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Showing 25 to 36 of 143 entries
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Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain.

Molecular psychiatry

Yoon G, Lim YH, Jo D, Ryu J, Song J, Kim YK.
PMID: 34561612
Mol Psychiatry. 2021 Nov;26(11):6350-6364. doi: 10.1038/s41380-021-01303-x. Epub 2021 Sep 24.

Metabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting in cognitive deficits. Only a few studies explored the contribution of non-coding genes in these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing the brain cortices...

Augmented cell cycle protein expression and kinase activity in atherosclerotic rabbit vessels.

Experimental and clinical cardiology

Zettler ME, Merchant MA, Pierce GN.
PMID: 21264072
Exp Clin Cardiol. 2010;15(4):e139-44.

Cell proliferation within a primary atherosclerotic plaque is controversial. Identifying changes in cell cycle protein expression and the activities of their related kinases would provide valuable evidence of mitotic activity in the atherosclerotic lesion. Oxidized low-density lipoprotein has been...

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins.

Bioinformation

Rekha UV, Anita M, Jayamathi G, Sadhana K, Deepa S, Hussain S, Bhuvaneswari J, Ramya V, Selvaraj J, Naveenraj NS.
PMID: 32831516
Bioinformation. 2020 May 31;16(5):359-362. doi: 10.6026/97320630016359. eCollection 2020.

Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs,...

Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death.

Cell death discovery

Marlier Q, Jibassia F, Verteneuil S, Linden J, Kaldis P, Meijer L, Nguyen L, Vandenbosch R, Malgrange B.
PMID: 29581894
Cell Death Discov. 2018 Mar 16;4:43. doi: 10.1038/s41420-018-0044-7. eCollection 2018.

Cell cycle proteins are mainly expressed by dividing cells. However, it is well established that these molecules play additional non-canonical activities in several cell death contexts. Increasing evidence shows expression of cell cycle regulating proteins in post-mitotic cells, including...

MicroRNA-125b-1-3p mediates intervertebral disc degeneration in rats by targeting teashirt zinc finger homeobox 3.

Experimental and therapeutic medicine

Meng X, Zhu Y, Tao L, Zhao S, Qiu S.
PMID: 29456666
Exp Ther Med. 2018 Mar;15(3):2627-2633. doi: 10.3892/etm.2018.5715. Epub 2018 Jan 08.

The present study aimed to investigate the association between Teashirt zinc finger homeobox 3 (TSHZ3) and the nucleus pulposus (NP) of intervertebral discs in rats. TSHZ3 was identified from the differentially expressed micro (mi)RNAs in the expression profile of...

A potential role for the Hippo pathway protein, YAP, in controlling proliferation, cell cycle progression, and autophagy in BCPAP and KI thyroid papillary carcinoma cells.

American journal of translational research

Liu Z, Zeng W, Wang S, Zhao X, Guo Y, Yu P, Yin X, Liu C, Huang T.
PMID: 28804541
Am J Transl Res. 2017 Jul 15;9(7):3212-3223. eCollection 2017.

PURPOSE: The aims were two-fold: first, to examine the expression of Yes-activated protein (YAP), a key Hippo pathway regulator, in clinical thyroid papillary carcinoma samples and to correlate this with clinicopathological parameters; second, to explore the role of YAP...

MiR-663a Stimulates Proliferation and Suppresses Early Apoptosis of Human Spermatogonial Stem Cells by Targeting NFIX and Regulating Cell Cycle.

Molecular therapy. Nucleic acids

Zhou F, Yuan Q, Zhang W, Niu M, Fu H, Qiu Q, Mao G, Wang H, Wen L, Wang H, Lu M, Li Z, He Z.
PMID: 30195770
Mol Ther Nucleic Acids. 2018 Sep 07;12:319-336. doi: 10.1016/j.omtn.2018.05.015. Epub 2018 Jul 04.

Human spermatogonial stem cells (SSCs) could have significant applications in reproductive medicine and regenerative medicine because of their great plasticity. The fate determinations of human SSCs are mediated by epigenetic factors. However, nothing is known about the regulation of...

Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies.

Oncology letters

Vranic S, Gatalica Z, Wang ZY.
PMID: 22121396
Oncol Lett. 2011 Nov;2(6):1131-1137. doi: 10.3892/ol.2011.375.

Apocrine carcinoma of the breast has recently been refined through gene expression profiling. Due to various pathological studies, we compared the results with the MDA-MB-453 breast cancer cell line, a proposed model for apocrine breast carcinoma. The MDA-MB-453 cell...

Oncogene-induced mitotic stress: p53 and pRb get mad too.

Cancer cell

Malumbres M.
PMID: 21665141
Cancer Cell. 2011 Jun 14;19(6):691-2. doi: 10.1016/j.ccr.2011.05.023.

Oncogenic signaling frequently results in unscheduled overexpression of cell cycle proteins and replicative stress. In this issue of Cancer Cell, Schvartzman et al. show that inactivation of p53 or pRb induces Mad2, and the overexpression of this mitotic checkpoint...

Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma.

World journal of hepatology

Bassiouny AE, Nosseir MM, Zoheiry MK, Ameen NA, Abdel-Hadi AM, Ibrahim IM, Zada S, El-Deen AH, El-Bassiouni NE.
PMID: 21160954
World J Hepatol. 2010 Jan 27;2(1):32-41. doi: 10.4254/wjh.v2.i1.32.

AIM: To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties.METHODS: Subjects of the current study included 50 cases of...

Molecular mechanisms of oestrogen action on growth of human breast cancer cells in culture.

Hormone molecular biology and clinical investigation

Darbre PD.
PMID: 25961353
Horm Mol Biol Clin Investig. 2012 Apr 01;9(1):65-85. doi: 10.1515/hmbci-2011-0003.

Growth responses to oestrogen can be reproducibly obtained using a selection of oestrogen-receptor-containing human breast cancer cell lines, and molecular mechanisms have been shown to include modulation to growth factor/receptor/signalling pathways, cell-cycle proteins, apoptosis, differentiation, adhesion, motility and migration....

Cycle on Wheels: Is APP Key to the AppBp1 Pathway?.

Austin Alzheimer's and Parkinson's disease

Chen Y, Neve R, Zheng H, Griffin W, Barger S, Mrak R.
PMID: 25568892
Austin Alzheimers Parkinsons Dis. 2014;1(2).

Alzheimer's disease (AD) is the gradual loss of the cognitive function due to neuronal death. Currently no therapy is available to slow down, reverse or prevent the disease. Here we analyze the existing data in literature and hypothesize that...

Showing 25 to 36 of 143 entries