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Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy.

The world journal of men's health

Casado E, Borque-Fernando A, Caamaño M, Graña J, Muñoz-Rodríguez J, Morote J.
PMID: 34983087
World J Mens Health. 2022 Jan;40(1):74-86. doi: 10.5534/wjmh.210061.

Patients with prostate cancer (PCa) on androgen-deprivation therapy (ADT) are at high risk of osteoporosis and fragility fractures. We aimed to provide some practical insights into the delivery of optimal bone health care for PCa patients, particularly those on...

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Casado E, Borque-Fernando A, Caamaño M, et al. Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy. World J Mens Health. 2022;40(1):74-86doi: 10.5534/wjmh.210061.
Casado, E., Borque-Fernando, A., Caamaño, M., Graña, J., Muñoz-Rodríguez, J., & Morote, J. (2022). Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy. The world journal of men's health, 40(1), 74-86. https://doi.org/10.5534/wjmh.210061
Casado, Enrique, et al. "Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy." The world journal of men's health vol. 40,1 (2022): 74-86. doi: https://doi.org/10.5534/wjmh.210061
Casado E, Borque-Fernando A, Caamaño M, Graña J, Muñoz-Rodríguez J, Morote J. Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy. World J Mens Health. 2022 Jan;40(1):74-86. doi: 10.5534/wjmh.210061. PMID: 34983087.
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Photovoltaic activity of layered zirconium phosphates containing covalently grafted ruthenium tris(bipyridyl) and diquat phosphonates as electron donor/acceptor sites.

Physical chemistry chemical physics : PCCP

Teruel L, Alonso M, Quintana MC, Salvador A, Juanes O, Rodriguez-Ubis JC, Brunet E, García H.
PMID: 19421507
Phys Chem Chem Phys. 2009 Apr 28;11(16):2922-7. doi: 10.1039/b816698f. Epub 2009 Feb 10.

Two layered zirconium phosphates containing Ru(bpy)(3)(2+) mono- or diphosphonates and diquat, {Ru(bpy)(3)(2+)[]/ZrP/DQ(++)} and Ru(bpy)(3)(2+)[]/ZrP/DQ(++), covalently attached to the phosphate layers exhibit notable photovoltaic response (the maximum V(OC), J(SC), and FF were 0.093 V, 16.8 microA cm(-2) and 0.33, respectively)....

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Teruel L, Alonso M, Quintana MC, et al. Photovoltaic activity of layered zirconium phosphates containing covalently grafted ruthenium tris(bipyridyl) and diquat phosphonates as electron donor/acceptor sites. Phys Chem Chem Phys. 2009;11(16):2922-7doi: 10.1039/b816698f.
Teruel, L., Alonso, M., Quintana, M. C., Salvador, A., Juanes, O., Rodriguez-Ubis, J. C., Brunet, E., & García, H. (2009). Photovoltaic activity of layered zirconium phosphates containing covalently grafted ruthenium tris(bipyridyl) and diquat phosphonates as electron donor/acceptor sites. Physical chemistry chemical physics : PCCP, 11(16), 2922-7. https://doi.org/10.1039/b816698f
Teruel, Laura, et al. "Photovoltaic activity of layered zirconium phosphates containing covalently grafted ruthenium tris(bipyridyl) and diquat phosphonates as electron donor/acceptor sites." Physical chemistry chemical physics : PCCP vol. 11,16 (2009): 2922-7. doi: https://doi.org/10.1039/b816698f
Teruel L, Alonso M, Quintana MC, Salvador A, Juanes O, Rodriguez-Ubis JC, Brunet E, García H. Photovoltaic activity of layered zirconium phosphates containing covalently grafted ruthenium tris(bipyridyl) and diquat phosphonates as electron donor/acceptor sites. Phys Chem Chem Phys. 2009 Apr 28;11(16):2922-7. doi: 10.1039/b816698f. Epub 2009 Feb 10. PMID: 19421507.
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Template-Directed One- and Two-Dimensional Copper(II) Diphosphonates: Structures and Characterizations of (NH(4))(2)Cu(3)(hedp)(2)(H(2)O)(4), [NH(3)(CH(2))(4)NH(3)]Cu(3)(hedp)(2).2H(2)O, and [NH(2)(C(2)H(4))(2)NH(2)]Cu(3)(hedp)(2) (hedp = 1-Hydroxyethylidenediphosphonate).

