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The use of in vitro methods for studying drug metabolism to replace animal studies as part of veterinary medicines product licence applications.

Toxicology in vitro : an international journal published in association with BIBRA

Shaw IC.
PMID: 20693043
Toxicol In Vitro. 1994 Aug;8(4):917-9. doi: 10.1016/0887-2333(94)90099-x.

It is currently necessary to carry out drug metabolism studies in the target species as part of veterinary Product Licence Applications (PLA). Such studies use large numbers of animals. Studies with pig and rat liver homogenates obtained from animals...

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Shaw IC. The use of in vitro methods for studying drug metabolism to replace animal studies as part of veterinary medicines product licence applications. Toxicol In Vitro. 1994;8(4):917-9doi: 10.1016/0887-2333(94)90099-x.
Shaw, I. C. (1994). The use of in vitro methods for studying drug metabolism to replace animal studies as part of veterinary medicines product licence applications. Toxicology in vitro : an international journal published in association with BIBRA, 8(4), 917-9. https://doi.org/10.1016/0887-2333(94)90099-x
Shaw, I C. "The use of in vitro methods for studying drug metabolism to replace animal studies as part of veterinary medicines product licence applications." Toxicology in vitro : an international journal published in association with BIBRA vol. 8,4 (1994): 917-9. doi: https://doi.org/10.1016/0887-2333(94)90099-x
Shaw IC. The use of in vitro methods for studying drug metabolism to replace animal studies as part of veterinary medicines product licence applications. Toxicol In Vitro. 1994 Aug;8(4):917-9. doi: 10.1016/0887-2333(94)90099-x. PMID: 20693043.
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DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides.

Organic & biomolecular chemistry

Thupyai A, Pimpasri C, Yotphan S.
PMID: 29264609
Org Biomol Chem. 2018 Jan 17;16(3):424-432. doi: 10.1039/c7ob02860a.

A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(i) acetate, the C-S bond formation proceeds smoothly at room temperature under mild and easy to handle...

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Thupyai A, Pimpasri C, Yotphan S. DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides. Org Biomol Chem. 2018;16(3):424-432doi: 10.1039/c7ob02860a.
Thupyai, A., Pimpasri, C., & Yotphan, S. (2018). DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides. Organic & biomolecular chemistry, 16(3), 424-432. https://doi.org/10.1039/c7ob02860a
Thupyai, Akkharaphong, et al. "DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides." Organic & biomolecular chemistry vol. 16,3 (2018): 424-432. doi: https://doi.org/10.1039/c7ob02860a
Thupyai A, Pimpasri C, Yotphan S. DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides. Org Biomol Chem. 2018 Jan 17;16(3):424-432. doi: 10.1039/c7ob02860a. PMID: 29264609.
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Design, synthesis and biological evaluation of novel antipyrine based α-aminophosphonates as anti-Alzheimer and anti-inflammatory agent.

Journal of biomolecular structure & dynamics

Shaikh S, Dhavan P, Singh P, Uparkar J, Vaidya SP, Jadhav BL, Ramana MMV.
PMID: 34878960
J Biomol Struct Dyn. 2021 Dec 08;1-16. doi: 10.1080/07391102.2021.2006088. Epub 2021 Dec 08.

Herein, a series of novel antipyrine based α-aminophosphonates derivatives were synthesized and characterized. The synthesized derivatives were subjected for

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Shaikh S, Dhavan P, Singh P, et al. Design, synthesis and biological evaluation of novel antipyrine based α-aminophosphonates as anti-Alzheimer and anti-inflammatory agent. J Biomol Struct Dyn. 2021;1-16doi: 10.1080/07391102.2021.2006088.
Shaikh, S., Dhavan, P., Singh, P., Uparkar, J., Vaidya, S. P., Jadhav, B. L., & Ramana, M. M. V. (2021). Design, synthesis and biological evaluation of novel antipyrine based α-aminophosphonates as anti-Alzheimer and anti-inflammatory agent. Journal of biomolecular structure & dynamics, 1-16. https://doi.org/10.1080/07391102.2021.2006088
Shaikh, Sarfaraz, et al. "Design, synthesis and biological evaluation of novel antipyrine based α-aminophosphonates as anti-Alzheimer and anti-inflammatory agent." Journal of biomolecular structure & dynamics vol. (2021): 1-16. doi: https://doi.org/10.1080/07391102.2021.2006088
Shaikh S, Dhavan P, Singh P, Uparkar J, Vaidya SP, Jadhav BL, Ramana MMV. Design, synthesis and biological evaluation of novel antipyrine based α-aminophosphonates as anti-Alzheimer and anti-inflammatory agent. J Biomol Struct Dyn. 2021 Dec 08;1-16. doi: 10.1080/07391102.2021.2006088. Epub 2021 Dec 08. PMID: 34878960.
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A simple and rapid determination of Al(III) in natural water samples using dispersive liquid-liquid microextraction after complexation with a novel antipyrine-based Schiff base reagent.

