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Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinesterases for the treatment of Alzheimer's disease.

Iranian journal of pharmaceutical research : IJPR

Abbasi MA, Saeed A, Aziz-Ur-Rehman, Mohmmed Khan K, Ashraf M, Ejaz SA.
PMID: 24734059
Iran J Pharm Res. 2014;13(1):87-94.

The present study reports the synthesis of a series N-substituted derivatives of brominated 2-phenitidine. First, the reaction of 2-phenitidine (1) with benzenesulfonyl chloride (2) in aqueous media yielded N-(2-ethoxyphenyl) benzenesulfonamide (3), which was then subjected to bromination with bromine...

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Abbasi MA, Saeed A, Aziz-Ur-Rehman, et al. Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinesterases for the treatment of Alzheimer's disease. Iran J Pharm Res. 2014;13(1):87-94
Abbasi, M. A., Saeed, A., Aziz-Ur-Rehman, Mohmmed Khan, K., Ashraf, M., & Ejaz, S. A. (2014). Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinesterases for the treatment of Alzheimer's disease. Iranian journal of pharmaceutical research : IJPR, 13(1), 87-94.
Abbasi, Muhammad Athar, et al. "Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinesterases for the treatment of Alzheimer's disease." Iranian journal of pharmaceutical research : IJPR vol. 13,1 (2014): 87-94.
Abbasi MA, Saeed A, Aziz-Ur-Rehman, Mohmmed Khan K, Ashraf M, Ejaz SA. Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinesterases for the treatment of Alzheimer's disease. Iran J Pharm Res. 2014;13(1):87-94. PMID: 24734059; PMCID: PMC3985256.
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Corrigendum to "A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives" [Bioorg. Med. Chem. Lett. 28 (14) (2018) 2481-2484].

Bioorganic & medicinal chemistry letters

Derabli C, Boualia I, Abdelwahab AB, Boulcina R, Bensouici C, Kirsch G, Debache A.
PMID: 30119958
Bioorg Med Chem Lett. 2018 Oct 01;28(18):3129. doi: 10.1016/j.bmcl.2018.08.008. Epub 2018 Aug 14.

No abstract available.

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Derabli C, Boualia I, Abdelwahab AB, et al. Corrigendum to "A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives" [Bioorg. Med. Chem. Lett. 28 (14) (2018) 2481-2484]. Bioorg Med Chem Lett. 2018;28(18):3129doi: 10.1016/j.bmcl.2018.08.008.
Derabli, C., Boualia, I., Abdelwahab, A. B., Boulcina, R., Bensouici, C., Kirsch, G., & Debache, A. (2018). Corrigendum to "A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives" [Bioorg. Med. Chem. Lett. 28 (14) (2018) 2481-2484]. Bioorganic & medicinal chemistry letters, 28(18), 3129. https://doi.org/10.1016/j.bmcl.2018.08.008
Derabli, Chamseddine, et al. "Corrigendum to "A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives" [Bioorg. Med. Chem. Lett. 28 (14) (2018) 2481-2484]." Bioorganic & medicinal chemistry letters vol. 28,18 (2018): 3129. doi: https://doi.org/10.1016/j.bmcl.2018.08.008
Derabli C, Boualia I, Abdelwahab AB, Boulcina R, Bensouici C, Kirsch G, Debache A. Corrigendum to "A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives" [Bioorg. Med. Chem. Lett. 28 (14) (2018) 2481-2484]. Bioorg Med Chem Lett. 2018 Oct 01;28(18):3129. doi: 10.1016/j.bmcl.2018.08.008. Epub 2018 Aug 14. PMID: 30119958.
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Anticholinesterase potential of flavonols from paper mulberry (Broussonetia papyrifera) and their kinetic studies.

Food chemistry

Ryu HW, Curtis-Long MJ, Jung S, Jeong IY, Kim DS, Kang KY, Park KH.
PMID: 29243607
Food Chem. 2012 Jun 01;132(3):1244-1250. doi: 10.1016/j.foodchem.2011.11.093. Epub 2011 Nov 25.

