582-592. doi: https://doi.org/10.1016/j.omto.2021.11.012
Han J, Tam K, Tam C, Hollis RP, Kohn DB. Improved lentiviral vector titers from a multi-gene knockout packaging line. Mol Ther Oncolytics. 2021 Nov 20;23:582-592. doi: 10.1016/j.omto.2021.11.012. eCollection 2021 Dec 17. PMID: 34938858; PMCID: PMC8660686.
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Establishment of a nonradioactive assay for 2'-5' oligoadenylate synthetase and its application in chronic hepatitis C patients receiving interferon-alpha.

World journal of gastroenterology

Tong WB, Zhang CY, Feng BF, Tao QM.
PMID: 11819237
World J Gastroenterol. 1998 Feb;4(1):70-73. doi: 10.3748/wjg.v4.i1.70.

AIM:To establish a nonradioactive assay for 2'-5' oligoadenylate synthetase (2-5 AS) and to measure the 2-5AS in peripheral blood mononuclear cell (PBMC) extracts of patients with chronic hepatitis C before IFN-alphainjection, 24 hours and one month after the first...

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Tong WB, Zhang CY, Feng BF, et al. Establishment of a nonradioactive assay for 2'-5' oligoadenylate synthetase and its application in chronic hepatitis C patients receiving interferon-alpha. World J Gastroenterol. 1998;4(1):70-73doi: 10.3748/wjg.v4.i1.70.
Tong, W. B., Zhang, C. Y., Feng, B. F., & Tao, Q. M. (1998). Establishment of a nonradioactive assay for 2'-5' oligoadenylate synthetase and its application in chronic hepatitis C patients receiving interferon-alpha. World journal of gastroenterology, 4(1), 70-73. https://doi.org/10.3748/wjg.v4.i1.70
Tong, Wen-Bin, et al. "Establishment of a nonradioactive assay for 2'-5' oligoadenylate synthetase and its application in chronic hepatitis C patients receiving interferon-alpha." World journal of gastroenterology vol. 4,1 (1998): 70-73. doi: https://doi.org/10.3748/wjg.v4.i1.70
Tong WB, Zhang CY, Feng BF, Tao QM. Establishment of a nonradioactive assay for 2'-5' oligoadenylate synthetase and its application in chronic hepatitis C patients receiving interferon-alpha. World J Gastroenterol. 1998 Feb;4(1):70-73. doi: 10.3748/wjg.v4.i1.70. PMID: 11819237; PMCID: PMC4767771.
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Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs.

Proceedings of the National Academy of Sciences of the United States of America

Schwartz SL, Dey D, Tanquary J, Bair CR, Lowen AC, Conn GL.
PMID: 35017296
Proc Natl Acad Sci U S A. 2022 Jan 18;119(3). doi: 10.1073/pnas.2107111119.

The 2'-5'-oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) that play a critical role in limiting viral infection. How these proteins are able to avoid aberrant activation by cellular RNAs is not fully understood, but...

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Schwartz SL, Dey D, Tanquary J, et al. Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs. Proc Natl Acad Sci U S A. 2022;119(3)doi: 10.1073/pnas.2107111119.
Schwartz, S. L., Dey, D., Tanquary, J., Bair, C. R., Lowen, A. C., & Conn, G. L. (2022). Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs. Proceedings of the National Academy of Sciences of the United States of America, 119(3), . https://doi.org/10.1073/pnas.2107111119
Schwartz, Samantha L, et al. "Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs." Proceedings of the National Academy of Sciences of the United States of America vol. 119,3 (2022). doi: https://doi.org/10.1073/pnas.2107111119
Schwartz SL, Dey D, Tanquary J, Bair CR, Lowen AC, Conn GL. Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3). doi: 10.1073/pnas.2107111119. PMID: 35017296.
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Immunity in Different Types of Hepatitis C.

Russian journal of immunology : RJI : official journal of Russian Society of Immunology

Nikolaeva LN, Olenina LV, Kolesanova EF.
PMID: 12687117
Russ J Immunol. 1999 Jul;4(2):91-112.

Hepatitis C virus (HCV) represents serious threat for human health due to a very high probability for developing chronic liver diseases. The virus has a number peculiarities, which helps him to escape elimination by neutralizing antibodies and immune cells....

