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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats.

Acta pharmaceutica Sinica. B

Dahlgren D, Olander T, Sjöblom M, Hedeland M, Lennernäs H.
PMID: 34221875
Acta Pharm Sin B. 2021 Jun;11(6):1667-1675. doi: 10.1016/j.apsb.2020.12.019. Epub 2021 Jan 05.

Transcellular permeation enhancers are known to increase the intestinal permeability of enalaprilat, a 349 Da peptide, but not hexarelin (887 Da). The primary aim of this paper was to investigate if paracellular permeability enhancers affected the intestinal permeation of...

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Dahlgren D, Olander T, Sjöblom M, et al. Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats. Acta Pharm Sin B. 2021;11(6):1667-1675doi: 10.1016/j.apsb.2020.12.019.
Dahlgren, D., Olander, T., Sjöblom, M., Hedeland, M., & Lennernäs, H. (2021). Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats. Acta pharmaceutica Sinica. B, 11(6), 1667-1675. https://doi.org/10.1016/j.apsb.2020.12.019
Dahlgren, David, et al. "Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats." Acta pharmaceutica Sinica. B vol. 11,6 (2021): 1667-1675. doi: https://doi.org/10.1016/j.apsb.2020.12.019
Dahlgren D, Olander T, Sjöblom M, Hedeland M, Lennernäs H. Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats. Acta Pharm Sin B. 2021 Jun;11(6):1667-1675. doi: 10.1016/j.apsb.2020.12.019. Epub 2021 Jan 05. PMID: 34221875; PMCID: PMC8245904.
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Evaluation of the hypertensive infant: a rational approach to diagnosis.

Radiologic clinics of North America

Roth CG, Spottswood SE, Chan JC, Roth KS.
PMID: 14521202
Radiol Clin North Am. 2003 Sep;41(5):931-44. doi: 10.1016/s0033-8389(03)00072-1.

This article reviews the literature and describes a methodologic approach to the diagnosis of hypertension in the young infant. The numerous etiologies of hypertension have been discussed and normative blood pressure data for neonates and infants have been provided....

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Roth CG, Spottswood SE, Chan JC, et al. Evaluation of the hypertensive infant: a rational approach to diagnosis. Radiol Clin North Am. 2003;41(5):931-44doi: 10.1016/s0033-8389(03)00072-1.
Roth, C. G., Spottswood, S. E., Chan, J. C., & Roth, K. S. (2003). Evaluation of the hypertensive infant: a rational approach to diagnosis. Radiologic clinics of North America, 41(5), 931-44. https://doi.org/10.1016/s0033-8389(03)00072-1
Roth, Christopher G, et al. "Evaluation of the hypertensive infant: a rational approach to diagnosis." Radiologic clinics of North America vol. 41,5 (2003): 931-44. doi: https://doi.org/10.1016/s0033-8389(03)00072-1
Roth CG, Spottswood SE, Chan JC, Roth KS. Evaluation of the hypertensive infant: a rational approach to diagnosis. Radiol Clin North Am. 2003 Sep;41(5):931-44. doi: 10.1016/s0033-8389(03)00072-1. PMID: 14521202.
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Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures.

Toxicology in vitro : an international journal published in association with BIBRA

Jurima-Romet M, Huang HS.
PMID: 20692951
Toxicol In Vitro. 1994 Aug;8(4):529-31. doi: 10.1016/0887-2333(94)90007-8.

Hepatotoxicity has been reported with angiotensin-converting enzyme (ACE) inhibitors. The mechanism of liver injury is not known. In the present study, primary rat hepatocytes were used to investigate the cytotoxicity of ACE inhibitors. Captopril, enalapril, fosinopril and quinapril were...

