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Showing 13 to 24 of 69 entries
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Efficacy and safety of cyclooxygenase 2 inhibitors for desmoid tumor management: a systematic review.

Nagoya journal of medical science

Emori M, Matsumoto Y, Murahashi Y, Yoshida M, Nishida Y.
PMID: 34916712
Nagoya J Med Sci. 2021 Nov;83(4):673-681. doi: 10.18999/nagjms.83.4.673.

The efficacy and safety of cyclooxygenase 2 (COX2) inhibitors for the treatment of desmoid-type fibromatosis (DF) are unclear. Therefore, we systematically reviewed related literature to assess the efficacy and safety of COX2 inhibitors for DF treatment. We searched pertinent...

A systematic review of the evidence supporting post-operative antithrombotic use following cardiopulmonary bypass in children with CHD.

Cardiology in the young

Thompson EJ, Foote HP, Li JS, Rotta AT, Goldenberg NA, Hornik CP.
PMID: 34986908
Cardiol Young. 2022 Jan 06;1-11. doi: 10.1017/S1047951121005205. Epub 2022 Jan 06.

OBJECTIVES: To determine the optimal antithrombotic agent choice, timing of initiation, dosing and duration of therapy for paediatric patients undergoing cardiac surgery with cardiopulmonary bypass.METHODS: We used PubMed and EMBASE to systematically review the existing literature of clinical trials...

Reducing prostaglandin E2 production to raise cancer immunogenicity.

Oncoimmunology

Zelenay S, Reis e Sousa C.
PMID: 27467936
Oncoimmunology. 2016 Jan 04;5(5):e1123370. doi: 10.1080/2162402X.2015.1123370. eCollection 2016 May.

Cyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive...

Rectal Acetaminophen Improves Shunt Volume and Reduces Patent Ductus Arteriosus Ligation in Extremely Preterm Infants.

American journal of perinatology

Castaldo MP, Neary E, Bischoff AR, Weisz DE, Jain A, Giesinger RE, McNamara PJ.
PMID: 34583409
Am J Perinatol. 2021 Sep 28; doi: 10.1055/s-0041-1735214. Epub 2021 Sep 28.

OBJECTIVE:  An alternative therapy for preterm infants with a hemodynamically significant patent ductus arteriosus (hsPDA) is needed when cyclooxygenase inhibitors fail or where treatment is contraindicated due to coexisting renal failure, necrotizing enterocolitis, and/or intestinal perforation. No studies have...

Do cyclooxygenase inhibitors increase risk of cardiovascular thrombotic events?.

Canadian family physician Medecin de famille canadien

Kvern B.
PMID: 12371303
Can Fam Physician. 2002 Sep;48:1449-51.

No abstract available.

Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases.

Case reports in dermatology

Garofalo V, Ventura A, Mazzilli S, Diluvio L, Bianchi L, Toti L, Tisone G, Milani M, Campione E.
PMID: 29282394
Case Rep Dermatol. 2017 Oct 20;9(3):211-216. doi: 10.1159/000481770. eCollection 2017.

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects...

Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents.

MedChemComm

Inceler N, Ozkan Y, Turan NN, Kahraman DC, Cetin-Atalay R, Baytas SN.
PMID: 30108969
Medchemcomm. 2018 Apr 06;9(5):795-811. doi: 10.1039/c8md00022k. eCollection 2018 May 01.

With the aim of achieving new compounds possessing both anti-inflammatory and antiplatelet activities, we synthesized (

Oral medications regarding their safety and efficacy in the management of patent ductus arteriosus.

World journal of clinical pediatrics

Oncel MY, Erdeve O.
PMID: 26862505
World J Clin Pediatr. 2016 Feb 08;5(1):75-81. doi: 10.5409/wjcp.v5.i1.75. eCollection 2016 Feb 08.

Patent ductus arteriosus (PDA) is a common clinical condition in preterm infants which is inversely related to birth weight and gestational age. Cyclooxygenase inhibitors such as indomethacin and ibuprofen which block the prostaglandin conversion from arachidonic acid are the...

Renal effects of prostaglandins and cyclooxygenase-2 inhibitors.

Electrolyte & blood pressure : E & BP

Kim GH.
PMID: 24459520
Electrolyte Blood Press. 2008 Jun;6(1):35-41. doi: 10.5049/EBP.2008.6.1.35. Epub 2008 Jun 30.

Prostaglandins (PGs) with best-defined renal functions are PGE2 and prostacyclin (PGI2). These vasodilatory PGs increase renal blood flow and glomerular filtration rate under conditions associated with decreased actual or effective circulating volume, resulting in greater tubular flow and secretion...

Pharmacology of nonsteroidal antiinflammatory drugs and opioids.

Seminars in interventional radiology

Slater D, Kunnathil S, McBride J, Koppala R.
PMID: 22550382
Semin Intervent Radiol. 2010 Dec;27(4):400-11. doi: 10.1055/s-0030-1267855.

Chronic pain affects up to 50 million Americans every day. Traditional treatment has included acetaminophen, nonsteroidal antiinflammatory drugs (NSAIDs), or opioids. The combination of NSAIDs and opioids can provide effective treatment for up to 90% of patients with chronic...

Evaluation of cyclooxygenase-1 and cyclooxygenase-2 expression and the effect of cyclooxygenase inhibitors in canine prostatic carcinoma.

Veterinary and comparative oncology

Sorenmo KU, Goldschmidt MH, Shofer FS, Goldkamp C, Ferracone J.
PMID: 19379307
Vet Comp Oncol. 2004 Mar;2(1):13-23. doi: 10.1111/j.1476-5810.2004.00035.x.

Prostatic carcinoma occurs primarily in older castrated male dogs and is typically a fatal disease (most dogs die within few months after the initial diagnosis). Surgery, i.e., total prostatectomy, or radiation therapy is often not pursued due to risks...

Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome.

Therapeutics and clinical risk management

Mannaioni G, Baronti R, Moroni F.
PMID: 18360563
Ther Clin Risk Manag. 2005 Sep;1(3):225-30.

BACKGROUND: Neuroleptic malignant syndrome (NMS) is a rare side effect of antipsychotic therapy characterized by fever, muscular rigidity, altered mental status, increased level of serum creatinine phosphokinase, and increased number of white blood cells. The mortality rate of patients...

Showing 13 to 24 of 69 entries