Inorganic chemistry

Zheng LM, Song HH, Duan CY, Xin XQ.
PMID: 11671251
Inorg Chem. 1999 Nov 01;38(22):5061-5066. doi: 10.1021/ic990481r.

Three new copper(II) diphosphonates, (NH(4))(2)Cu(3)(hedp)(2)(H(2)O)(4) (1), [NH(3)(CH(2))(4)NH(3)]Cu(3)(hedp)(2).2H(2)O (2), and [NH(2)(C(2)H(4))(2)NH(2)]Cu(3)(hedp)(2) (3), where hedp = 1-hydroxyethylidenediphosphonate, have been synthesized and characterized by single-crystal structural analysis. Crystal data: 1, monoclinic, P2(1)/n, a = 6.2137(13) Å, b = 14.747(2) Å, c =...

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Zheng LM, Song HH, Duan CY, et al. Template-Directed One- and Two-Dimensional Copper(II) Diphosphonates: Structures and Characterizations of (NH(4))(2)Cu(3)(hedp)(2)(H(2)O)(4), [NH(3)(CH(2))(4)NH(3)]Cu(3)(hedp)(2).2H(2)O, and [NH(2)(C(2)H(4))(2)NH(2)]Cu(3)(hedp)(2) (hedp = 1-Hydroxyethylidenediphosphonate). Inorg Chem. 1999;38(22):5061-5066doi: 10.1021/ic990481r.
Zheng, L. M., Song, H. H., Duan, C. Y., & Xin, X. Q. (1999). Template-Directed One- and Two-Dimensional Copper(II) Diphosphonates: Structures and Characterizations of (NH(4))(2)Cu(3)(hedp)(2)(H(2)O)(4), [NH(3)(CH(2))(4)NH(3)]Cu(3)(hedp)(2).2H(2)O, and [NH(2)(C(2)H(4))(2)NH(2)]Cu(3)(hedp)(2) (hedp = 1-Hydroxyethylidenediphosphonate). Inorganic chemistry, 38(22), 5061-5066. https://doi.org/10.1021/ic990481r
Zheng, Li-Min, et al. "Template-Directed One- and Two-Dimensional Copper(II) Diphosphonates: Structures and Characterizations of (NH(4))(2)Cu(3)(hedp)(2)(H(2)O)(4), [NH(3)(CH(2))(4)NH(3)]Cu(3)(hedp)(2).2H(2)O, and [NH(2)(C(2)H(4))(2)NH(2)]Cu(3)(hedp)(2) (hedp = 1-Hydroxyethylidenediphosphonate)." Inorganic chemistry vol. 38,22 (1999): 5061-5066. doi: https://doi.org/10.1021/ic990481r
Zheng LM, Song HH, Duan CY, Xin XQ. Template-Directed One- and Two-Dimensional Copper(II) Diphosphonates: Structures and Characterizations of (NH(4))(2)Cu(3)(hedp)(2)(H(2)O)(4), [NH(3)(CH(2))(4)NH(3)]Cu(3)(hedp)(2).2H(2)O, and [NH(2)(C(2)H(4))(2)NH(2)]Cu(3)(hedp)(2) (hedp = 1-Hydroxyethylidenediphosphonate). Inorg Chem. 1999 Nov 01;38(22):5061-5066. doi: 10.1021/ic990481r. PMID: 11671251.
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One-dimensional cobalt diphosphonates exhibiting weak ferromagnetism and field-induced magnetic transitions.

