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Showing 421 to 427 of 427 entries
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MiR-181a-5p facilitates proliferation, invasion, and glycolysis of breast cancer through NDRG2-mediated activation of PTEN/AKT pathway.

Bioengineered

Zhai Z, Mu T, Zhao L, Li Y, Zhu D, Pan Y.
PMID: 34951340
Bioengineered. 2022 Jan;13(1):83-95. doi: 10.1080/21655979.2021.2006974.

Dysregulation of microRNAs (miRNAs) is associated with the occurrence and development of breast cancer. In this research, we explored the involvement of miR-181a-5p in the progression of breast cancer and investigated potential molecular mechanisms. Firstly, the miR-181a-5p and N-myc...

Caveolin-1 Scaffolding Domain Peptide Regulates Colon Endothelial Cell Survival through JNK Pathway.

International journal of inflammation

Fang K, Kevil CG.
PMID: 35013693
Int J Inflam. 2020 Mar 06;2020:6150942. doi: 10.1155/2020/6150942. eCollection 2020.

It has been reported that pathological angiogenesis contributes to both experimental colitis and inflammatory bowel disease. Recently, we demonstrated that endothelial caveolin-1 plays a key role in the pathological angiogenesis of dextran sodium sulfate (DSS) colitis. However, the molecular...

TGF-β1/SMOC2/AKT and ERK axis regulates proliferation, migration, and fibroblast to myofibroblast transformation in lung fibroblast, contributing with the asthma progression.

Hereditas

Wang Y, Yang H, Su X, Cao A, Chen F, Chen P, Yan F, Hu H.
PMID: 34876240
Hereditas. 2021 Dec 08;158(1):47. doi: 10.1186/s41065-021-00213-w.

BACKGROUND: Asthma is a common chronic respiratory disease that influences 300 million people all over the world. However, the pathogenesis of asthma has not been fully elucidated. It has been reported that transforming growth factor-β (TGF-β) can activate myofibroblasts....

Metabolic Regulation of Hippocampal Neuronal Development and Its Inhibition After Irradiation.

Journal of neuropathology and experimental neurology

Li YQ, Wong CS.
PMID: 33706379
J Neuropathol Exp Neurol. 2021 Apr 16;80(5):467-475. doi: 10.1093/jnen/nlab014.

5'-Adenosine monophosphate-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, plays a role in cell fate determination. Whether AMPK regulates hippocampal neuronal development remains unclear. Hippocampal neurogenesis is abrogated after DNA damage. Here, we asked whether AMPK...

Distribution of Label-Retaining Cells and their Properties in the Newborn Vocal Fold Mucosa.

Journal of voice : official journal of the Voice Foundation

Sato K, Kurita T, Chitose SI, Sato F, Sato K, Umeno H.
PMID: 33865655
J Voice. 2021 Apr 14; doi: 10.1016/j.jvoice.2021.03.003. Epub 2021 Apr 14.

OBJECTIVES: There is growing evidence that the cells in the maculae flavae (MFe) are candidates for tissue stem cells of the vocal fold mucosa and the MFe are a stem cell niche. Distribution of label-retaining cells and their properties...

Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4.

Cerebral cortex (New York, N.Y. : 1991)

Yamazaki Y, Moizumi M, Nagai J, Hatashita Y, Cai T, Kolattukudy P, Inoue T, Goshima Y, Ohshima T.
PMID: 34297816
Cereb Cortex. 2021 Jul 23; doi: 10.1093/cercor/bhab228. Epub 2021 Jul 23.

The mammalian cerebral cortex is characterized by a 6-layer structure, and proper neuronal migration is critical for its formation. Cyclin-dependent kinase 5 (Cdk5) has been shown to be a critical kinase for neuronal migration. Several Cdk5 substrates have been...

Prenatal exposure to di(n-butyl) phthalate delays the spermatogenic cycle in rats: Investigation using a BrdU-injection method.

Reproductive toxicology (Elmsford, N.Y.)

Wakui S, Sato D, Okayama Y, Kansaku N, Muto T.
PMID: 35032615
Reprod Toxicol. 2022 Jan 12; doi: 10.1016/j.reprotox.2022.01.003. Epub 2022 Jan 12.

Di(n-butyl) phthalate (DBP) esters are plasticizers that are used to provide transparency and flexibility in household plastic products but can easily leach out to contaminate organisms and the environment. We investigated whether prenatal DBP exposure affects spermatogenesis in rats....

Showing 421 to 427 of 427 entries