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Showing 13 to 24 of 39 entries
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"ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells.

Kidney international

Mehta YR, Lewis SA, Leo KT, Chen L, Park E, Raghuram V, Chou CL, Yang CR, Kikuchi H, Khundmiri S, Poll BG, Knepper MA.
PMID: 34757121
Kidney Int. 2021 Oct 29; doi: 10.1016/j.kint.2021.10.014. Epub 2021 Oct 29.

The regulation of cyclic adenosine monophosphate (cAMP) levels in kidney epithelial cells is important in at least 2 groups of disorders, namely water balance disorders and autosomal dominant polycystic kidney disease. Focusing on the latter, we review genes that...

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Mehta YR, Lewis SA, Leo KT, et al. "ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells. Kidney Int. 2021;doi: 10.1016/j.kint.2021.10.014.
Mehta, Y. R., Lewis, S. A., Leo, K. T., Chen, L., Park, E., Raghuram, V., Chou, C. L., Yang, C. R., Kikuchi, H., Khundmiri, S., Poll, B. G., & Knepper, M. A. (2021). "ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells. Kidney international, . https://doi.org/10.1016/j.kint.2021.10.014
Mehta, Yash R, et al. ""ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells." Kidney international vol. (2021). doi: https://doi.org/10.1016/j.kint.2021.10.014
Mehta YR, Lewis SA, Leo KT, Chen L, Park E, Raghuram V, Chou CL, Yang CR, Kikuchi H, Khundmiri S, Poll BG, Knepper MA. "ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells. Kidney Int. 2021 Oct 29; doi: 10.1016/j.kint.2021.10.014. Epub 2021 Oct 29. PMID: 34757121.
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Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.

Physiological reviews

Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS.
PMID: 34698552
Physiol Rev. 2022 Apr 01;102(2):815-857. doi: 10.1152/physrev.00013.2021. Epub 2021 Oct 26.

Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The transmembrane ACs display varying...

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Ostrom KF, LaVigne JE, Brust TF, et al. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiol Rev. 2021;102(2):815-857doi: 10.1152/physrev.00013.2021.
Ostrom, K. F., LaVigne, J. E., Brust, T. F., Seifert, R., Dessauer, C. W., Watts, V. J., & Ostrom, R. S. (2022). Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiological reviews, 102(2), 815-857. https://doi.org/10.1152/physrev.00013.2021
Ostrom, Katrina F, et al. "Physiological roles of mammalian transmembrane adenylyl cyclase isoforms." Physiological reviews vol. 102,2 (2022): 815-857. doi: https://doi.org/10.1152/physrev.00013.2021
Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiol Rev. 2022 Apr 01;102(2):815-857. doi: 10.1152/physrev.00013.2021. Epub 2021 Oct 26. PMID: 34698552.
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Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases.

RSC chemical biology

Tanwar M, Kateriya S, Nair D, Jose M.
PMID: 34458814
RSC Chem Biol. 2021 Mar 08;2(3):863-875. doi: 10.1039/d0cb00124d. eCollection 2021 Jun 01.

Adenosine 3',5'-cyclic monophosphate (cAMP) is a key second messenger that activates several signal transduction pathways in eukaryotic cells. Alteration of basal levels of cAMP is known to activate protein kinases, regulate phosphodiesterases and modulate the activity of ion channels...

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Tanwar M, Kateriya S, Nair D, et al. Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases. RSC Chem Biol. 2021;2(3):863-875doi: 10.1039/d0cb00124d.
Tanwar, M., Kateriya, S., Nair, D., & Jose, M. (2021). Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases. RSC chemical biology, 2(3), 863-875. https://doi.org/10.1039/d0cb00124d
Tanwar, Meenakshi, et al. "Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases." RSC chemical biology vol. 2,3 (2021): 863-875. doi: https://doi.org/10.1039/d0cb00124d
Tanwar M, Kateriya S, Nair D, Jose M. Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases. RSC Chem Biol. 2021 Mar 08;2(3):863-875. doi: 10.1039/d0cb00124d. eCollection 2021 Jun 01. PMID: 34458814; PMCID: PMC8341789.
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Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy.

Neurobiology of pain (Cambridge, Mass.)

Shiers S, Elahi H, Hennen S, Price TJ.
PMID: 35005298
Neurobiol Pain. 2021 Dec 21;11:100081. doi: 10.1016/j.ynpai.2021.100081. eCollection 2022.

The anterior cingulate cortex (ACC) is a critical region of the brain for the emotional and affective components of pain in rodents and humans. Hyperactivity in this region has been observed in neuropathic pain states in both patients and...

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Shiers S, Elahi H, Hennen S, et al. Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy. Neurobiol Pain. 2021;11:100081doi: 10.1016/j.ynpai.2021.100081.
Shiers, S., Elahi, H., Hennen, S., & Price, T. J. (2022). Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy. Neurobiology of pain (Cambridge, Mass.), 11100081. https://doi.org/10.1016/j.ynpai.2021.100081
Shiers, Stephanie, et al. "Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy." Neurobiology of pain (Cambridge, Mass.) vol. 11 (2022): 100081. doi: https://doi.org/10.1016/j.ynpai.2021.100081
Shiers S, Elahi H, Hennen S, Price TJ. Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with spared nerve injury neuropathy. Neurobiol Pain. 2021 Dec 21;11:100081. doi: 10.1016/j.ynpai.2021.100081. eCollection 2022. PMID: 35005298; PMCID: PMC8715370.
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Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.