Environmental monitoring and assessment

Karuk Elmas SN.
PMID: 34970705
Environ Monit Assess. 2021 Dec 31;194(1):47. doi: 10.1007/s10661-021-09701-y.

The purpose of this study is the development of a novel strategy for the determination of Al

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Karuk Elmas SN. A simple and rapid determination of Al(III) in natural water samples using dispersive liquid-liquid microextraction after complexation with a novel antipyrine-based Schiff base reagent. Environ Monit Assess. 2021;194(1):47doi: 10.1007/s10661-021-09701-y.
Karuk Elmas, S. N. (2021). A simple and rapid determination of Al(III) in natural water samples using dispersive liquid-liquid microextraction after complexation with a novel antipyrine-based Schiff base reagent. Environmental monitoring and assessment, 194(1), 47. https://doi.org/10.1007/s10661-021-09701-y
Karuk Elmas, Sukriye Nihan. "A simple and rapid determination of Al(III) in natural water samples using dispersive liquid-liquid microextraction after complexation with a novel antipyrine-based Schiff base reagent." Environmental monitoring and assessment vol. 194,1 (2021): 47. doi: https://doi.org/10.1007/s10661-021-09701-y
Karuk Elmas SN. A simple and rapid determination of Al(III) in natural water samples using dispersive liquid-liquid microextraction after complexation with a novel antipyrine-based Schiff base reagent. Environ Monit Assess. 2021 Dec 31;194(1):47. doi: 10.1007/s10661-021-09701-y. PMID: 34970705.
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Brief report: Body water estimates in normally grown baboon neonates.

American journal of primatology

Brans YW, Kuehl TJ, Hayashi RH, Shannon DL, Reyes P.
PMID: 31992012
Am J Primatol. 1983;5(1):69-75. doi: 10.1002/ajp.1350050108.

Water contents of various body water compartments were estimated within nine hours of birth in 11 preterm and eight term baboon (Papio cynocephalus neonates. Estimated water contents of all body compartments (in ml) increased linearly with birthweight (r =...

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Brans YW, Kuehl TJ, Hayashi RH, et al. Brief report: Body water estimates in normally grown baboon neonates. Am J Primatol. 1983;5(1):69-75doi: 10.1002/ajp.1350050108.
Brans, Y. W., Kuehl, T. J., Hayashi, R. H., Shannon, D. L., & Reyes, P. (1983). Brief report: Body water estimates in normally grown baboon neonates. American journal of primatology, 5(1), 69-75. https://doi.org/10.1002/ajp.1350050108
Brans, Yves W, et al. "Brief report: Body water estimates in normally grown baboon neonates." American journal of primatology vol. 5,1 (1983): 69-75. doi: https://doi.org/10.1002/ajp.1350050108
Brans YW, Kuehl TJ, Hayashi RH, Shannon DL, Reyes P. Brief report: Body water estimates in normally grown baboon neonates. Am J Primatol. 1983;5(1):69-75. doi: 10.1002/ajp.1350050108. PMID: 31992012.
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Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans.

Current drug metabolism

De-Oliveira ACAX, Paumgartten FJR.
PMID: 33397251
Curr Drug Metab. 2021;22(2):127-138. doi: 10.2174/1389200221999210101232057.

BACKGROUND: Infections and inflammation lead to a downregulation of drug metabolism and kinetics in experimental animals. These changes in the expression and activities of drug-metabolizing enzymes may affect the effectiveness and safety of pharmacotherapy of infections and inflammatory conditions.OBJECTIVE:...

