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Therapeutic Potential of Ecdysteroids and Steroidal Alkaloids on Solid Cancers.

The Gulf journal of oncology

Cutajar C, Farrugia M, Agius JC, Wismayer PS.
PMID: 35017138
Gulf J Oncolog. 2021 May;1(36):67-71.

BACKGROUND: Cancer is the second most common cause of death globally. Common modalities of treatment include surgery, chemotherapy, radiotherapy and lately immunotherapy. Different steroidal agents have also been identified as therapeutics for solid cancers, often as part of chemotherapy...

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Cutajar C, Farrugia M, Agius JC, et al. Therapeutic Potential of Ecdysteroids and Steroidal Alkaloids on Solid Cancers. Gulf J Oncolog. 2021;1(36):67-71
Cutajar, C., Farrugia, M., Agius, J. C., & Wismayer, P. S. (2021). Therapeutic Potential of Ecdysteroids and Steroidal Alkaloids on Solid Cancers. The Gulf journal of oncology, 1(36), 67-71.
Cutajar, Catriona, et al. "Therapeutic Potential of Ecdysteroids and Steroidal Alkaloids on Solid Cancers." The Gulf journal of oncology vol. 1,36 (2021): 67-71.
Cutajar C, Farrugia M, Agius JC, Wismayer PS. Therapeutic Potential of Ecdysteroids and Steroidal Alkaloids on Solid Cancers. Gulf J Oncolog. 2021 May;1(36):67-71. PMID: 35017138.
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[No title available]

Pharmaceuticals (Basel, Switzerland)

Shantanova LN, Olennikov DN, Matkhanov IE, Gulyaev SM, Toropova AA, Nikolaeva IG, Nikolaev SM.
PMID: 34832968
Pharmaceuticals (Basel). 2021 Nov 19;14(11). doi: 10.3390/ph14111186.

In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e.,...

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Shantanova LN, Olennikov DN, Matkhanov IE, et al. . Pharmaceuticals (Basel). 2021;14(11)doi: 10.3390/ph14111186.
Shantanova, L. N., Olennikov, D. N., Matkhanov, I. E., Gulyaev, S. M., Toropova, A. A., Nikolaeva, I. G., & Nikolaev, S. M. (2021). . Pharmaceuticals (Basel, Switzerland), 14(11), . https://doi.org/10.3390/ph14111186
Shantanova, Larisa N, et al. "." Pharmaceuticals (Basel, Switzerland) vol. 14,11 (2021). doi: https://doi.org/10.3390/ph14111186
Shantanova LN, Olennikov DN, Matkhanov IE, Gulyaev SM, Toropova AA, Nikolaeva IG, Nikolaev SM. . Pharmaceuticals (Basel). 2021 Nov 19;14(11). doi: 10.3390/ph14111186. PMID: 34832968; PMCID: PMC8621925.
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Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene .

Frontiers in physiology

Peng L, Wang L, Zou MM, Vasseur L, Chu LN, Qin YD, Zhai YL, You MS.
PMID: 31555150
Front Physiol. 2019 Aug 28;10:1120. doi: 10.3389/fphys.2019.01120. eCollection 2019.

Ecdysteroids play an essential role in controlling insect development and reproduction. Their pathway is regulated by a group of enzymes called Halloween gene proteins. The relationship between the Halloween genes and ecdysteroid synthesis has yet to be clearly understood...

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Peng L, Wang L, Zou MM, et al. Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene . Front Physiol. 2019;10:1120doi: 10.3389/fphys.2019.01120.
Peng, L., Wang, L., Zou, M. M., Vasseur, L., Chu, L. N., Qin, Y. D., Zhai, Y. L., & You, M. S. (2019). Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene . Frontiers in physiology, 101120. https://doi.org/10.3389/fphys.2019.01120
Peng, Lu, et al. "Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene ." Frontiers in physiology vol. 10 (2019): 1120. doi: https://doi.org/10.3389/fphys.2019.01120
Peng L, Wang L, Zou MM, Vasseur L, Chu LN, Qin YD, Zhai YL, You MS. Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene . Front Physiol. 2019 Aug 28;10:1120. doi: 10.3389/fphys.2019.01120. eCollection 2019. PMID: 31555150; PMCID: PMC6724230.
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20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor.

