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Showing 13 to 24 of 408 entries
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Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine.

Biochemical Society transactions

Diotallevi M, Ayaz F, Nicol T, Crabtree MJ.
PMID: 34665229
Biochem Soc Trans. 2021 Nov 01;49(5):2189-2198. doi: 10.1042/BST20210269.

Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has been placed centrally in the governance of...

Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells.

Biochemical Society transactions

Atkin-Smith GK.
PMID: 33843978
Biochem Soc Trans. 2021 Apr 30;49(2):793-804. doi: 10.1042/BST20200696.

Although millions of cells in the human body will undergo programmed cell death each day, dying cells are rarely detected under homeostatic settings in vivo. The swift removal of dying cells is due to the rapid recruitment of phagocytes...

Molecular mechanisms of transcription factor mediated cell reprogramming: conversion of liver to pancreas.

Biochemical Society transactions

Wild SL, Tosh D.
PMID: 33666218
Biochem Soc Trans. 2021 Apr 30;49(2):579-590. doi: 10.1042/BST20200219.

Transdifferentiation is a type of cellular reprogramming involving the conversion of one differentiated cell type to another. This remarkable phenomenon holds enormous promise for the field of regenerative medicine. Over the last 20 years techniques used to reprogram cells...

Teaching versus learning.

Biochemical Society transactions

Patterson JA.
PMID: 8359502
Biochem Soc Trans. 1993 May;21(2):383-7. doi: 10.1042/bst0210383.

No abstract available.

Review of General Medical Council proposals on undergraduate medical education.

Biochemical Society transactions

Shaw DA.
PMID: 8359500
Biochem Soc Trans. 1993 May;21(2):377-9. doi: 10.1042/bst0210377.

No abstract available.

Pluripotency transcription factors at the focus: the phase separation paradigm in stem cells.

Biochemical Society transactions

Oses C, Stortz M, Verneri P, Guberman A, Levi V.
PMID: 34812855
Biochem Soc Trans. 2021 Dec 17;49(6):2871-2878. doi: 10.1042/BST20210856.

The transcription factors (TFs) OCT4, SOX2 and NANOG are key players of the gene regulatory network of pluripotent stem cells. Evidence accumulated in recent years shows that even small imbalances in the expression levels or relative concentrations of these...

Insights into neurodegeneration from electron microscopy studies.

Biochemical Society transactions

Crowther RA.
PMID: 34812894
Biochem Soc Trans. 2021 Dec 17;49(6):2777-2786. doi: 10.1042/BST20210719.

Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, pose an increasingly severe burden for individuals and society in an ageing population. The causes and mechanisms of the diseases are poorly understood and as yet there are no effective...

HTR6 and SSTR3 targeting to primary cilia.

Biochemical Society transactions

Barbeito P, Garcia-Gonzalo FR.
PMID: 33599752
Biochem Soc Trans. 2021 Feb 26;49(1):79-91. doi: 10.1042/BST20191005.

Primary cilia are hair-like projections of the cell membrane supported by an inner microtubule scaffold, the axoneme, which polymerizes out of a membrane-docked centriole at the ciliary base. By working as specialized signaling compartments, primary cilia provide an optimal...

Correction: Role of conformational change and K-path ligands in controlling cytochrome .

Biochemical Society transactions

Liu J, Hiser C, Ferguson-Miller S.
PMID: 29247047
Biochem Soc Trans. 2017 Dec 15;45(6):1345. doi: 10.1042/BST-2016-0138C_COR.

No abstract available.

Plant derived cyclic peptides.

Biochemical Society transactions

Daly NL, Wilson DT.
PMID: 34156400
Biochem Soc Trans. 2021 Jun 30;49(3):1279-1285. doi: 10.1042/BST20200881.

Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers for many years. Several gene sequences for...

The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation.

Biochemical Society transactions

Raposo AC, Casanova M, Gendrel AV, da Rocha ST.
PMID: 34882219
Biochem Soc Trans. 2021 Dec 17;49(6):2549-2560. doi: 10.1042/BST20210253.

X-inactive-specific transcript (Xist) is a long non-coding RNA (lncRNA) essential for X-chromosome inactivation (XCI) in female placental mammals. Thirty years after its discovery, it is still puzzling how this lncRNA triggers major structural and transcriptional changes leading to the...

Alpha-to-beta cell trans-differentiation for treatment of diabetes.

Biochemical Society transactions

Saleh M, Gittes GK, Prasadan K.
PMID: 34882233
Biochem Soc Trans. 2021 Dec 09; doi: 10.1042/BST20210244. Epub 2021 Dec 09.

Diabetes mellitus is a significant cause of morbidity and mortality in the United States and worldwide. According to the CDC, in 2017, ∼34.2 million of the American population had diabetes. Also, in 2017, diabetes was the seventh leading cause...

Showing 13 to 24 of 408 entries