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Showing 1021 to 1031 of 1031 entries
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Intracellular Pathways of Holothuroid Oocyte Maturation Induced by the Thioredoxin Trx-REES.

Antioxidants (Basel, Switzerland)

Delroisse J, Léonet A, Alexandre H, Eeckhaut I.
PMID: 34439448
Antioxidants (Basel). 2021 Jul 27;10(8). doi: 10.3390/antiox10081201.

In holothuroids, oocyte maturation is stopped in ovaries at the prophase I stage of meiosis. In natural conditions, the blockage is removed during the spawning by an unknown mechanism. When oocytes are isolated by dissection, the meiotic release can...

Proteome-wide mapping of short-lived proteins in human cells.

Molecular cell

Li J, Cai Z, Vaites LP, Shen N, Mitchell DC, Huttlin EL, Paulo JA, Harry BL, Gygi SP.
PMID: 34626566
Mol Cell. 2021 Nov 18;81(22):4722-4735.e5. doi: 10.1016/j.molcel.2021.09.015. Epub 2021 Oct 08.

Rapid protein degradation enables cells to quickly modulate protein abundance. Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A focused map of short-lived proteins remains understudied. Cycloheximide, a translational inhibitor, is widely used in targeted studies to...

ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling.

Journal of experimental & clinical cancer research : CR

Wu Q, Zhou X, Li P, Ding M, You S, Xu Z, Ye J, Chen X, Tan M, Wang J, Wang W, Qiu J.
PMID: 33962660
J Exp Clin Cancer Res. 2021 May 07;40(1):158. doi: 10.1186/s13046-021-01935-5.

BACKGROUND: Regulator of cullins 1 (ROC1) is an important catalytic subunit of cullin-RING E3 ligase. Nuclear factor-kappa B (NF-κB) signaling is closely related to tumor invasion and metastasis. Earlier, we reported that ROC1 was associated with a poor prognosis...

Suppressive role of E3 ubiquitin ligase FBW7 in type I diabetes in non-obese diabetic mice through mediation of ubiquitination of EZH2.

Cell death discovery

Guo Y, Li J, Fan S, Hu Q.
PMID: 34802056
Cell Death Discov. 2021 Nov 20;7(1):361. doi: 10.1038/s41420-021-00605-x.

The current study tried to uncover the molecular mechanism of E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (FBW7) in a heritable autoimmune disease, type I diabetes (T1D). After streptozotocin-induced T1D model establishment in non-obese diabetic (NOD) mouse,...

The BRCA2 missense mutation K2497R suppressed self-degradation and increased ATP production and cell proliferation.

Biochemical and biophysical research communications

Enkhbat G, Nakanishi A, Miki Y.
PMID: 34968781
Biochem Biophys Res Commun. 2021 Dec 23;590:27-33. doi: 10.1016/j.bbrc.2021.12.073. Epub 2021 Dec 23.

Breast cancer susceptibility gene 2 (BRCA2) mediates genome maintenance during the S phase of the cell cycle, with important roles in replication stress, centrosome replication, and cytokinesis. In this study, we showed that a small heat shock protein, HSP27,...

Activation of bovine oocytes by protein synthesis inhibitors: new findings on the role of MPF/MAPKs†.

Biology of reproduction

Valencia C, Pérez FA, Matus C, Felmer R, Arias ME.
PMID: 33550378
Biol Reprod. 2021 May 07;104(5):1126-1138. doi: 10.1093/biolre/ioab019.

The present study evaluated the mechanism by which protein synthesis inhibitors activate bovine oocytes. The aim was to analyze the dynamics of MPF and MAPKs. MII oocytes were activated with ionomycin (Io), ionomycin+anisomycin (ANY) and ionomycin+cycloheximide (CHX) and by...

Nanostructured lipid carriers of isradipine for effective management of hypertension and isoproterenol induced myocardial infarction.

Drug delivery and translational research

Alam T, Ansari MA, Baboota S, Ali J.
PMID: 33782898
Drug Deliv Transl Res. 2021 Mar 29; doi: 10.1007/s13346-021-00958-x. Epub 2021 Mar 29.

The objective of the present paper is to formulate nanostructured lipid carriers (NLCs) of a calcium channel blocker, isradipine, to enhance its oral bioavailability and prolong its antihypertensive effect apart from evaluating efficacy of the formulation in isoproterenol induced...

The BRCA2 missense mutation K2497R suppressed self-degradation and increased ATP production and cell proliferation.

Biochemical and biophysical research communications

Enkhbat G, Nakanishi A, Miki Y.
PMID: 34968781
Biochem Biophys Res Commun. 2022 Jan 29;590:27-33. doi: 10.1016/j.bbrc.2021.12.073. Epub 2021 Dec 23.

Breast cancer susceptibility gene 2 (BRCA2) mediates genome maintenance during the S phase of the cell cycle, with important roles in replication stress, centrosome replication, and cytokinesis. In this study, we showed that a small heat shock protein, HSP27,...

Proteome-wide mapping of short-lived proteins in human cells.

Molecular cell

Li J, Cai Z, Vaites LP, Shen N, Mitchell DC, Huttlin EL, Paulo JA, Harry BL, Gygi SP.
PMID: 34626566
Mol Cell. 2021 Nov 18;81(22):4722-4735.e5. doi: 10.1016/j.molcel.2021.09.015. Epub 2021 Oct 08.

Rapid protein degradation enables cells to quickly modulate protein abundance. Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A focused map of short-lived proteins remains understudied. Cycloheximide, a translational inhibitor, is widely used in targeted studies to...

Candidiasis in Birds (Galliformes, Anseriformes, Psittaciformes, Passeriformes, and Columbiformes): A Focus on Antifungal Susceptibility Pattern of Candida albicans and Non-albicans Isolates in Avian Clinical Specimens.

Topics in companion animal medicine

Talazadeh F, Ghorbanpoor M, Shahriyari A.
PMID: 34700027
Top Companion Anim Med. 2021 Oct 23;46:100598. doi: 10.1016/j.tcam.2021.100598. Epub 2021 Oct 23.

Candidiasis is a fungal infection caused by Candida species which has been reported in most domestic and wild birds and mammals. In this study, 196 samples from different species of birds with suspected symptoms of candidiasis were examined. Pharyngeal...

MFS1, a Pleiotropic Transporter in Dermatophytes That Plays a Key Role in Their Intrinsic Resistance to Chloramphenicol and Fluconazole.

Journal of fungi (Basel, Switzerland)

Yamada T, Yaguchi T, Salamin K, Guenova E, Feuermann M, Monod M.
PMID: 34356921
J Fungi (Basel). 2021 Jul 07;7(7). doi: 10.3390/jof7070542.

A recently identified

Showing 1021 to 1031 of 1031 entries