Journal of molecular endocrinology

Lafont R, Serova M, Didry-Barca B, Raynal S, Guibout L, Dinan L, Veillet S, Latil M, Dioh W, Dilda PJ.
PMID: 34825653
J Mol Endocrinol. 2021 Dec 23;68(2):77-87. doi: 10.1530/JME-21-0033.

20-Hydroxyecdysone (20E) is a steroid hormone that plays a key role in insect development through nuclear ecdysteroid receptors (EcR/RXR complex) and at least one membrane GPCR receptor (DopEcR). It also displays numerous pharmacological effects in mammals, where its mechanism...

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Lafont R, Serova M, Didry-Barca B, et al. 20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor. J Mol Endocrinol. 2021;68(2):77-87doi: 10.1530/JME-21-0033.
Lafont, R., Serova, M., Didry-Barca, B., Raynal, S., Guibout, L., Dinan, L., Veillet, S., Latil, M., Dioh, W., & Dilda, P. J. (2021). 20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor. Journal of molecular endocrinology, 68(2), 77-87. https://doi.org/10.1530/JME-21-0033
Lafont, René, et al. "20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor." Journal of molecular endocrinology vol. 68,2 (2021): 77-87. doi: https://doi.org/10.1530/JME-21-0033
Lafont R, Serova M, Didry-Barca B, Raynal S, Guibout L, Dinan L, Veillet S, Latil M, Dioh W, Dilda PJ. 20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor. J Mol Endocrinol. 2021 Dec 23;68(2):77-87. doi: 10.1530/JME-21-0033. PMID: 34825653.
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Effects of juvenile hormone on the secretion of prothoracicotropic hormone in the last- and penultimate-instar larvae of the silkworm Bombyx mori.

Journal of insect physiology

Mizoguchi A.
PMID: 11356424
J Insect Physiol. 2001 Jul;47(7):767-775. doi: 10.1016/s0022-1910(01)00052-x.

The effect of juvenile hormone (JH) on the secretion of the prothoracicotropic hormone (PTTH) was investigated, by examining the changes in hemolymph PTTH titer after the topical application of JH-I on the larvae of the silkworm, Bombyx mori. The...

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Mizoguchi A. Effects of juvenile hormone on the secretion of prothoracicotropic hormone in the last- and penultimate-instar larvae of the silkworm Bombyx mori. J Insect Physiol. 2001;47(7):767-775doi: 10.1016/s0022-1910(01)00052-x.
Mizoguchi, A. (2001). Effects of juvenile hormone on the secretion of prothoracicotropic hormone in the last- and penultimate-instar larvae of the silkworm Bombyx mori. Journal of insect physiology, 47(7), 767-775. https://doi.org/10.1016/s0022-1910(01)00052-x
Mizoguchi, A. "Effects of juvenile hormone on the secretion of prothoracicotropic hormone in the last- and penultimate-instar larvae of the silkworm Bombyx mori." Journal of insect physiology vol. 47,7 (2001): 767-775. doi: https://doi.org/10.1016/s0022-1910(01)00052-x
Mizoguchi A. Effects of juvenile hormone on the secretion of prothoracicotropic hormone in the last- and penultimate-instar larvae of the silkworm Bombyx mori. J Insect Physiol. 2001 Jul;47(7):767-775. doi: 10.1016/s0022-1910(01)00052-x. PMID: 11356424.
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Phytoecdysteroids in seeds of Lloydia serotina (Liliaceae).

Biochemical systematics and ecology

Dinan L, Whiting P, Savchenko T.
PMID: 11445293
Biochem Syst Ecol. 2001 Oct;29(9):923-928. doi: 10.1016/s0305-1978(01)00021-7.

Seeds of a number of species in the Liliaceae (sensu Brummitt, 1992) were examined for the presence of ecdysteroid agonist and antagonist activities. No species were antagonistic to 20-hydroxyecdysone action on the ecdysteroid-responsive Drosophila melanogaster B(II) cell line and...