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De-Oliveira ACAX, Paumgartten FJR. Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans. Curr Drug Metab. 2021;22(2):127-138doi: 10.2174/1389200221999210101232057.
De-Oliveira, A. C. A. X., & Paumgartten, F. J. R. (2021). Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans. Current drug metabolism, 22(2), 127-138. https://doi.org/10.2174/1389200221999210101232057
De-Oliveira, Ana C A X, and Paumgartten, Francisco J R. "Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans." Current drug metabolism vol. 22,2 (2021): 127-138. doi: https://doi.org/10.2174/1389200221999210101232057
De-Oliveira ACAX, Paumgartten FJR. Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans. Curr Drug Metab. 2021;22(2):127-138. doi: 10.2174/1389200221999210101232057. PMID: 33397251.
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The Effects of Lansoprazole on the Disposition of Antipyrine and Indocyanine Green in Normal Human Subjects.

American journal of therapeutics

St Peter JV, Awni WM, Granneman GR, Karol MD.
PMID: 11854827
Am J Ther. 1995 Aug;2(8):561-568. doi: 10.1097/00045391-199508000-00008.

This study was designed to evaluate the potential effects of acute and chronic daily oral doses of lansoprazole (60 mg) on the disposition of antipyrine, an almost completely metabolized low hepatic extraction compound, and indocyanine green, a hepatically secreted...

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St Peter JV, Awni WM, Granneman GR, et al. The Effects of Lansoprazole on the Disposition of Antipyrine and Indocyanine Green in Normal Human Subjects. Am J Ther. 1995;2(8):561-568doi: 10.1097/00045391-199508000-00008.
St Peter, J. V., Awni, W. M., Granneman, G. R., & Karol, M. D. (1995). The Effects of Lansoprazole on the Disposition of Antipyrine and Indocyanine Green in Normal Human Subjects. American journal of therapeutics, 2(8), 561-568. https://doi.org/10.1097/00045391-199508000-00008
St Peter, John V., et al. "The Effects of Lansoprazole on the Disposition of Antipyrine and Indocyanine Green in Normal Human Subjects." American journal of therapeutics vol. 2,8 (1995): 561-568. doi: https://doi.org/10.1097/00045391-199508000-00008
St Peter JV, Awni WM, Granneman GR, Karol MD. The Effects of Lansoprazole on the Disposition of Antipyrine and Indocyanine Green in Normal Human Subjects. Am J Ther. 1995 Aug;2(8):561-568. doi: 10.1097/00045391-199508000-00008. PMID: 11854827.
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An antipyrine based fluorescence "turn-on" dual sensor for Zn.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Dey S, Maity A, Shyamal M, Das D, Maity S, Giri PK, Mudi N, Samanta SS, Hazra P, Misra A.
PMID: 31560015
Photochem Photobiol Sci. 2019 Nov 06;18(11):2717-2729. doi: 10.1039/c9pp00226j.

A 2,6-diformyl-p-cresol (DFC)-4-amino antipyrine (AP) based dual signaling fluorescent Schiff base ligand (DFCAP) is found to exhibit colorimetric and fluorescence turn on selective sensing towards metal ions, Zn2+ and Al3+. It also exhibits a significant aggregation induced emission (AIE)...

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Dey S, Maity A, Shyamal M, et al. An antipyrine based fluorescence "turn-on" dual sensor for Zn. Photochem Photobiol Sci. 2019;18(11):2717-2729doi: 10.1039/c9pp00226j.
Dey, S., Maity, A., Shyamal, M., Das, D., Maity, S., Giri, P. K., Mudi, N., Samanta, S. S., Hazra, P., & Misra, A. (2019). An antipyrine based fluorescence "turn-on" dual sensor for Zn. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 18(11), 2717-2729. https://doi.org/10.1039/c9pp00226j
Dey, Sudipto, et al. "An antipyrine based fluorescence "turn-on" dual sensor for Zn." Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology vol. 18,11 (2019): 2717-2729. doi: https://doi.org/10.1039/c9pp00226j
Dey S, Maity A, Shyamal M, Das D, Maity S, Giri PK, Mudi N, Samanta SS, Hazra P, Misra A. An antipyrine based fluorescence "turn-on" dual sensor for Zn. Photochem Photobiol Sci. 2019 Nov 06;18(11):2717-2729. doi: 10.1039/c9pp00226j. PMID: 31560015.
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Determination of the Transplacental Transfer of Paclitaxel and Antipyrine by High Performance Liquid Chromatography Coupled with Photodiode Array Detector.