Inorganic chemistry

Zheng LM, Gao S, Yin P, Xin XQ.
PMID: 15018539
Inorg Chem. 2004 Mar 22;43(6):2151-6. doi: 10.1021/ic034614r.

This paper reports two new cobalt phosphonate compounds [NH3(CH2)nNH3]Co2(hedpH)2.2H2O [n = 4 (1), 5 (2)], where hedp is (1-hydroxyethylidene)diphosphonate [CH3C(OH)(PO3)2]. Both contain ladderlike chains with the same composition [Co2(hedpH)2](n)(2n-), where edge-shared [CoO6] octahedra are each bridged by O-P-O units....

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Zheng LM, Gao S, Yin P, et al. One-dimensional cobalt diphosphonates exhibiting weak ferromagnetism and field-induced magnetic transitions. Inorg Chem. 2004;43(6):2151-6doi: 10.1021/ic034614r.
Zheng, L. M., Gao, S., Yin, P., & Xin, X. Q. (2004). One-dimensional cobalt diphosphonates exhibiting weak ferromagnetism and field-induced magnetic transitions. Inorganic chemistry, 43(6), 2151-6. https://doi.org/10.1021/ic034614r
Zheng, Li-Min, et al. "One-dimensional cobalt diphosphonates exhibiting weak ferromagnetism and field-induced magnetic transitions." Inorganic chemistry vol. 43,6 (2004): 2151-6. doi: https://doi.org/10.1021/ic034614r
Zheng LM, Gao S, Yin P, Xin XQ. One-dimensional cobalt diphosphonates exhibiting weak ferromagnetism and field-induced magnetic transitions. Inorg Chem. 2004 Mar 22;43(6):2151-6. doi: 10.1021/ic034614r. PMID: 15018539.
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The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats.

Journal of the Korean Association of Oral and Maxillofacial Surgeons

Yadegari A, Aminzadeh A, Seyyedkhamesi S, Aminian M.
PMID: 32855374
J Korean Assoc Oral Maxillofac Surg. 2020 Aug 31;46(4):266-274. doi: 10.5125/jkaoms.2020.46.4.266.

OBJECTIVES: Melatonin induces human stem cells, converts pre-osteoblasts to mature osteoblasts, and reduces the duration of this transition. However, melatonin itself prevents activation of osteoclasts. Here, we evaluate the role of melatonin in prevention of bisphosphonate-related osteonecrosis of the...

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Yadegari A, Aminzadeh A, Seyyedkhamesi S, et al. The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats. J Korean Assoc Oral Maxillofac Surg. 2020;46(4):266-274doi: 10.5125/jkaoms.2020.46.4.266.
Yadegari, A., Aminzadeh, A., Seyyedkhamesi, S., & Aminian, M. (2020). The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 46(4), 266-274. https://doi.org/10.5125/jkaoms.2020.46.4.266
Yadegari, Afshin, et al. "The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats." Journal of the Korean Association of Oral and Maxillofacial Surgeons vol. 46,4 (2020): 266-274. doi: https://doi.org/10.5125/jkaoms.2020.46.4.266
Yadegari A, Aminzadeh A, Seyyedkhamesi S, Aminian M. The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats. J Korean Assoc Oral Maxillofac Surg. 2020 Aug 31;46(4):266-274. doi: 10.5125/jkaoms.2020.46.4.266. PMID: 32855374; PMCID: PMC7469961.
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Two New Sandwich-Type Polyoxomolybdates Functionalized with Diphosphonates: Efficient and Selective Oxidation of Sulfides to Sulfones.

Materials (Basel, Switzerland)

Xu Q, Sun X, Hu F, Wan R, Singh V, Ma P, Niu J, Wang J.
PMID: 29027947
Materials (Basel). 2017 Oct 13;10(10). doi: 10.3390/ma10101173.

