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Showing 6349 to 6358 of 6358 entries
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Metabolic Effects of Growth Hormone Treatment in Short Prepubertal Children: A Double-Blinded Randomized Clinical Trial.

Hormone research in paediatrics

Tidblad A, Gustafsson J, Marcus C, Ritzén M, Ekström K.
PMID: 33684919
Horm Res Paediatr. 2020;93(9):519-528. doi: 10.1159/000513518. Epub 2021 Mar 08.

INTRODUCTION: Growth hormone (GH) is a central hormone for regulating linear growth during childhood and also highly involved in the metabolism of lipids, carbohydrates, and protein. However, few studies report on how treatment with GH during childhood influences metabolic...

Availability of Arg, but Not tRNA, Is a Rate-Limiting Factor for Intracellular Arginylation.

International journal of molecular sciences

Avcilar-Kucukgoze I, MacTaggart B, Kashina A.
PMID: 35008737
Int J Mol Sci. 2021 Dec 28;23(1). doi: 10.3390/ijms23010314.

Protein arginylation, mediated by arginyltransferase ATE1, is a posttranslational modification of emerging biological importance that consists of transfer of the amino acid Arg from tRNA to protein and peptide targets. ATE1 can bind tRNA and exhibits specificity toward particular...

RERE deficiency causes retinal and optic nerve atrophy through degeneration of retinal cells.

Developmental dynamics : an official publication of the American Association of Anatomists

Kim BJ, Scott DA.
PMID: 33742727
Dev Dyn. 2021 Oct;250(10):1398-1409. doi: 10.1002/dvdy.330. Epub 2021 Mar 29.

BACKGROUND: The arginine-glutamic acid dipeptide repeats gene (RERE) encodes a nuclear receptor coregulator that modulates gene expression through its interaction with transcriptional machinery. In humans, RERE deficiency causes neurodevelopmental disorder with or without structural defects of the brain, eye,...

Mimicking LysC Proteolysis by 'Arginine Modification-cum-Trypsin Digestion': Comparison of Bottom-up & Middle-down Proteomic Approaches by ESI Q-TOF MS.

Protein and peptide letters

Pandeswari PB, Chary RN, Kamalanathan AS, Prabhakar S, Sabareesh V.
PMID: 34587878
Protein Pept Lett. 2021;28(12):1379-1390. doi: 10.2174/0929866528666210929163307.

BACKGROUND: Middle-down (MD) proteomics is an emerging approach for reliable identification of post-translational modifications and isoforms, as this approach focuses on proteolytic peptides containing > 25-30 amino acid residues (a.a.r.), which are longer than typical tryptic peptides. Such longer...

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.

Circulation

Raad N, Bittihn P, Cacheux M, Jeong D, Ilkan Z, Ceholski D, Kohlbrenner E, Zhang L, Cai CL, Kranias EG, Hajjar RJ, Stillitano F, Akar FG.
PMID: 34024116
Circulation. 2021 Aug 10;144(6):441-454. doi: 10.1161/CIRCULATIONAHA.119.043502. Epub 2021 May 24.

BACKGROUND: Arginine (Arg) 14 deletion (R14del) in the calcium regulatory protein phospholamban (hPLNMETHODS: To address this, we performed high spatiotemporal resolution optical mapping of intact hearts from adult knock-in mice harboring the human PLNRESULTS: Adverse electrophysiological remodeling was evident...

Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury.

Scientific reports

Soranno DE, Baker P, Kirkbride-Romeo L, Wennersten SA, Ding K, Keith B, Cavasin MA, Altmann C, Bagchi RA, Haefner KR, Montford J, Gist KM, Vergnes L, Reue K, He Z, Elajaili H, Okamura K, Nozik E, McKinsey TA, Faubel S.
PMID: 35022484
Sci Rep. 2022 Jan 12;12(1):643. doi: 10.1038/s41598-021-04701-x.

Acute kidney injury (AKI) is common in patients, causes systemic sequelae, and predisposes patients to long-term cardiovascular disease. To date, studies of the effects of AKI on cardiovascular outcomes have only been performed in male mice. We recently demonstrated...

l-Argine regulates the proliferation, apoptosis and endocrine activity by alleviating oxidative stress in sheep endometrial epithelial cells.

Theriogenology

Gao X, Li X, Wang Z, Li K, Liang Y, Yao X, Zhang G, Wang F.
PMID: 34883396
Theriogenology. 2021 Dec 03;179:187-196. doi: 10.1016/j.theriogenology.2021.12.002. Epub 2021 Dec 03.

l-arginine (L-Arg) is a semiessential amino acid that plays crucial roles in the reproductive performance of animals. This research aimed to investigate the effect of supplementing L-Arg on endometrial epithelial cells (EECs) of Hu sheep. In vivo, female Hu...

Cyclosporin A alleviates trophoblast apoptosis and senescence by promoting autophagy in preeclampsia.

Placenta

Hu H, Chen W, Tao Z, Li Z, He J, Peng Y, Ma J, Wen H, Li J, Wang X, Zhong M.
PMID: 34785431
Placenta. 2021 Nov 12;117:95-108. doi: 10.1016/j.placenta.2021.11.003. Epub 2021 Nov 12.

INTRODUCTION: Abnormal extravillous trophoblast (EVT) function is closely related to preeclampsia (PE) and may be caused by inadequate autophagy, apoptosis, and senescence. Cyclosporin A (CsA) is an effective immunosuppressant that has been reported to stimulate autophagy and exert benign...

Microwave-assisted enzymatic hydrolysis of wheat germ albumin to prepare polypeptides and influence on physical and chemical properties.

Food chemistry

Tian S, Du K, Yan F, Li Y.
PMID: 34896955
Food Chem. 2021 Nov 30;374:131707. doi: 10.1016/j.foodchem.2021.131707. Epub 2021 Nov 30.

Wheat germ albumin (WGA) is rich in nutrients and contains a number of antioxidant polypeptides. The effects of microwave-assisted alkaline protease, neutral protease, papain and compound protease on the degree of hydrolysis of WGA and the clearance rate of...

Cloning and Functional Characterization of an Avian Pituitary Gland Vasotocin Receptor.

[No authors listed]
UIID-NSF: 1215

The hypothalamo-pituitary-adrenal axis in vertebrate animals is important for regulation of responses to stress, chiefly by release of adrenocorticotropic hormone (ACTH) from the pituitary, which in turn stimulates release of steroid glucocorticoids from the adrenal glands. In birds, the...

Showing 6349 to 6358 of 6358 entries