Journal of liquid chromatography & related technologies

Ali S, Albekairi N, Wang XM, Patrikeeva S, Nanovskaya TN, Ahmed MS, Rytting E.
PMID: 30774296
J Liq Chromatogr Relat Technol. 2018;41(5):232-238. doi: 10.1080/10826076.2018.1436068. Epub 2018 Feb 26.

No abstract available.

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Ali S, Albekairi N, Wang XM, et al. Determination of the Transplacental Transfer of Paclitaxel and Antipyrine by High Performance Liquid Chromatography Coupled with Photodiode Array Detector. J Liq Chromatogr Relat Technol. 2018;41(5):232-238doi: 10.1080/10826076.2018.1436068.
Ali, S., Albekairi, N., Wang, X. M., Patrikeeva, S., Nanovskaya, T. N., Ahmed, M. S., & Rytting, E. (2018). Determination of the Transplacental Transfer of Paclitaxel and Antipyrine by High Performance Liquid Chromatography Coupled with Photodiode Array Detector. Journal of liquid chromatography & related technologies, 41(5), 232-238. https://doi.org/10.1080/10826076.2018.1436068
Ali, Shariq, et al. "Determination of the Transplacental Transfer of Paclitaxel and Antipyrine by High Performance Liquid Chromatography Coupled with Photodiode Array Detector." Journal of liquid chromatography & related technologies vol. 41,5 (2018): 232-238. doi: https://doi.org/10.1080/10826076.2018.1436068
Ali S, Albekairi N, Wang XM, Patrikeeva S, Nanovskaya TN, Ahmed MS, Rytting E. Determination of the Transplacental Transfer of Paclitaxel and Antipyrine by High Performance Liquid Chromatography Coupled with Photodiode Array Detector. J Liq Chromatogr Relat Technol. 2018;41(5):232-238. doi: 10.1080/10826076.2018.1436068. Epub 2018 Feb 26. PMID: 30774296; PMCID: PMC6374044.
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Surgical Extracts-Gall Bladder Surgery - Antipyrine in Painful Affections of the Bladder and Prostate - Fracture of the Patella, &c.

The Indian medical gazette

Pilgrim HW.
PMID: 29001652
Ind Med Gaz. 1894 Nov;29(11):432-433.

No abstract available.

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Pilgrim HW. Surgical Extracts-Gall Bladder Surgery - Antipyrine in Painful Affections of the Bladder and Prostate - Fracture of the Patella, &c. Ind Med Gaz. 1894;29(11):432-433
Pilgrim, H. W. (1894). Surgical Extracts-Gall Bladder Surgery - Antipyrine in Painful Affections of the Bladder and Prostate - Fracture of the Patella, &c. The Indian medical gazette, 29(11), 432-433.
Pilgrim, H W. "Surgical Extracts-Gall Bladder Surgery - Antipyrine in Painful Affections of the Bladder and Prostate - Fracture of the Patella, &c." The Indian medical gazette vol. 29,11 (1894): 432-433.
Pilgrim HW. Surgical Extracts-Gall Bladder Surgery - Antipyrine in Painful Affections of the Bladder and Prostate - Fracture of the Patella, &c. Ind Med Gaz. 1894 Nov;29(11):432-433. PMID: 29001652; PMCID: PMC5197399.
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Obstetrics, Gynæcology, and Pædiatrics: Antipyrine as an Anti-Galactagogue-Hyperemesis Gravidarum-Quinine during Labour-Toxic Materials Absorbed from the Bowel as a Cause of Version of the Uterus-Apnœa of Premature Infants-On the Use of Senecio in Disorders of Menstruation-Phenacetin for Pain in Cancer of the Uterus-Airol in Ophthalmia Neonatorum-New Methods of Resuscitating Still-Born and Feeble-Born Infants.