It is necessary to develop food additives to help treat chronic disorders like neurodegenerative diseases from medicinal plants. Ethanol extracts of paper mulberry were found to display significant inhibition against cholinesterases, enzymes that are strongly linked with Alzheimer's disease...

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Ryu HW, Curtis-Long MJ, Jung S, et al. Anticholinesterase potential of flavonols from paper mulberry (Broussonetia papyrifera) and their kinetic studies. Food Chem. 2011;132(3):1244-1250doi: 10.1016/j.foodchem.2011.11.093.
Ryu, H. W., Curtis-Long, M. J., Jung, S., Jeong, I. Y., Kim, D. S., Kang, K. Y., & Park, K. H. (2012). Anticholinesterase potential of flavonols from paper mulberry (Broussonetia papyrifera) and their kinetic studies. Food chemistry, 132(3), 1244-1250. https://doi.org/10.1016/j.foodchem.2011.11.093
Ryu, Hyung Won, et al. "Anticholinesterase potential of flavonols from paper mulberry (Broussonetia papyrifera) and their kinetic studies." Food chemistry vol. 132,3 (2012): 1244-1250. doi: https://doi.org/10.1016/j.foodchem.2011.11.093
Ryu HW, Curtis-Long MJ, Jung S, Jeong IY, Kim DS, Kang KY, Park KH. Anticholinesterase potential of flavonols from paper mulberry (Broussonetia papyrifera) and their kinetic studies. Food Chem. 2012 Jun 01;132(3):1244-1250. doi: 10.1016/j.foodchem.2011.11.093. Epub 2011 Nov 25. PMID: 29243607.
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Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication.

Asian Pacific journal of tropical medicine

Abdel-Salam OME, Youness ER, Mohammed NA, Yassen NN, Khadrawy YA, El-Toukhy SE, Sleem AA.
PMID: 28942826
Asian Pac J Trop Med. 2017 Aug;10(8):773-786. doi: 10.1016/j.apjtm.2017.07.018. Epub 2017 Aug 24.

OBJECTIVE: To investigate the effect of NMETHODS: Malathion (150 mg/kg) was given intraperitoneally (i.p.) along with l-NAME or 7-NI (10 or 20 mg/kg, i.p.) and rats were euthanized 4 h later. The lipid peroxidation product malondialdehyde (MDA), nitric oxide...

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Abdel-Salam OME, Youness ER, Mohammed NA, et al. Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication. Asian Pac J Trop Med. 2017;10(8):773-786doi: 10.1016/j.apjtm.2017.07.018.
Abdel-Salam, O. M. E., Youness, E. R., Mohammed, N. A., Yassen, N. N., Khadrawy, Y. A., El-Toukhy, S. E., & Sleem, A. A. (2017). Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication. Asian Pacific journal of tropical medicine, 10(8), 773-786. https://doi.org/10.1016/j.apjtm.2017.07.018
Abdel-Salam, Omar M E, et al. "Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication." Asian Pacific journal of tropical medicine vol. 10,8 (2017): 773-786. doi: https://doi.org/10.1016/j.apjtm.2017.07.018
Abdel-Salam OME, Youness ER, Mohammed NA, Yassen NN, Khadrawy YA, El-Toukhy SE, Sleem AA. Nitric oxide synthase inhibitors protect against brain and liver damage caused by acute malathion intoxication. Asian Pac J Trop Med. 2017 Aug;10(8):773-786. doi: 10.1016/j.apjtm.2017.07.018. Epub 2017 Aug 24. PMID: 28942826.
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Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders.

Frontiers in aging neuroscience

Ayaz M, Sadiq A, Junaid M, Ullah F, Ovais M, Ullah I, Ahmed J, Shahid M.
PMID: 31293414
Front Aging Neurosci. 2019 Jun 26;11:155. doi: 10.3389/fnagi.2019.00155. eCollection 2019.

Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improve cognitive capabilities, inhibit or delay the senescence process and related neurodegenerative disorders including Alzheimer's disease (AD). The flavonoids rich foods such as green tea, cocoa,...

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Ayaz M, Sadiq A, Junaid M, et al. Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders. Front Aging Neurosci. 2019;11:155doi: 10.3389/fnagi.2019.00155.
Ayaz, M., Sadiq, A., Junaid, M., Ullah, F., Ovais, M., Ullah, I., Ahmed, J., & Shahid, M. (2019). Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders. Frontiers in aging neuroscience, 11155. https://doi.org/10.3389/fnagi.2019.00155
Ayaz, Muhammad, et al. "Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders." Frontiers in aging neuroscience vol. 11 (2019): 155. doi: https://doi.org/10.3389/fnagi.2019.00155
Ayaz M, Sadiq A, Junaid M, Ullah F, Ovais M, Ullah I, Ahmed J, Shahid M. Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders. Front Aging Neurosci. 2019 Jun 26;11:155. doi: 10.3389/fnagi.2019.00155. eCollection 2019. PMID: 31293414; PMCID: PMC6606780.
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2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases.

Angewandte Chemie (International ed. in English)

Peng L, Nachon F, Wirz J, Goeldner M.
PMID: 29711614
Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2691-2693. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2691::AID-ANIE2691>3.0.CO;2-7.

As heavy-atom analogues of caged cholinergic ligands, the arsonium compounds 1-3 were synthesized for potential time-resolved crystallographic studies on cholinesterases. Compounds 1 and 3 possess the desired properties for dynamic studies on the catalytic mechanism of cholinesterases: structural similarity...

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Peng L, Nachon F, Wirz J, et al. 2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases. Angew Chem Int Ed Engl. 1998;37(19):2691-2693doi: 10.1002/(SICI)1521-3773(19981016)37:19<2691::AID-ANIE2691>3.0.CO;2-7.
Peng, L., Nachon, F., Wirz, J., & Goeldner, M. (1998). 2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases. Angewandte Chemie (International ed. in English), 37(19), 2691-2693. https://doi.org/10.1002/(SICI)1521-3773(19981016)37:19<2691::AID-ANIE2691>3.0.CO;2-7
Peng, Ling, et al. "2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases." Angewandte Chemie (International ed. in English) vol. 37,19 (1998): 2691-2693. doi: https://doi.org/10.1002/(SICI)1521-3773(19981016)37:19<2691::AID-ANIE2691>3.0.CO;2-7
Peng L, Nachon F, Wirz J, Goeldner M. 2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases. Angew Chem Int Ed Engl. 1998 Oct 16;37(19):2691-2693. doi: 10.1002/(SICI)1521-3773(19981016)37:19<2691::AID-ANIE2691>3.0.CO;2-7. PMID: 29711614.
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Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase.

Scientific reports

Čadež T, Kolić D, Šinko G, Kovarik Z.
PMID: 34728713
Sci Rep. 2021 Nov 02;11(1):21486. doi: 10.1038/s41598-021-00953-9.

Toxicity of organophosphorus compounds (OPs) remains a major public health concern due to their widespread use as pesticides and the existence of nerve agents. Their common mechanism of action involves inhibition of enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which...

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Čadež T, Kolić D, Šinko G, et al. Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase. Sci Rep. 2021;11(1):21486doi: 10.1038/s41598-021-00953-9.
Čadež, T., Kolić, D., Šinko, G., & Kovarik, Z. (2021). Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase. Scientific reports, 11(1), 21486. https://doi.org/10.1038/s41598-021-00953-9
Čadež, Tena, et al. "Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase." Scientific reports vol. 11,1 (2021): 21486. doi: https://doi.org/10.1038/s41598-021-00953-9
Čadež T, Kolić D, Šinko G, Kovarik Z. Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase. Sci Rep. 2021 Nov 02;11(1):21486. doi: 10.1038/s41598-021-00953-9. PMID: 34728713; PMCID: PMC8563940.
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Current therapeutic options for Alzheimer's disease.

