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Showing 25 to 36 of 2125 entries
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Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy.

Optics express

Rappaz B, Moon I, Yi F, Javidi B, Marquet P, Turcatti G.
PMID: 26074583
Opt Express. 2015 May 18;23(10):13333-47. doi: 10.1364/OE.23.013333.

Compounds tested during drug development may have adverse effects on the heart; therefore all new chemical entities have to undergo extensive preclinical assessment for cardiac liability. Conventional intensity-based imaging techniques are not robust enough to provide detailed information for...

Experiences from Garbha-Swasthya helpline.

Indian journal of public health

Godbole KG, Kulkarni SS, Godbole GP, Kulkarni AM.
PMID: 26021655
Indian J Public Health. 2015 Apr-Jun;59(2):149-52. doi: 10.4103/0019-557X.157538.

Garbha-Swasthya helpline is a telephone helpline run by a tertiary care private hospital to address issues related to pregnancy and its complications. A review of the helpline data from September 2010 to December 2012 was conducted to study caller...

Toxicophores, reactive metabolites and drug safety: when is it a cause for concern?.

Expert review of clinical pharmacology

Kalgutkar AS, Fate G, Didiuk MT, Bauman J.
PMID: 24410554
Expert Rev Clin Pharmacol. 2008 Jul;1(4):515-31. doi: 10.1586/17512433.1.4.515.

It is generally accepted that bioactivation of relatively inert functional groups (toxicophores) to reactive metabolites is an obligatory step in the pathogenesis of certain idiosyncratic adverse drug reactions (IADRs). IADRs cannot be detected in regulatory animal toxicity studies and,...

PRESCRIBING AND RESEARCH IN MEDICINES MANAGEMENT (UK & IRELAND) CONFERENCE 2015 IMPERIAL HOTEL LONDON JANUARY 23.

Pharmacoepidemiology and drug safety

[No authors listed]
PMID: 26075570
Pharmacoepidemiol Drug Saf. 2018 Jul;27(7):O15-O44. doi: 10.1002/pds.3812. Epub 2015 Jun 15.

No abstract available.

Real-world analysis of the Celgene Global Drug Safety database: early discontinuation of lenalidomide in patients with myelodysplastic syndromes due to non-serious rash.

Therapeutics and clinical risk management

Weiss L, Gary D, Swern AS, Freeman J, Sugrue MM.
PMID: 26379438
Ther Clin Risk Manag. 2015 Sep 04;11:1355-60. doi: 10.2147/TCRM.S86449. eCollection 2015.

BACKGROUND: Lenalidomide is approved for treating transfusion-dependent anemia due to lower-risk del(5q) myelodysplastic syndromes (MDS). In clinical trials, rash was common, although severe rash was infrequent. To examine rash in patients with MDS treated with lenalidomide in the real...

Clinical Trial Electronic Portals for Expedited Safety Reporting: Recommendations from the Clinical Trials Transformation Initiative Investigational New Drug Safety Advancement Project.

JMIR cancer

Perez RP, Finnigan S, Patel K, Whitney S, Forrest A.
PMID: 28410179
JMIR Cancer. 2016 Dec 15;2(2):e16. doi: 10.2196/cancer.6701.

BACKGROUND: Use of electronic clinical trial portals has increased in recent years to assist with sponsor-investigator communication, safety reporting, and clinical trial management. Electronic portals can help reduce time and costs associated with processing paperwork and add security measures;...

The role of cytochrome P450 pharmacogenomics in chronic non-cancer pain patients.

Expert opinion on drug metabolism & toxicology

Tverdohleb T, Dinc B, Knezevic I, Candido KD, Knezevic NN.
PMID: 27388970
Expert Opin Drug Metab Toxicol. 2016 Nov;12(11):1303-1311. doi: 10.1080/17425255.2016.1209482. Epub 2016 Jul 15.

INTRODUCTION: Pharmacogenomics is the field that studies an individualized treatment approach for patients' medication regimen that can impact drug safety, productivity, and personalized health care. Pharmacogenomics characterizes the genetic differences in metabolic pathways which can affect a patient's individual...

MicroRNAs in Drug-induced Liver Injury.

Journal of clinical and translational hepatology

Li LM, Wang D, Zen K.
PMID: 26357624
J Clin Transl Hepatol. 2014 Sep;2(3):162-9. doi: 10.14218/JCTH.2014.00015. Epub 2014 Sep 15.

Drug-induced liver injury (DILI) is a leading cause of acute liver failure, and a major reason for the recall of marketed drugs. Detection of potential liver injury is a challenge for clinical management and preclinical drug safety studies, as...

Spontaneously reported haemorrhagic adverse events associated with rivaroxaban and dabigatran in Australia.

Therapeutic advances in drug safety

Chen EY, Diug B, Bell JS, Mc Namara KP, Dooley MJ, Kirkpatrick CM, McNeil JJ, Caughey GE, Ilomäki J.
PMID: 26834958
Ther Adv Drug Saf. 2016 Feb;7(1):4-10. doi: 10.1177/2042098615618171.

OBJECTIVES: The objective of our study was to describe spontaneously reported haemorrhagic adverse events associated with rivaroxaban and dabigatran in Australia.METHODS: Data were sourced from the Australian Therapeutic Goods Administration (TGA) Database of Adverse Event Notifications between June 2009...

Proton pump inhibitors and risk of readmission and mortality in older patients discharged from a tertiary hospital to residential aged care facilities.

Therapeutic advances in drug safety

Pegoli MA, Dedigama M, Mangoni AA, Russell PT, Grzeskowiak LE, Thynne T.
PMID: 28439400
Ther Adv Drug Saf. 2017 Apr;8(4):137-139. doi: 10.1177/2042098616679814. Epub 2016 Nov 29.

No abstract available.

Risk of intracranial hypertension with intrauterine levonorgestrel: reply.

Therapeutic advances in drug safety

Etminan M.
PMID: 26834961
Ther Adv Drug Saf. 2016 Feb;7(1):25-6. doi: 10.1177/2042098615621264.

No abstract available.

Solifenacin linked QT interval prolongation and torsades de pointes.

Therapeutic advances in drug safety

Bray JJH, Hancox JC.
PMID: 28845232
Ther Adv Drug Saf. 2017 Jul;8(7):245-247. doi: 10.1177/2042098617702616. Epub 2017 Apr 10.

No abstract available.

Showing 25 to 36 of 2125 entries