The Indian medical gazette

Das K.
PMID: 29001769
Ind Med Gaz. 1898 Feb;33(2):70-72.

No abstract available.

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Das K. Obstetrics, Gynæcology, and Pædiatrics: Antipyrine as an Anti-Galactagogue-Hyperemesis Gravidarum-Quinine during Labour-Toxic Materials Absorbed from the Bowel as a Cause of Version of the Uterus-Apnœa of Premature Infants-On the Use of Senecio in Disorders of Menstruation-Phenacetin for Pain in Cancer of the Uterus-Airol in Ophthalmia Neonatorum-New Methods of Resuscitating Still-Born and Feeble-Born Infants. Ind Med Gaz. 1898;33(2):70-72
Das, K. (1898). Obstetrics, Gynæcology, and Pædiatrics: Antipyrine as an Anti-Galactagogue-Hyperemesis Gravidarum-Quinine during Labour-Toxic Materials Absorbed from the Bowel as a Cause of Version of the Uterus-Apnœa of Premature Infants-On the Use of Senecio in Disorders of Menstruation-Phenacetin for Pain in Cancer of the Uterus-Airol in Ophthalmia Neonatorum-New Methods of Resuscitating Still-Born and Feeble-Born Infants. The Indian medical gazette, 33(2), 70-72.
Das, Kedarnath. "Obstetrics, Gynæcology, and Pædiatrics: Antipyrine as an Anti-Galactagogue-Hyperemesis Gravidarum-Quinine during Labour-Toxic Materials Absorbed from the Bowel as a Cause of Version of the Uterus-Apnœa of Premature Infants-On the Use of Senecio in Disorders of Menstruation-Phenacetin for Pain in Cancer of the Uterus-Airol in Ophthalmia Neonatorum-New Methods of Resuscitating Still-Born and Feeble-Born Infants." The Indian medical gazette vol. 33,2 (1898): 70-72.
Das K. Obstetrics, Gynæcology, and Pædiatrics: Antipyrine as an Anti-Galactagogue-Hyperemesis Gravidarum-Quinine during Labour-Toxic Materials Absorbed from the Bowel as a Cause of Version of the Uterus-Apnœa of Premature Infants-On the Use of Senecio in Disorders of Menstruation-Phenacetin for Pain in Cancer of the Uterus-Airol in Ophthalmia Neonatorum-New Methods of Resuscitating Still-Born and Feeble-Born Infants. Ind Med Gaz. 1898 Feb;33(2):70-72. PMID: 29001769; PMCID: PMC5140970.
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Transplacental transfer of 2-naphthol in human placenta.

Toxicology reports

Mirghani H, Osman N, Dhanasekaran S, Elbiss HM, Bekdache G.
PMID: 28962435
Toxicol Rep. 2015 Jun 18;2:957-960. doi: 10.1016/j.toxrep.2015.05.011. eCollection 2015.

OBJECTIVE: To determine the transfer of 2-naphthol (2-NPH) in fullterm human placental tissues.METHODS: Six placentas were studied. The ex-vivo dual closed-loop human placental cotyledon perfusion model was used. 2-NPH was added to the perfusate in the maternal compartment. Samples...

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Mirghani H, Osman N, Dhanasekaran S, et al. Transplacental transfer of 2-naphthol in human placenta. Toxicol Rep. 2015;2:957-960doi: 10.1016/j.toxrep.2015.05.011.
Mirghani, H., Osman, N., Dhanasekaran, S., Elbiss, H. M., & Bekdache, G. (2015). Transplacental transfer of 2-naphthol in human placenta. Toxicology reports, 2957-960. https://doi.org/10.1016/j.toxrep.2015.05.011
Mirghani, Hisham, et al. "Transplacental transfer of 2-naphthol in human placenta." Toxicology reports vol. 2 (2015): 957-960. doi: https://doi.org/10.1016/j.toxrep.2015.05.011
Mirghani H, Osman N, Dhanasekaran S, Elbiss HM, Bekdache G. Transplacental transfer of 2-naphthol in human placenta. Toxicol Rep. 2015 Jun 18;2:957-960. doi: 10.1016/j.toxrep.2015.05.011. eCollection 2015. PMID: 28962435; PMCID: PMC5598455.
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Showing 13 to 24 of 78 entries