Physiological reviews

Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS.
PMID: 34698552
Physiol Rev. 2022 Apr 01;102(2):815-857. doi: 10.1152/physrev.00013.2021. Epub 2021 Oct 26.

Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The transmembrane ACs display varying...

Cite
Ostrom KF, LaVigne JE, Brust TF, et al. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiol Rev. 2021;102(2):815-857doi: 10.1152/physrev.00013.2021.
Ostrom, K. F., LaVigne, J. E., Brust, T. F., Seifert, R., Dessauer, C. W., Watts, V. J., & Ostrom, R. S. (2022). Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiological reviews, 102(2), 815-857. https://doi.org/10.1152/physrev.00013.2021
Ostrom, Katrina F, et al. "Physiological roles of mammalian transmembrane adenylyl cyclase isoforms." Physiological reviews vol. 102,2 (2022): 815-857. doi: https://doi.org/10.1152/physrev.00013.2021
Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiol Rev. 2022 Apr 01;102(2):815-857. doi: 10.1152/physrev.00013.2021. Epub 2021 Oct 26. PMID: 34698552.
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Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.

Pharmaceuticals (Basel, Switzerland)

Oldenburger A, Maarsingh H, Schmidt M.
PMID: 24281338
Pharmaceuticals (Basel). 2012 Nov 30;5(12):1291-331. doi: 10.3390/ph5121291.

Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD). Characteristics of COPD are airway obstruction, airway inflammation and airway remodelling, processes...

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Oldenburger A, Maarsingh H, Schmidt M. Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharmaceuticals (Basel). 2012;5(12):1291-331doi: 10.3390/ph5121291.
Oldenburger, A., Maarsingh, H., & Schmidt, M. (2012). Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharmaceuticals (Basel, Switzerland), 5(12), 1291-331. https://doi.org/10.3390/ph5121291
Oldenburger, Anouk, et al. "Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung." Pharmaceuticals (Basel, Switzerland) vol. 5,12 (2012): 1291-331. doi: https://doi.org/10.3390/ph5121291
Oldenburger A, Maarsingh H, Schmidt M. Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharmaceuticals (Basel). 2012 Nov 30;5(12):1291-331. doi: 10.3390/ph5121291. PMID: 24281338; PMCID: PMC3816672.
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Can intracellular cAMP dynamics enable scalable computation?.

Frontiers in cellular neuroscience

Iyengar R.
PMID: 25870541
Front Cell Neurosci. 2015 Mar 27;9:112. doi: 10.3389/fncel.2015.00112. eCollection 2015.

No abstract available.

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Iyengar R. Can intracellular cAMP dynamics enable scalable computation?. Front Cell Neurosci. 2015;9:112doi: 10.3389/fncel.2015.00112.
Iyengar, R. (2015). Can intracellular cAMP dynamics enable scalable computation?. Frontiers in cellular neuroscience, 9112. https://doi.org/10.3389/fncel.2015.00112
Iyengar, Ravi. "Can intracellular cAMP dynamics enable scalable computation?." Frontiers in cellular neuroscience vol. 9 (2015): 112. doi: https://doi.org/10.3389/fncel.2015.00112
Iyengar R. Can intracellular cAMP dynamics enable scalable computation?. Front Cell Neurosci. 2015 Mar 27;9:112. doi: 10.3389/fncel.2015.00112. eCollection 2015. PMID: 25870541; PMCID: PMC4375975.
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The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!.

Frontiers in pharmacology

Tagoe DN, Kalejaiye TD, de Koning HP.
PMID: 26441645
Front Pharmacol. 2015 Sep 07;6:185. doi: 10.3389/fphar.2015.00185. eCollection 2015.

Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the most serious human diseases, including Chagas disease (Trypanosoma cruzi), sleeping sickness (Trypanosoma brucei spp.), and leishmaniasis...

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Tagoe DN, Kalejaiye TD, de Koning HP. The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!. Front Pharmacol. 2015;6:185doi: 10.3389/fphar.2015.00185.
Tagoe, D. N., Kalejaiye, T. D., & de Koning, H. P. (2015). The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!. Frontiers in pharmacology, 6185. https://doi.org/10.3389/fphar.2015.00185
Tagoe, Daniel N A, et al. "The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!." Frontiers in pharmacology vol. 6 (2015): 185. doi: https://doi.org/10.3389/fphar.2015.00185
Tagoe DN, Kalejaiye TD, de Koning HP. The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!. Front Pharmacol. 2015 Sep 07;6:185. doi: 10.3389/fphar.2015.00185. eCollection 2015. PMID: 26441645; PMCID: PMC4561360.
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Correction: Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells.