Two sandwich-type polyoxomolybdates Na₈[MO₂{Mo₂O₅(O₃PCH₃C(O)PO₃)}₂] (M = Ni

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Xu Q, Sun X, Hu F, et al. Two New Sandwich-Type Polyoxomolybdates Functionalized with Diphosphonates: Efficient and Selective Oxidation of Sulfides to Sulfones. Materials (Basel). 2017;10(10)doi: 10.3390/ma10101173.
Xu, Q., Sun, X., Hu, F., Wan, R., Singh, V., Ma, P., Niu, J., & Wang, J. (2017). Two New Sandwich-Type Polyoxomolybdates Functionalized with Diphosphonates: Efficient and Selective Oxidation of Sulfides to Sulfones. Materials (Basel, Switzerland), 10(10), . https://doi.org/10.3390/ma10101173
Xu, Qiaofei, et al. "Two New Sandwich-Type Polyoxomolybdates Functionalized with Diphosphonates: Efficient and Selective Oxidation of Sulfides to Sulfones." Materials (Basel, Switzerland) vol. 10,10 (2017). doi: https://doi.org/10.3390/ma10101173
Xu Q, Sun X, Hu F, Wan R, Singh V, Ma P, Niu J, Wang J. Two New Sandwich-Type Polyoxomolybdates Functionalized with Diphosphonates: Efficient and Selective Oxidation of Sulfides to Sulfones. Materials (Basel). 2017 Oct 13;10(10). doi: 10.3390/ma10101173. PMID: 29027947; PMCID: PMC5666979.
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Structural variety within gallium diphosphonates affected by the organic linker length.

Inorganic chemistry

Attfield MP, Yuan Z, Harvey HG, Clegg W.
PMID: 20166715
Inorg Chem. 2010 Mar 15;49(6):2656-66. doi: 10.1021/ic901651d.

Three new gallium diphosphonates: Ga(3)(OH)(O(3)PC(3)H(6)PO(3))(2) (1), Ga(4)(O(3)PC(5)H(10)PO(3))(3)(C(5)H(5)N)(2) (2), and Ga(HO(3)PC(10)H(20)PO(3)) (3), in which the diphosphonate bridging ligands have 3, 5, and 10 methylene units, respectively, have been synthesized using solvothermal methods and their structures determined using single-crystal laboratory and...

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Attfield MP, Yuan Z, Harvey HG, et al. Structural variety within gallium diphosphonates affected by the organic linker length. Inorg Chem. 2010;49(6):2656-66doi: 10.1021/ic901651d.
Attfield, M. P., Yuan, Z., Harvey, H. G., & Clegg, W. (2010). Structural variety within gallium diphosphonates affected by the organic linker length. Inorganic chemistry, 49(6), 2656-66. https://doi.org/10.1021/ic901651d
Attfield, Martin P, et al. "Structural variety within gallium diphosphonates affected by the organic linker length." Inorganic chemistry vol. 49,6 (2010): 2656-66. doi: https://doi.org/10.1021/ic901651d
Attfield MP, Yuan Z, Harvey HG, Clegg W. Structural variety within gallium diphosphonates affected by the organic linker length. Inorg Chem. 2010 Mar 15;49(6):2656-66. doi: 10.1021/ic901651d. PMID: 20166715.
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Methods to shorten the duration of an external fixator in the management of tibial infections.

World journal of orthopedics

Emara KM, Ghafar KA, Al Kersh MA.
PMID: 22474640
World J Orthop. 2011 Sep 18;2(9):85-92. doi: 10.5312/wjo.v2.i9.85.

Massive segmental bone loss due to chronic osteomyelitis represents a considerable challenge to orthopedic surgeons and is a limb threatening condition. The only option available in such a clinical situation is segment transport using the Ilizarov technique of distraction...