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Nikolaeva LN, Olenina LV, Kolesanova EF. Immunity in Different Types of Hepatitis C. Russ J Immunol. 1999;4(2):91-112
Nikolaeva, L. N., Olenina, L. V., & Kolesanova, E. F. (1999). Immunity in Different Types of Hepatitis C. Russian journal of immunology : RJI : official journal of Russian Society of Immunology, 4(2), 91-112.
Nikolaeva, Lyudmila N., et al. "Immunity in Different Types of Hepatitis C." Russian journal of immunology : RJI : official journal of Russian Society of Immunology vol. 4,2 (1999): 91-112.
Nikolaeva LN, Olenina LV, Kolesanova EF. Immunity in Different Types of Hepatitis C. Russ J Immunol. 1999 Jul;4(2):91-112. PMID: 12687117.
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Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes.

World journal of biological chemistry

Bogdanova OV, Kot LI, Lavrova KV, Bogdanov VB, Sloan EK, Beregova TV, Ostapchenko LI.
PMID: 21537468
World J Biol Chem. 2010 Nov 26;1(11):338-47. doi: 10.4331/wjbc.v1.i11.338.

AIM: To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration.METHODS: Gastric lesions were induced in rats using restraint cold stress. To investigate the effect of oxidative and nitrosative cell stress on tyrosine...

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Bogdanova OV, Kot LI, Lavrova KV, et al. Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes. World J Biol Chem. 2010;1(11):338-47doi: 10.4331/wjbc.v1.i11.338.
Bogdanova, O. V., Kot, L. I., Lavrova, K. V., Bogdanov, V. B., Sloan, E. K., Beregova, T. V., & Ostapchenko, L. I. (2010). Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes. World journal of biological chemistry, 1(11), 338-47. https://doi.org/10.4331/wjbc.v1.i11.338
Bogdanova, Olena V, et al. "Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes." World journal of biological chemistry vol. 1,11 (2010): 338-47. doi: https://doi.org/10.4331/wjbc.v1.i11.338
Bogdanova OV, Kot LI, Lavrova KV, Bogdanov VB, Sloan EK, Beregova TV, Ostapchenko LI. Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes. World J Biol Chem. 2010 Nov 26;1(11):338-47. doi: 10.4331/wjbc.v1.i11.338. PMID: 21537468; PMCID: PMC3083939.
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Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound.

World journal of biological chemistry

Yu Z, Predina JD, Cheng G.
PMID: 23710296
World J Biol Chem. 2013 May 26;4(2):18-29. doi: 10.4331/wjbc.v4.i2.18.

AIM: To explore the possibility that nucleotide oligomerization domain 1 (NOD1) pathway involved in refractoriness of interferon-β signaling in mouse respiratory epithelial cells induced by the anticancer xanthone compound, 5,6-dimethylxanthenone-4-acetic acid (DMXAA).METHODS: C10 mouse bronchial epithelial cells were grown...

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Yu Z, Predina JD, Cheng G. Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound. World J Biol Chem. 2013;4(2):18-29doi: 10.4331/wjbc.v4.i2.18.
Yu, Z., Predina, J. D., & Cheng, G. (2013). Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound. World journal of biological chemistry, 4(2), 18-29. https://doi.org/10.4331/wjbc.v4.i2.18
Yu, Zaifang, et al. "Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound." World journal of biological chemistry vol. 4,2 (2013): 18-29. doi: https://doi.org/10.4331/wjbc.v4.i2.18
Yu Z, Predina JD, Cheng G. Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound. World J Biol Chem. 2013 May 26;4(2):18-29. doi: 10.4331/wjbc.v4.i2.18. PMID: 23710296; PMCID: PMC3652647.
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Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival.

Experimental and therapeutic medicine

Zhang M, Lv X, Jiang Y, Li G, Qiao Q.
PMID: 31452706
Exp Ther Med. 2019 Sep;18(3):2140-2152. doi: 10.3892/etm.2019.7807. Epub 2019 Jul 24.

Glioblastoma multiforme (GBM) is the most malignant primary tumour type of the central nervous system with limited therapeutic options and poor prognosis, and its pathogenic mechanisms have remained to be fully elucidated. Aberrant DNA methylation is involved in multiple...

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Zhang M, Lv X, Jiang Y, et al. Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival. Exp Ther Med. 2019;18(3):2140-2152doi: 10.3892/etm.2019.7807.
Zhang, M., Lv, X., Jiang, Y., Li, G., & Qiao, Q. (2019). Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival. Experimental and therapeutic medicine, 18(3), 2140-2152. https://doi.org/10.3892/etm.2019.7807
Zhang, Miao, et al. "Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival." Experimental and therapeutic medicine vol. 18,3 (2019): 2140-2152. doi: https://doi.org/10.3892/etm.2019.7807
Zhang M, Lv X, Jiang Y, Li G, Qiao Q. Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival. Exp Ther Med. 2019 Sep;18(3):2140-2152. doi: 10.3892/etm.2019.7807. Epub 2019 Jul 24. PMID: 31452706; PMCID: PMC6704589.
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Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration.