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Jurima-Romet M, Huang HS. Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures. Toxicol In Vitro. 1994;8(4):529-31doi: 10.1016/0887-2333(94)90007-8.
Jurima-Romet, M., & Huang, H. S. (1994). Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures. Toxicology in vitro : an international journal published in association with BIBRA, 8(4), 529-31. https://doi.org/10.1016/0887-2333(94)90007-8
Jurima-Romet, M, and Huang, H S. "Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures." Toxicology in vitro : an international journal published in association with BIBRA vol. 8,4 (1994): 529-31. doi: https://doi.org/10.1016/0887-2333(94)90007-8
Jurima-Romet M, Huang HS. Comparison of the cytotoxicity of ACE inhibitors and effects of cytochrome P-450 and glutathione modulation in primary rat hepatocyte cultures. Toxicol In Vitro. 1994 Aug;8(4):529-31. doi: 10.1016/0887-2333(94)90007-8. PMID: 20692951.
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Intracellular Renin Disrupts Chemical Communication between Heart Cells. Pathophysiological Implications.

Frontiers in endocrinology

De Mello WC.
PMID: 25657639
Front Endocrinol (Lausanne). 2015 Jan 22;5:238. doi: 10.3389/fendo.2014.00238. eCollection 2014.

HighlightsIntracellular renin disrupts chemical communication in the heartAngiotensinogen enhances the effect of reninIntracellular enalaprilat reduces significantly the effect of reninIntracellular renin increases the inward calcium currentHarmful versus beneficial effect during myocardial infarction The influence of intracellular renin on the...

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De Mello WC. Intracellular Renin Disrupts Chemical Communication between Heart Cells. Pathophysiological Implications. Front Endocrinol (Lausanne). 2015;5:238doi: 10.3389/fendo.2014.00238.
De Mello, W. C. (2014). Intracellular Renin Disrupts Chemical Communication between Heart Cells. Pathophysiological Implications. Frontiers in endocrinology, 5238. https://doi.org/10.3389/fendo.2014.00238
De Mello, Walmor C. "Intracellular Renin Disrupts Chemical Communication between Heart Cells. Pathophysiological Implications." Frontiers in endocrinology vol. 5 (2014): 238. doi: https://doi.org/10.3389/fendo.2014.00238
De Mello WC. Intracellular Renin Disrupts Chemical Communication between Heart Cells. Pathophysiological Implications. Front Endocrinol (Lausanne). 2015 Jan 22;5:238. doi: 10.3389/fendo.2014.00238. eCollection 2014. PMID: 25657639; PMCID: PMC4303002.
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Improvement of enalapril maleate chemical stability by high shear melting granulation.

Pharmaceutical development and technology

de Oliveira APM, Cunha TA, Serpa RC, Taveira SF, Lima EM, Almeida Diniz DG, de Freitas LAP, Marreto RN.
PMID: 25231642
Pharm Dev Technol. 2015 Dec;20(8):1002-1008. doi: 10.3109/10837450.2014.959178. Epub 2014 Sep 18.

Enalapril maleate is a widely used drug, which is chemically unstable when mixed with excipients resulting in enalaprilat and diketopiperazine as the main degradation products. The preparation of enalapril sodium salt has been used to improve drug stability in...

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de Oliveira APM, Cunha TA, Serpa RC, et al. Improvement of enalapril maleate chemical stability by high shear melting granulation. Pharm Dev Technol. 2014;20(8):1002-1008doi: 10.3109/10837450.2014.959178.
de Oliveira, A. P. M., Cunha, T. A., Serpa, R. C., Taveira, S. F., Lima, E. M., Almeida Diniz, D. G., de Freitas, L. A. P., & Marreto, R. N. (2015). Improvement of enalapril maleate chemical stability by high shear melting granulation. Pharmaceutical development and technology, 20(8), 1002-1008. https://doi.org/10.3109/10837450.2014.959178
de Oliveira, Ana Paula Montandon, et al. "Improvement of enalapril maleate chemical stability by high shear melting granulation." Pharmaceutical development and technology vol. 20,8 (2015): 1002-1008. doi: https://doi.org/10.3109/10837450.2014.959178
de Oliveira APM, Cunha TA, Serpa RC, Taveira SF, Lima EM, Almeida Diniz DG, de Freitas LAP, Marreto RN. Improvement of enalapril maleate chemical stability by high shear melting granulation. Pharm Dev Technol. 2015 Dec;20(8):1002-1008. doi: 10.3109/10837450.2014.959178. Epub 2014 Sep 18. PMID: 25231642.
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Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye.