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Emara KM, Ghafar KA, Al Kersh MA. Methods to shorten the duration of an external fixator in the management of tibial infections. World J Orthop. 2011;2(9):85-92doi: 10.5312/wjo.v2.i9.85.
Emara, K. M., Ghafar, K. A., & Al Kersh, M. A. (2011). Methods to shorten the duration of an external fixator in the management of tibial infections. World journal of orthopedics, 2(9), 85-92. https://doi.org/10.5312/wjo.v2.i9.85
Emara, Khaled M, et al. "Methods to shorten the duration of an external fixator in the management of tibial infections." World journal of orthopedics vol. 2,9 (2011): 85-92. doi: https://doi.org/10.5312/wjo.v2.i9.85
Emara KM, Ghafar KA, Al Kersh MA. Methods to shorten the duration of an external fixator in the management of tibial infections. World J Orthop. 2011 Sep 18;2(9):85-92. doi: 10.5312/wjo.v2.i9.85. PMID: 22474640; PMCID: PMC3302046.
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Incorporation of Cu(2+) ions into nanotubular uranyl diphosphonates.

Inorganic chemistry

Adelani PO, Cook ND, Babo JM, Burns PC.
PMID: 24702541
Inorg Chem. 2014 Apr 21;53(8):4169-76. doi: 10.1021/ic500220d. Epub 2014 Apr 04.

Three new multidimensional polymetallic uranyl diphosphonates were crystallized under mild hydrothermal conditions: [Cu(H2O)]2{(UO2)4F2[(PO3C6H4)(C6H4PO3H)3]2(bipym)}·6H2O (1), [Cu(H2O)]2{(UO2)4[(C6H4PO3)(C6H4PO3H)]4(bipym)} (2), and Cu{(UO2)(C6H4PO3)2(bipym)}·H2O (3). Compound 1 consists of UO6F pentagonal bipyramids connected by diphosphonate moieties into a tubular channel. The Cu(2+) cations are stabilized...

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Adelani PO, Cook ND, Babo JM, et al. Incorporation of Cu(2+) ions into nanotubular uranyl diphosphonates. Inorg Chem. 2014;53(8):4169-76doi: 10.1021/ic500220d.
Adelani, P. O., Cook, N. D., Babo, J. M., & Burns, P. C. (2014). Incorporation of Cu(2+) ions into nanotubular uranyl diphosphonates. Inorganic chemistry, 53(8), 4169-76. https://doi.org/10.1021/ic500220d
Adelani, Pius O, et al. "Incorporation of Cu(2+) ions into nanotubular uranyl diphosphonates." Inorganic chemistry vol. 53,8 (2014): 4169-76. doi: https://doi.org/10.1021/ic500220d
Adelani PO, Cook ND, Babo JM, Burns PC. Incorporation of Cu(2+) ions into nanotubular uranyl diphosphonates. Inorg Chem. 2014 Apr 21;53(8):4169-76. doi: 10.1021/ic500220d. Epub 2014 Apr 04. PMID: 24702541.
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Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea.

Journal of bone metabolism

Lee SH, Gong HS, Kim TH, Park SY, Shin JH, Cho SW, Byun DW.
PMID: 26713307
J Bone Metab. 2015 Nov;22(4):167-74. doi: 10.11005/jbm.2015.22.4.167. Epub 2015 Nov 30.

Bisphosphonates have been widely used in the treatment of osteoporosis with robust data from many placebo-controlled trials demonstrating its efficacy in fracture risk reduction over 3 to 5 years of treatment. Although bisphosphonates are generally safe and well tolerated,...

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Lee SH, Gong HS, Kim TH, et al. Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea. J Bone Metab. 2015;22(4):167-74doi: 10.11005/jbm.2015.22.4.167.
Lee, S. H., Gong, H. S., Kim, T. H., Park, S. Y., Shin, J. H., Cho, S. W., & Byun, D. W. (2015). Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea. Journal of bone metabolism, 22(4), 167-74. https://doi.org/10.11005/jbm.2015.22.4.167
Lee, Seung Hun, et al. "Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea." Journal of bone metabolism vol. 22,4 (2015): 167-74. doi: https://doi.org/10.11005/jbm.2015.22.4.167
Lee SH, Gong HS, Kim TH, Park SY, Shin JH, Cho SW, Byun DW. Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea. J Bone Metab. 2015 Nov;22(4):167-74. doi: 10.11005/jbm.2015.22.4.167. Epub 2015 Nov 30. PMID: 26713307; PMCID: PMC4691590.
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Complex Regional Pain Syndrome Type I Following Non-Orthopedic Surgery: Case Report and Narrative Review.

