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Showing 25 to 36 of 1876 entries
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Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang Y, Kuang X, Yin Y, Han N, Chang L, Wang H, Hou Y, Li H, Li Z, Liu Y, Hao Y, Wei Y, Wang X, Jia Z.
PMID: 34740097
Biomed Pharmacother. 2022 Jan;145:112367. doi: 10.1016/j.biopha.2021.112367. Epub 2021 Nov 02.

Cardiovascular comorbidities are pervasive in chronic obstructive pulmonary disease (COPD) and often result in serious adverse cardiovascular events. Tongxinluo (TXL) has been clinically verified to treat atherosclerosis (AS), improve lung function and alleviate dyspnoea. The present study aimed to...

Neutrophil accumulation within tissues: A damage x healing dichotomy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Oliveira-Costa KM, Menezes GB, Paula Neto HA.
PMID: 34781139
Biomed Pharmacother. 2022 Jan;145:112422. doi: 10.1016/j.biopha.2021.112422. Epub 2021 Nov 12.

The abundance of neutrophils in human circulation, their fast mobilization from blood to tissues, along with their alleged short life-span led to the image of neutrophils as a homogeneous cell type designed to fight infections and die in the...

Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Yin LJ, Bin Ahmad Kamar AKD, Fung GT, Liang CT, Avupati VR.
PMID: 34785416
Biomed Pharmacother. 2022 Jan;145:112406. doi: 10.1016/j.biopha.2021.112406. Epub 2021 Nov 13.

Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its well-known ability to demonstrate a broad range of biological activities. The possibility of structural diversification has contributed to the significance of rhodanine structure in effective...

Mechanism of Infantile Feire Kechuan Oral Solution against Mycoplasma pneumoniae infection of A549 cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wan R, Jia M, Dou H, Tu P, Shi D, Yuan Q, Xin D.
PMID: 34776306
Biomed Pharmacother. 2022 Jan;145:112366. doi: 10.1016/j.biopha.2021.112366. Epub 2021 Nov 11.

BACKGROUND: Mycoplasma pneumoniae is a leading cause of community-acquired respiratory infections. Infantile Feire Kechuan Oral Solution (IFKOS) is effective for treatment of M. pneumoniae infection. The aim of this study was to explore the potential mechanism of IFKOS against...

The impact of non-coding RNAs on normal stem cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ghafouri-Fard S, Moghadam MHB, Shoorei H, Bahroudi Z, Taheri M, Taheriazam A.
PMID: 34426251
Biomed Pharmacother. 2021 Oct;142:112050. doi: 10.1016/j.biopha.2021.112050. Epub 2021 Aug 19.

Self-renewal and differentiation into diverse cells are two main characteristics of stem cells. These cells have important roles in development and homeostasis of different tissues and are supposed to facilitate tissue regeneration. Function of stem cells is regulated by...

A concise review on the role of BDNF-AS in human disorders.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ghafouri-Fard S, Khoshbakht T, Taheri M, Ghanbari M.
PMID: 34426254
Biomed Pharmacother. 2021 Oct;142:112051. doi: 10.1016/j.biopha.2021.112051. Epub 2021 Aug 18.

Brain-derived neurotrophic factor-antisense (BDNF-AS) is a long non-coding RNA with tens of alternatively spliced variants being transcribed from 11p14 cytogenetic band. As a naturally occurring anti-sense, it regulates expression of BDNF, a factor which as essential roles in the...

Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Yang S, Xiao H, Cao L.
PMID: 34426258
Biomed Pharmacother. 2021 Oct;142:112074. doi: 10.1016/j.biopha.2021.112074. Epub 2021 Aug 20.

Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27,...

Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Tang ZY, Li Y, Tang YT, Ma XD, Tang ZY.
PMID: 34798468
Biomed Pharmacother. 2022 Jan;145:112397. doi: 10.1016/j.biopha.2021.112397. Epub 2021 Nov 16.

Oleanolic acid (OA, 3 β - hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic triterpenoid present in many plants. As a new framework for development of semi synthetic triterpenoids, OA is of great significance in the discovery of anticancer drugs. Some...

Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang R, Wang M, Liu B, Xu H, Ye J, Sun X, Sun G.
PMID: 34798472
Biomed Pharmacother. 2022 Jan;145:112432. doi: 10.1016/j.biopha.2021.112432. Epub 2021 Nov 17.

Calenduloside E (CE) is a saponin isolated from Aralia elata (Miq) Seem, which has anti-cardiovascular disease effects. This study aims to evaluate the anti-myocardial ischemia-reperfusion injury (MIRI) mechanisms of CE and regulation of BAG3 on calcium overload. We adopted...

Periplocin ameliorates mouse age-related meibomian gland dysfunction through up-regulation of Na/K-ATPase via SRC pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang H, Zou Z, Wan L, Xue J, Chen C, Yu B, Zhang Z, Yang L, Xie L.
PMID: 34883449
Biomed Pharmacother. 2021 Dec 06;146:112487. doi: 10.1016/j.biopha.2021.112487. Epub 2021 Dec 06.

Age-related meibomian gland dysfunction (MGD) is the main cause of evaporative dry eye disease in an aging population. Decreased meibocyte cell renewal and lipid synthesis are associated with age-related MGD. Here, we found an obvious decline of Ki67, ΔNp63,...

Clinical application and pharmacological mechanism of Wuling powder in the treatment of ascites: A systematic review and network pharmacological analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Mou Y, Wang X, Wang T, Wang Y, Wang H, Zhao H, Chen Q, Xia L, Zhang Y.
PMID: 34883450
Biomed Pharmacother. 2021 Dec 06;146:112506. doi: 10.1016/j.biopha.2021.112506. Epub 2021 Dec 06.

Ascites is one of the common complications in patients with decompensated liver cirrhosis and liver cancer. Wuling powder (WLP) is a classic prescription for the treatment of water retention caused by bladder gasification. It is also widely used in...

Therapeutic potential of CAR T cell in malignancies: A scoping review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Mehrabadi AZ, Ranjbar R, Farzanehpour M, Shahriary A, Dorostkar R, Hamidinejad MA, Ghaleh HEG.
PMID: 34894519
Biomed Pharmacother. 2021 Dec 08;146:112512. doi: 10.1016/j.biopha.2021.112512. Epub 2021 Dec 08.

Although tremendous advancements in cancer therapy over the last several years, cancer still is a complex illness to cure. Traditional cancer treatments, including chemotherapy, radiotherapy, and surgery, have a poor therapeutic effect, emphasizing the significance of employing innovative treatments...

Showing 25 to 36 of 1876 entries