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Showing 781 to 790 of 790 entries
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Significant co-expression of putative cancer stem cell markers, EpCAM and CD166, correlates with tumor stage and invasive behavior in colorectal cancer.

World journal of surgical oncology

Kalantari E, Taheri T, Fata S, Abolhasani M, Mehrazma M, Madjd Z, Asgari M.
PMID: 35016698
World J Surg Oncol. 2022 Jan 11;20(1):15. doi: 10.1186/s12957-021-02469-y.

BACKGROUND: The crucial oncogenic role of cancer stem cells (CSCs) in tumor maintenance, progression, drug resistance, and relapse has been clarified in different cancers, particularly in colorectal cancer (CRC). The current study was conducted to evaluate the co-expression pattern...

Identification of pivotal genes associated with the prognosis of gastric carcinoma through integrated analysis.

Bioscience reports

Ma Z, Xu J, Ru L, Zhu W.
PMID: 33754626
Biosci Rep. 2021 Apr 30;41(4). doi: 10.1042/BSR20203676.

PURPOSE: Detecting and diagnosing gastric cancer (GC) during its early period remains greatly difficult. Our analysis was performed to detect core genes correlated with GC and explore their prognostic values.METHODS: Microarray datasets from the Gene Expression Omnibus (GEO) (GSE54129)...

Feprazone Prevents Free Fatty Acid (FFA)-Induced Endothelial Inflammation by Mitigating the Activation of the TLR4/MyD88/NF-κB Pathway.

ACS omega

Song M, Meng L, Liu X, Yang Y.
PMID: 33644593
ACS Omega. 2021 Feb 09;6(7):4850-4856. doi: 10.1021/acsomega.0c05826. eCollection 2021 Feb 23.

Increased levels of free fatty acid (FFA)-induced endothelial dysfunction play an important role in the initiation and development of atherosclerosis. Feprazone is a nonsteroidal anti-inflammatory compound. However, the beneficial effects of feprazone on FFA-induced endothelial dysfunction have not been...

Thin films of functionalized carbon nanotubes support long-term maintenance and cardio-neuronal differentiation of canine induced pluripotent stem cells.

Nanomedicine : nanotechnology, biology, and medicine

Mondal T, Das K, Singh P, Natarajan M, Manna B, Ghosh A, Singh P, Saha SK, Dhama K, Dutt T, Bag S.
PMID: 34740869
Nanomedicine. 2021 Nov 03;40:102487. doi: 10.1016/j.nano.2021.102487. Epub 2021 Nov 03.

Induced pluripotent stem cells (iPSCs) are a promising cell source for regenerative medicine. However, their feeder-free maintenance in undifferentiated states remains challenging. In recent past extensive studies have been directed using pristine or functionalized carbon nanotube in tissue engineering....

Aberrant Claudin-6-Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α.

Molecular cancer research : MCR

Kojima M, Sugimoto K, Kobayashi M, Ichikawa-Tomikawa N, Kashiwagi K, Watanabe T, Soeda S, Fujimori K, Chiba H.
PMID: 33727343
Mol Cancer Res. 2021 Jul;19(7):1208-1220. doi: 10.1158/1541-7786.MCR-20-0835. Epub 2021 Mar 16.

Cell adhesion proteins not only maintain tissue integrity, but also possess signaling abilities to organize diverse cellular events in a variety of physiologic and pathologic processes; however, the underlying mechanism remains obscure. Among cell adhesion molecules, the claudin (CLDN)...

High-dose dexamethasone injection disordered metabolism and multiple protein kinases expression in the mouse kidney.

Bioscience reports

Zhang Z, Ran Y, Xu L, Pan Z, Xie Y.
PMID: 34735568
Biosci Rep. 2021 Nov 26;41(11). doi: 10.1042/BSR20211847.

Glucocorticoids (GCs) have been widely used in clinical treatment as anti-inflammatory, anti-shock and immunosuppressive medicines. However, the effect of excessive GCs on immune response and metabolism of kidney remains unclear. Here, we profiled the gene expression of kidney from...

Transcriptome analysis reveals key genes and pathways associated with egg production in Nandan-Yao domestic chicken.

Comparative biochemistry and physiology. Part D, Genomics & proteomics

Sun T, Xiao C, Deng J, Yang Z, Zou L, Du W, Li S, Huo X, Zeng L, Yang X.
PMID: 34509172
Comp Biochem Physiol Part D Genomics Proteomics. 2021 Dec;40:100889. doi: 10.1016/j.cbd.2021.100889. Epub 2021 Aug 20.

BACKGROUND: Egg production is a very important economic trait in chicken breeding, but its molecular mechanism is unclear until now. Nandan-Yao chicken (Gallus gallus domesticus) is a native breed in Guangxi province, China, which is famous for good meet...

Lianhuaqingwen capsule inhibits influenza-induced bacterial adhesion to respiratory epithelial cells through down-regulation of cell adhesion molecules.

Journal of ethnopharmacology

Du Q, Huang W, Zhao J, Zeng J, Zhang W, Huang X, Chen R, Jiang H, Xie Y, Wang Y, Zhong N, Wang X, Yang Z.
PMID: 33872750
J Ethnopharmacol. 2021 Nov 15;280:114128. doi: 10.1016/j.jep.2021.114128. Epub 2021 Apr 16.

ETHNOPHARMACOLOGICAL RELEVANCE: Influenza virus infection is widely believed to cause mild symptoms, but can lead to high mortality and severe disease complicated by secondary bacterial pneumonia. Traditional Chinese medicine (TCM) has been proposed as a promising agent to treat...

Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression.

The ocular surface

Swamynathan S, Campbell G, Tiwari A, Swamynathan SK.
PMID: 34923162
Ocul Surf. 2021 Dec 16;24:1-11. doi: 10.1016/j.jtos.2021.12.006. Epub 2021 Dec 16.

PURPOSE: Previously we demonstrated that the secreted Ly-6/uPAR related protein-1 (SLURP1), abundantly expressed in the corneal epithelium (CE) and secreted into the tear fluid, serves as an anti-inflammatory and anti-angiogenic molecule. Here we describe the Slurp1-null (Slurp1X-/-) mouse corneal...

Reduced frequency of perforin-positive CD8+ T cells in menstrual effluent of endometriosis patients.

Journal of reproductive immunology

Schmitz T, Hoffmann V, Olliges E, Bobinger A, Popovici R, Nößner E, Meissner K.
PMID: 34563756
J Reprod Immunol. 2021 Nov;148:103424. doi: 10.1016/j.jri.2021.103424. Epub 2021 Sep 20.

Endometriosis is a widespread disease and commonly reduces the life quality of those affected. Scientific literature indicates different underlying immunological changes. Frequently examined tissues are peripheral blood, endometrial tissue and peritoneal fluid. Yet, knowledge on immunological differences in menstrual...

Showing 781 to 790 of 790 entries