Diagnostics (Basel, Switzerland)

Moretti A, Gimigliano F, Paoletta M, Bertone M, Liguori S, Toro G, Iolascon G.
PMID: 34573938
Diagnostics (Basel). 2021 Sep 01;11(9). doi: 10.3390/diagnostics11091596.

Complex regional pain syndrome type I (CRPS I)-or algodystrophy-is a rare disease that usually occurs after a traumatic event. It is characterized by typical clinical findings such as severe and disabling pain disproportionate to the injury, functional limitations, as...

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Moretti A, Gimigliano F, Paoletta M, et al. Complex Regional Pain Syndrome Type I Following Non-Orthopedic Surgery: Case Report and Narrative Review. Diagnostics (Basel). 2021;11(9)doi: 10.3390/diagnostics11091596.
Moretti, A., Gimigliano, F., Paoletta, M., Bertone, M., Liguori, S., Toro, G., & Iolascon, G. (2021). Complex Regional Pain Syndrome Type I Following Non-Orthopedic Surgery: Case Report and Narrative Review. Diagnostics (Basel, Switzerland), 11(9), . https://doi.org/10.3390/diagnostics11091596
Moretti, Antimo, et al. "Complex Regional Pain Syndrome Type I Following Non-Orthopedic Surgery: Case Report and Narrative Review." Diagnostics (Basel, Switzerland) vol. 11,9 (2021). doi: https://doi.org/10.3390/diagnostics11091596
Moretti A, Gimigliano F, Paoletta M, Bertone M, Liguori S, Toro G, Iolascon G. Complex Regional Pain Syndrome Type I Following Non-Orthopedic Surgery: Case Report and Narrative Review. Diagnostics (Basel). 2021 Sep 01;11(9). doi: 10.3390/diagnostics11091596. PMID: 34573938; PMCID: PMC8465880.
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Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses.

Journal of oral biology and craniofacial research

Muniz FWMG, Silva BFD, Goulart CR, Silveira TMD, Martins TM.
PMID: 33537188
J Oral Biol Craniofac Res. 2021 Apr-Jun;11(2):158-168. doi: 10.1016/j.jobcr.2021.01.008. Epub 2021 Jan 21.

BACKGROUND: Previous systematic reviews showed additional benefit of adjuvant bisphosphonates (BP) in the treatment of periodontitis. In contrast, it is unclear the effect of BP in patients with diabetes and smokers, its pooled effect when administered locally or systemically...

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Muniz FWMG, Silva BFD, Goulart CR, et al. Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses. J Oral Biol Craniofac Res. 2021;11(2):158-168doi: 10.1016/j.jobcr.2021.01.008.
Muniz, F. W. M. G., Silva, B. F. D., Goulart, C. R., Silveira, T. M. D., & Martins, T. M. (2021). Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses. Journal of oral biology and craniofacial research, 11(2), 158-168. https://doi.org/10.1016/j.jobcr.2021.01.008
Muniz, Francisco Wilker Mustafa Gomes, et al. "Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses." Journal of oral biology and craniofacial research vol. 11,2 (2021): 158-168. doi: https://doi.org/10.1016/j.jobcr.2021.01.008
Muniz FWMG, Silva BFD, Goulart CR, Silveira TMD, Martins TM. Effect of adjuvant bisphosphonates on treatment of periodontitis: Systematic review with meta-analyses. J Oral Biol Craniofac Res. 2021 Apr-Jun;11(2):158-168. doi: 10.1016/j.jobcr.2021.01.008. Epub 2021 Jan 21. PMID: 33537188; PMCID: PMC7841362.
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