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Dinan L, Whiting P, Savchenko T. Phytoecdysteroids in seeds of Lloydia serotina (Liliaceae). Biochem Syst Ecol. 2001;29(9):923-928doi: 10.1016/s0305-1978(01)00021-7.
Dinan, L., Whiting, P., & Savchenko, T. (2001). Phytoecdysteroids in seeds of Lloydia serotina (Liliaceae). Biochemical systematics and ecology, 29(9), 923-928. https://doi.org/10.1016/s0305-1978(01)00021-7
Dinan, L, et al. "Phytoecdysteroids in seeds of Lloydia serotina (Liliaceae)." Biochemical systematics and ecology vol. 29,9 (2001): 923-928. doi: https://doi.org/10.1016/s0305-1978(01)00021-7
Dinan L, Whiting P, Savchenko T. Phytoecdysteroids in seeds of Lloydia serotina (Liliaceae). Biochem Syst Ecol. 2001 Oct;29(9):923-928. doi: 10.1016/s0305-1978(01)00021-7. PMID: 11445293.
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Ecdysteroid titer, ovary status, and dominance in adult worker and queen bumble bees (Bombus terrestris).

Journal of insect physiology

Bloch G, Hefetz A, Hartfelder K.
PMID: 10802116
J Insect Physiol. 2000 Jun 01;46(6):1033-1040. doi: 10.1016/s0022-1910(99)00214-0.

The role of ecdysteroids in the regulation of dominance and reproduction in social Hymenoptera is little explored. In the current study we compared ecdysteroid titers in hemolymph of individual queen and worker bumble bees (Bombus terrestris) that differ in...

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Bloch G, Hefetz A, Hartfelder K. Ecdysteroid titer, ovary status, and dominance in adult worker and queen bumble bees (Bombus terrestris). J Insect Physiol. 2000;46(6):1033-1040doi: 10.1016/s0022-1910(99)00214-0.
Bloch, G., Hefetz, A., & Hartfelder, K. (2000). Ecdysteroid titer, ovary status, and dominance in adult worker and queen bumble bees (Bombus terrestris). Journal of insect physiology, 46(6), 1033-1040. https://doi.org/10.1016/s0022-1910(99)00214-0
Bloch, et al. "Ecdysteroid titer, ovary status, and dominance in adult worker and queen bumble bees (Bombus terrestris)." Journal of insect physiology vol. 46,6 (2000): 1033-1040. doi: https://doi.org/10.1016/s0022-1910(99)00214-0
Bloch G, Hefetz A, Hartfelder K. Ecdysteroid titer, ovary status, and dominance in adult worker and queen bumble bees (Bombus terrestris). J Insect Physiol. 2000 Jun 01;46(6):1033-1040. doi: 10.1016/s0022-1910(99)00214-0. PMID: 10802116.
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A Role for Ecdysteroids in the Induction and Maintenance of the Pharate First Instar Diapause of the Gypsy Moth, Lymantria dispar.

Journal of insect physiology

DENLINGER DL, LEE K.
PMID: 12769913
J Insect Physiol. 1997 Mar;43(3):289-296. doi: 10.1016/s0022-1910(96)00082-0.

Several lines of evidence suggest a novel regulatory mechanism for diapause regulation in the gypsy moth. We propose that ecdysteroids play a role in the induction and maintenance of the pharate first instar larval diapause in this species. A...

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DENLINGER DL, LEE K. A Role for Ecdysteroids in the Induction and Maintenance of the Pharate First Instar Diapause of the Gypsy Moth, Lymantria dispar. J Insect Physiol. 1997;43(3):289-296doi: 10.1016/s0022-1910(96)00082-0.
DENLINGER, D. L., & LEE, K. (1997). A Role for Ecdysteroids in the Induction and Maintenance of the Pharate First Instar Diapause of the Gypsy Moth, Lymantria dispar. Journal of insect physiology, 43(3), 289-296. https://doi.org/10.1016/s0022-1910(96)00082-0
DENLINGER, D L., and LEE, K -Y.. "A Role for Ecdysteroids in the Induction and Maintenance of the Pharate First Instar Diapause of the Gypsy Moth, Lymantria dispar." Journal of insect physiology vol. 43,3 (1997): 289-296. doi: https://doi.org/10.1016/s0022-1910(96)00082-0
DENLINGER DL, LEE K. A Role for Ecdysteroids in the Induction and Maintenance of the Pharate First Instar Diapause of the Gypsy Moth, Lymantria dispar. J Insect Physiol. 1997 Mar;43(3):289-296. doi: 10.1016/s0022-1910(96)00082-0. PMID: 12769913.
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Titres of biogenic amines and ecdysteroids: effect of octopamine on the production of ecdysteroids in the silkworm Bombyx mori.