Current genomics

Lleó A.
PMID: 19415128
Curr Genomics. 2007 Dec;8(8):550-8. doi: 10.2174/138920207783769549.

Alzheimer's disease (AD) is the most common neurodegenerative disease in the developed world. The increasing life expectancy in the last years has led to an increase in the prevalence of this age-related condition and has posed an important medical...

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Lleó A. Current therapeutic options for Alzheimer's disease. Curr Genomics. 2007;8(8):550-8doi: 10.2174/138920207783769549.
Lleó, A. (2007). Current therapeutic options for Alzheimer's disease. Current genomics, 8(8), 550-8. https://doi.org/10.2174/138920207783769549
Lleó, Alberto. "Current therapeutic options for Alzheimer's disease." Current genomics vol. 8,8 (2007): 550-8. doi: https://doi.org/10.2174/138920207783769549
Lleó A. Current therapeutic options for Alzheimer's disease. Curr Genomics. 2007 Dec;8(8):550-8. doi: 10.2174/138920207783769549. PMID: 19415128; PMCID: PMC2647161.
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A Rare Case of Suicide by Ingestion of Phorate: A Case Report and a Review of the Literature.

Healthcare (Basel, Switzerland)

Montana A, Rapisarda V, Esposito M, Amico F, Cocimano G, Nunno ND, Ledda C, Salerno M.
PMID: 33572719
Healthcare (Basel). 2021 Jan 29;9(2). doi: 10.3390/healthcare9020131.

Phorate is a systemic organophosphorus pesticide (OP) that acts by inhibiting cholinesterases. Recent studies have reported that long-term low/moderate exposure to OP could be correlated with impaired cardiovascular and pulmonary function and other neurological effects. A 70-year-old farmer died...

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Montana A, Rapisarda V, Esposito M, et al. A Rare Case of Suicide by Ingestion of Phorate: A Case Report and a Review of the Literature. Healthcare (Basel). 2021;9(2)doi: 10.3390/healthcare9020131.
Montana, A., Rapisarda, V., Esposito, M., Amico, F., Cocimano, G., Nunno, N. D., Ledda, C., & Salerno, M. (2021). A Rare Case of Suicide by Ingestion of Phorate: A Case Report and a Review of the Literature. Healthcare (Basel, Switzerland), 9(2), . https://doi.org/10.3390/healthcare9020131
Montana, Angelo, et al. "A Rare Case of Suicide by Ingestion of Phorate: A Case Report and a Review of the Literature." Healthcare (Basel, Switzerland) vol. 9,2 (2021). doi: https://doi.org/10.3390/healthcare9020131
Montana A, Rapisarda V, Esposito M, Amico F, Cocimano G, Nunno ND, Ledda C, Salerno M. A Rare Case of Suicide by Ingestion of Phorate: A Case Report and a Review of the Literature. Healthcare (Basel). 2021 Jan 29;9(2). doi: 10.3390/healthcare9020131. PMID: 33572719; PMCID: PMC7912370.
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Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies.

International journal of biological macromolecules

Nadeem MS, Khan JA, Rashid U.
PMID: 34687762
Int J Biol Macromol. 2021 Dec 15;193:19-26. doi: 10.1016/j.ijbiomac.2021.10.102. Epub 2021 Oct 20.

For the potential therapy of Alzheimer's disease (AD), cholinesterases (ChE) and monoamine oxidase (MAO) are key enzymes that regulate the level of acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) and monoamines. The aim of current research is the synthesis of multi-target compounds that...