The Journal of biological chemistry

Blain-Hartung M, Rockwell NC, Moreno MV, Martin SS, Gan F, Bryant DA, Lagarias JC.
PMID: 30194257
J Biol Chem. 2018 Sep 07;293(36):13850. doi: 10.1074/jbc.AAC118.005397.

No abstract available.

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Blain-Hartung M, Rockwell NC, Moreno MV, et al. Correction: Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. J Biol Chem. 2018;293(36):13850doi: 10.1074/jbc.AAC118.005397.
Blain-Hartung, M., Rockwell, N. C., Moreno, M. V., Martin, S. S., Gan, F., Bryant, D. A., & Lagarias, J. C. (2018). Correction: Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. The Journal of biological chemistry, 293(36), 13850. https://doi.org/10.1074/jbc.AAC118.005397
Blain-Hartung, Matthew, et al. "Correction: Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells." The Journal of biological chemistry vol. 293,36 (2018): 13850. doi: https://doi.org/10.1074/jbc.AAC118.005397
Blain-Hartung M, Rockwell NC, Moreno MV, Martin SS, Gan F, Bryant DA, Lagarias JC. Correction: Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. J Biol Chem. 2018 Sep 07;293(36):13850. doi: 10.1074/jbc.AAC118.005397. PMID: 30194257; PMCID: PMC6130967.
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Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity.

Seminars in cancer biology

Perez DR, Sklar LA, Chigaev A, Matlawska-Wasowska K.
PMID: 32044470
Semin Cancer Biol. 2021 Jan;68:199-208. doi: 10.1016/j.semcancer.2020.02.004. Epub 2020 Feb 07.

While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) pathway has provided a...

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Perez DR, Sklar LA, Chigaev A, et al. Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity. Semin Cancer Biol. 2020;68:199-208doi: 10.1016/j.semcancer.2020.02.004.
Perez, D. R., Sklar, L. A., Chigaev, A., & Matlawska-Wasowska, K. (2021). Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity. Seminars in cancer biology, 68199-208. https://doi.org/10.1016/j.semcancer.2020.02.004
Perez, Dominique R, et al. "Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity." Seminars in cancer biology vol. 68 (2021): 199-208. doi: https://doi.org/10.1016/j.semcancer.2020.02.004
Perez DR, Sklar LA, Chigaev A, Matlawska-Wasowska K. Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity. Semin Cancer Biol. 2021 Jan;68:199-208. doi: 10.1016/j.semcancer.2020.02.004. Epub 2020 Feb 07. PMID: 32044470; PMCID: PMC7415530.
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New Perspectives on Plant Adenylyl Cyclases.

Frontiers in molecular biosciences

Ruzvidzo O, Gehring C, Wong A.
PMID: 31850369
Front Mol Biosci. 2019 Dec 03;6:136. doi: 10.3389/fmolb.2019.00136. eCollection 2019.

It is increasingly clear that plant genomes encode numerous complex multidomain proteins that harbor functional adenylyl cyclase (AC) centers. These AC containing proteins have well-documented roles in development and responses to the environment. However, it is only for a...

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Ruzvidzo O, Gehring C, Wong A. New Perspectives on Plant Adenylyl Cyclases. Front Mol Biosci. 2019;6:136doi: 10.3389/fmolb.2019.00136.
Ruzvidzo, O., Gehring, C., & Wong, A. (2019). New Perspectives on Plant Adenylyl Cyclases. Frontiers in molecular biosciences, 6136. https://doi.org/10.3389/fmolb.2019.00136
Ruzvidzo, Oziniel, et al. "New Perspectives on Plant Adenylyl Cyclases." Frontiers in molecular biosciences vol. 6 (2019): 136. doi: https://doi.org/10.3389/fmolb.2019.00136
Ruzvidzo O, Gehring C, Wong A. New Perspectives on Plant Adenylyl Cyclases. Front Mol Biosci. 2019 Dec 03;6:136. doi: 10.3389/fmolb.2019.00136. eCollection 2019. PMID: 31850369; PMCID: PMC6901789.
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New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway.

Frontiers in pharmacology

Godinho RO, Duarte T, Pacini ES.
PMID: 25859216
Front Pharmacol. 2015 Mar 24;6:58. doi: 10.3389/fphar.2015.00058. eCollection 2015.

G protein-coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases , which differ considerably in their cellular distribution and activation mechanisms. Once produced, cyclic...

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Godinho RO, Duarte T, Pacini ES. New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway. Front Pharmacol. 2015;6:58doi: 10.3389/fphar.2015.00058.
Godinho, R. O., Duarte, T., & Pacini, E. S. (2015). New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway. Frontiers in pharmacology, 658. https://doi.org/10.3389/fphar.2015.00058
Godinho, Rosely O, et al. "New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway." Frontiers in pharmacology vol. 6 (2015): 58. doi: https://doi.org/10.3389/fphar.2015.00058
Godinho RO, Duarte T, Pacini ES. New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway. Front Pharmacol. 2015 Mar 24;6:58. doi: 10.3389/fphar.2015.00058. eCollection 2015. PMID: 25859216; PMCID: PMC4373373.
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Showing 13 to 24 of 39 entries