Journal of insect physiology

Hirashima A, Hirokado S, Ohta H, Suetsugu E, Sakaguchi M, Kuwano E, Taniguchi E, Eto M.
PMID: 12770297
J Insect Physiol. 1999 Sep;45(9):843-851. doi: 10.1016/s0022-1910(99)00068-2.

At day two, a sharp peak of octopamine (OA) was observed in last instar female Bombyx mori larvae. This peak also appeared in male larvae a day later than in females at day three. An OA peak was also...

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Hirashima A, Hirokado S, Ohta H, et al. Titres of biogenic amines and ecdysteroids: effect of octopamine on the production of ecdysteroids in the silkworm Bombyx mori. J Insect Physiol. 1999;45(9):843-851doi: 10.1016/s0022-1910(99)00068-2.
Hirashima, A., Hirokado, S., Ohta, H., Suetsugu, E., Sakaguchi, M., Kuwano, E., Taniguchi, E., & Eto, M. (1999). Titres of biogenic amines and ecdysteroids: effect of octopamine on the production of ecdysteroids in the silkworm Bombyx mori. Journal of insect physiology, 45(9), 843-851. https://doi.org/10.1016/s0022-1910(99)00068-2
Hirashima, A, et al. "Titres of biogenic amines and ecdysteroids: effect of octopamine on the production of ecdysteroids in the silkworm Bombyx mori." Journal of insect physiology vol. 45,9 (1999): 843-851. doi: https://doi.org/10.1016/s0022-1910(99)00068-2
Hirashima A, Hirokado S, Ohta H, Suetsugu E, Sakaguchi M, Kuwano E, Taniguchi E, Eto M. Titres of biogenic amines and ecdysteroids: effect of octopamine on the production of ecdysteroids in the silkworm Bombyx mori. J Insect Physiol. 1999 Sep;45(9):843-851. doi: 10.1016/s0022-1910(99)00068-2. PMID: 12770297.
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Relationship of the neutral sterols and ecdysteroids of the parasitic mite, Varroa jacobsoni to those of the honey bee, Apis mellifera.

Journal of insect physiology

Hartfelder K, Feldlaufer MF.
PMID: 12770416
J Insect Physiol. 1997 Jun;43(6):541-545. doi: 10.1016/s0022-1910(97)00005-x.

The neutral sterols of the parasitic mite Varroa jacobsoni were compared with Apis mellifera carnica drone pupae. Analysis by GLC-mass spectrometry indicated mite sterols were reflective of the sterol composition of the drones; 24-methylenecholesterol was the major sterol in...

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Hartfelder K, Feldlaufer MF. Relationship of the neutral sterols and ecdysteroids of the parasitic mite, Varroa jacobsoni to those of the honey bee, Apis mellifera. J Insect Physiol. 1997;43(6):541-545doi: 10.1016/s0022-1910(97)00005-x.
Hartfelder, K., & Feldlaufer, M. F. (1997). Relationship of the neutral sterols and ecdysteroids of the parasitic mite, Varroa jacobsoni to those of the honey bee, Apis mellifera. Journal of insect physiology, 43(6), 541-545. https://doi.org/10.1016/s0022-1910(97)00005-x
Hartfelder, K, and Feldlaufer, M F.. "Relationship of the neutral sterols and ecdysteroids of the parasitic mite, Varroa jacobsoni to those of the honey bee, Apis mellifera." Journal of insect physiology vol. 43,6 (1997): 541-545. doi: https://doi.org/10.1016/s0022-1910(97)00005-x
Hartfelder K, Feldlaufer MF. Relationship of the neutral sterols and ecdysteroids of the parasitic mite, Varroa jacobsoni to those of the honey bee, Apis mellifera. J Insect Physiol. 1997 Jun;43(6):541-545. doi: 10.1016/s0022-1910(97)00005-x. PMID: 12770416.
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The relationship between 'critical weight' and 20-hydroxyecdysone in the female ixodid tick, Amblyomma hebraeum.