European journal of neurology

Buraglio M, Munafo A, Nguyen TX, Trinchard-Lugan I.
PMID: 10210831
Eur J Neurol. 1998 Mar;5(2):187-193. doi: 10.1046/j.1468-1331.1998.520187.x.

The pharmacokinetics and pharmacodynamics of recombinant human interferon beta (IFN-beta-1a) were compared after intramuscular administration of two preparations (Rebif(R) and AvonexTM) and subcutaneous administration of Rebif(R). Healthy volunteers (n = 30) received a single dose (60 µg) of each...

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Buraglio M, Munafo A, Nguyen TX, et al. Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration. Eur J Neurol. 1998;5(2):187-193doi: 10.1046/j.1468-1331.1998.520187.x.
Buraglio, M., Munafo, A., Nguyen, T. X., & Trinchard-Lugan, I. (1998). Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration. European journal of neurology, 5(2), 187-193. https://doi.org/10.1046/j.1468-1331.1998.520187.x
Buraglio, et al. "Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration." European journal of neurology vol. 5,2 (1998): 187-193. doi: https://doi.org/10.1046/j.1468-1331.1998.520187.x
Buraglio M, Munafo A, Nguyen TX, Trinchard-Lugan I. Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration. Eur J Neurol. 1998 Mar;5(2):187-193. doi: 10.1046/j.1468-1331.1998.520187.x. PMID: 10210831.
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Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia.

Bioengineered

Zhou H, Jia X, Yang F, Shi P.
PMID: 34516354
Bioengineered. 2021 Dec;12(1):6403-6417. doi: 10.1080/21655979.2021.1971508.

Acute myeloid leukemia (AML) represents a hematopoietic cancer with an invasive property. Chemoresistance blunts the therapeutic effect of chemotherapeutics in AML. Long noncoding RNAs (lncRNAs) have been implicated in chemotherapy resistance in AML. Transcriptome sequencing in the current study...

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Zhou H, Jia X, Yang F, et al. Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia. Bioengineered. 2021;12(1):6403-6417doi: 10.1080/21655979.2021.1971508.
Zhou, H., Jia, X., Yang, F., & Shi, P. (2021). Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia. Bioengineered, 12(1), 6403-6417. https://doi.org/10.1080/21655979.2021.1971508
Zhou, Hong, et al. "Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia." Bioengineered vol. 12,1 (2021): 6403-6417. doi: https://doi.org/10.1080/21655979.2021.1971508
Zhou H, Jia X, Yang F, Shi P. Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia. Bioengineered. 2021 Dec;12(1):6403-6417. doi: 10.1080/21655979.2021.1971508. PMID: 34516354.
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Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8.

Hepatology research : the official journal of the Japan Society of Hepatology

Yamamoto S, Yano H, Sanou O, Ikegami H, Kurimoto M, Kojiro M.
PMID: 12270738
Hepatol Res. 2002 Oct;24(2):99. doi: 10.1016/s1386-6346(02)00020-7.

We have studied the antiviral activities of five recombinant interferon-alpha (IFN-alpha) subtypes, namely IFN-alpha1, -alpha2, -alpha5, -alpha8 and -alpha10, in eight human liver cancer cell lines. The relative antiviral activities, expressed in terms of the mean 50% inhibitory concentration...

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Yamamoto S, Yano H, Sanou O, et al. Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8. Hepatol Res. 2002;24(2):99doi: 10.1016/s1386-6346(02)00020-7.
Yamamoto, S., Yano, H., Sanou, O., Ikegami, H., Kurimoto, M., & Kojiro, M. (2002). Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8. Hepatology research : the official journal of the Japan Society of Hepatology, 24(2), 99. https://doi.org/10.1016/s1386-6346(02)00020-7
Yamamoto, Shigeto, et al. "Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8." Hepatology research : the official journal of the Japan Society of Hepatology vol. 24,2 (2002): 99. doi: https://doi.org/10.1016/s1386-6346(02)00020-7
Yamamoto S, Yano H, Sanou O, Ikegami H, Kurimoto M, Kojiro M. Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8. Hepatol Res. 2002 Oct;24(2):99. doi: 10.1016/s1386-6346(02)00020-7. PMID: 12270738.
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Showing 13 to 24 of 37 entries