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Nadeem MS, Khan JA, Rashid U. Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies. Int J Biol Macromol. 2021;193:19-26doi: 10.1016/j.ijbiomac.2021.10.102.
Nadeem, M. S., Khan, J. A., & Rashid, U. (2021). Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies. International journal of biological macromolecules, 19319-26. https://doi.org/10.1016/j.ijbiomac.2021.10.102
Nadeem, Muhammad Shahid, et al. "Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies." International journal of biological macromolecules vol. 193 (2021): 19-26. doi: https://doi.org/10.1016/j.ijbiomac.2021.10.102
Nadeem MS, Khan JA, Rashid U. Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies. Int J Biol Macromol. 2021 Dec 15;193:19-26. doi: 10.1016/j.ijbiomac.2021.10.102. Epub 2021 Oct 20. PMID: 34687762.
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Kinetics and computational analysis of cholinesterase inhibition by REVERC3, a bisdemethoxycurcumin-rich .

SAGE open medicine

Hv S, Raj A, K G, S C, K S.
PMID: 33282298
SAGE Open Med. 2020 Nov 23;8:2050312120973499. doi: 10.1177/2050312120973499. eCollection 2020.

No abstract available.

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Hv S, Raj A, K G, et al. Kinetics and computational analysis of cholinesterase inhibition by REVERC3, a bisdemethoxycurcumin-rich . SAGE Open Med. 2020;8:2050312120973499doi: 10.1177/2050312120973499.
Hv, S., Raj, A., K, G., S, C., & K, S. (2020). Kinetics and computational analysis of cholinesterase inhibition by REVERC3, a bisdemethoxycurcumin-rich . SAGE open medicine, 82050312120973499. https://doi.org/10.1177/2050312120973499
Hv, Sudeep, et al. "Kinetics and computational analysis of cholinesterase inhibition by REVERC3, a bisdemethoxycurcumin-rich ." SAGE open medicine vol. 8 (2020): 2050312120973499. doi: https://doi.org/10.1177/2050312120973499
Hv S, Raj A, K G, S C, K S. Kinetics and computational analysis of cholinesterase inhibition by REVERC3, a bisdemethoxycurcumin-rich . SAGE Open Med. 2020 Nov 23;8:2050312120973499. doi: 10.1177/2050312120973499. eCollection 2020. PMID: 33282298; PMCID: PMC7686599.
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New chalcone derivative, ethyl 2-(4-(3-(benzo[.

Journal of biomolecular structure & dynamics

Çelik F, Süleymanoğlu N, Ustabaş R, Türkan F, Güler Hİ, Ünver Y, Kahriman N.
PMID: 34445923
J Biomol Struct Dyn. 2021 Aug 26;1-8. doi: 10.1080/07391102.2021.1969287. Epub 2021 Aug 26.

Chalcone derivative, ethyl 2-(4-(3-(benzo[

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Çelik F, Süleymanoğlu N, Ustabaş R, et al. New chalcone derivative, ethyl 2-(4-(3-(benzo[. J Biomol Struct Dyn. 2021;1-8doi: 10.1080/07391102.2021.1969287.
Çelik, F., Süleymanoğlu, N., Ustabaş, R., Türkan, F., Güler, H. �. �., Ünver, Y., & Kahriman, N. (2021). New chalcone derivative, ethyl 2-(4-(3-(benzo[. Journal of biomolecular structure & dynamics, 1-8. https://doi.org/10.1080/07391102.2021.1969287
Çelik, Fatih, et al. "New chalcone derivative, ethyl 2-(4-(3-(benzo[." Journal of biomolecular structure & dynamics vol. (2021): 1-8. doi: https://doi.org/10.1080/07391102.2021.1969287
Çelik F, Süleymanoğlu N, Ustabaş R, Türkan F, Güler Hİ, Ünver Y, Kahriman N. New chalcone derivative, ethyl 2-(4-(3-(benzo[. J Biomol Struct Dyn. 2021 Aug 26;1-8. doi: 10.1080/07391102.2021.1969287. Epub 2021 Aug 26. PMID: 34445923.
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