Journal of insect physiology

Weiss BL, Reuben Kaufman W.
PMID: 12770177
J Insect Physiol. 2001 Nov;47(11):1261-1267. doi: 10.1016/s0022-1910(01)00112-3.

THE FEEDING CYCLE OF ADULT FEMALE TICKS (ACARI: Ixodidae) is divided into preparatory, slow and rapid feeding phases. At the transition from slow to rapid feeding, Amblyomma hebraeum (Koch) females reach a 'critical weight' (CW; approx. 10x the unfed...

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Weiss BL, Reuben Kaufman W. The relationship between 'critical weight' and 20-hydroxyecdysone in the female ixodid tick, Amblyomma hebraeum. J Insect Physiol. 2001;47(11):1261-1267doi: 10.1016/s0022-1910(01)00112-3.
Weiss, B. L., & Reuben Kaufman, W. (2001). The relationship between 'critical weight' and 20-hydroxyecdysone in the female ixodid tick, Amblyomma hebraeum. Journal of insect physiology, 47(11), 1261-1267. https://doi.org/10.1016/s0022-1910(01)00112-3
Weiss, B L., and Reuben Kaufman, W. "The relationship between 'critical weight' and 20-hydroxyecdysone in the female ixodid tick, Amblyomma hebraeum." Journal of insect physiology vol. 47,11 (2001): 1261-1267. doi: https://doi.org/10.1016/s0022-1910(01)00112-3
Weiss BL, Reuben Kaufman W. The relationship between 'critical weight' and 20-hydroxyecdysone in the female ixodid tick, Amblyomma hebraeum. J Insect Physiol. 2001 Nov;47(11):1261-1267. doi: 10.1016/s0022-1910(01)00112-3. PMID: 12770177.
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Poly(A) Binding Protein Is Required for Nuclear Localization of the Ecdysteroidogenic Transcription Factor Molting Defective in the Prothoracic Gland of .

Frontiers in genetics

Kamiyama T, Sun W, Tani N, Nakamura A, Niwa R.
PMID: 32676099
Front Genet. 2020 Jun 26;11:636. doi: 10.3389/fgene.2020.00636. eCollection 2020.

Steroid hormone signaling contributes to the development of multicellular organisms. In insects, ecdysteroids, like ecdysone and the more biologically-active derivative 20-hydroxyecdysone (20E), promote molting and metamorphosis. Ecdysone is biosynthesized in the prothoracic gland (PG),

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Kamiyama T, Sun W, Tani N, et al. Poly(A) Binding Protein Is Required for Nuclear Localization of the Ecdysteroidogenic Transcription Factor Molting Defective in the Prothoracic Gland of . Front Genet. 2020;11:636doi: 10.3389/fgene.2020.00636.
Kamiyama, T., Sun, W., Tani, N., Nakamura, A., & Niwa, R. (2020). Poly(A) Binding Protein Is Required for Nuclear Localization of the Ecdysteroidogenic Transcription Factor Molting Defective in the Prothoracic Gland of . Frontiers in genetics, 11636. https://doi.org/10.3389/fgene.2020.00636
Kamiyama, Takumi, et al. "Poly(A) Binding Protein Is Required for Nuclear Localization of the Ecdysteroidogenic Transcription Factor Molting Defective in the Prothoracic Gland of ." Frontiers in genetics vol. 11 (2020): 636. doi: https://doi.org/10.3389/fgene.2020.00636
Kamiyama T, Sun W, Tani N, Nakamura A, Niwa R. Poly(A) Binding Protein Is Required for Nuclear Localization of the Ecdysteroidogenic Transcription Factor Molting Defective in the Prothoracic Gland of . Front Genet. 2020 Jun 26;11:636. doi: 10.3389/fgene.2020.00636. eCollection 2020. PMID: 32676099; PMCID: PMC7333772.
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Showing 13 to 24 of 120 entries