Nanomedicine : nanotechnology, biology, and medicine

Popova EV, Tikhomirova VE, Beznos OV, Chesnokova NB, Grigoriev YV, Klyachko NL, Kost OA.
PMID: 34775060
Nanomedicine. 2021 Nov 12;40:102493. doi: 10.1016/j.nano.2021.102493. Epub 2021 Nov 12.

Formulations on the base of an inhibitor of angiotensin-converting enzyme, enalaprilat, were prepared by the inclusion of the drug into calcium phosphate (CaP)-particles in situ, followed by the covering of the particles with 5 kDa chitosan or 72 kDa...

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Popova EV, Tikhomirova VE, Beznos OV, et al. Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye. Nanomedicine. 2021;40:102493doi: 10.1016/j.nano.2021.102493.
Popova, E. V., Tikhomirova, V. E., Beznos, O. V., Chesnokova, N. B., Grigoriev, Y. V., Klyachko, N. L., & Kost, O. A. (2021). Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye. Nanomedicine : nanotechnology, biology, and medicine, 40102493. https://doi.org/10.1016/j.nano.2021.102493
Popova, Ekaterina V, et al. "Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye." Nanomedicine : nanotechnology, biology, and medicine vol. 40 (2021): 102493. doi: https://doi.org/10.1016/j.nano.2021.102493
Popova EV, Tikhomirova VE, Beznos OV, Chesnokova NB, Grigoriev YV, Klyachko NL, Kost OA. Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye. Nanomedicine. 2021 Nov 12;40:102493. doi: 10.1016/j.nano.2021.102493. Epub 2021 Nov 12. PMID: 34775060.
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Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye.

Nanomedicine : nanotechnology, biology, and medicine

Popova EV, Tikhomirova VE, Beznos OV, Chesnokova NB, Grigoriev YV, Klyachko NL, Kost OA.
PMID: 34775060
Nanomedicine. 2021 Nov 12;40:102493. doi: 10.1016/j.nano.2021.102493. Epub 2021 Nov 12.

Formulations on the base of an inhibitor of angiotensin-converting enzyme, enalaprilat, were prepared by the inclusion of the drug into calcium phosphate (CaP)-particles in situ, followed by the covering of the particles with 5 kDa chitosan or 72 kDa...

Cite
Popova EV, Tikhomirova VE, Beznos OV, et al. Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye. Nanomedicine. 2021;40:102493doi: 10.1016/j.nano.2021.102493.
Popova, E. V., Tikhomirova, V. E., Beznos, O. V., Chesnokova, N. B., Grigoriev, Y. V., Klyachko, N. L., & Kost, O. A. (2021). Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye. Nanomedicine : nanotechnology, biology, and medicine, 40102493. https://doi.org/10.1016/j.nano.2021.102493
Popova, Ekaterina V, et al. "Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye." Nanomedicine : nanotechnology, biology, and medicine vol. 40 (2021): 102493. doi: https://doi.org/10.1016/j.nano.2021.102493
Popova EV, Tikhomirova VE, Beznos OV, Chesnokova NB, Grigoriev YV, Klyachko NL, Kost OA. Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye. Nanomedicine. 2021 Nov 12;40:102493. doi: 10.1016/j.nano.2021.102493. Epub 2021 Nov 12. PMID: 34775060.
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In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex.

Results in chemistry

Buitrón-González I, Aguilera-Durán G, Romo-Mancillas A.
PMID: 33520633
Results Chem. 2021 Jan;3:100094. doi: 10.1016/j.rechem.2020.100094. Epub 2020 Dec 28.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that leads to coronavirus disease (COVID-19) has put public health at risk in 2020. The spike protein (SP) in SARS-CoV-2 is primarily responsible for the attachment and entry of the virus into...

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Buitrón-González I, Aguilera-Durán G, Romo-Mancillas A. In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex. Results Chem. 2020;3:100094doi: 10.1016/j.rechem.2020.100094.
Buitrón-González, I., Aguilera-Durán, G., & Romo-Mancillas, A. (2021). In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex. Results in chemistry, 3100094. https://doi.org/10.1016/j.rechem.2020.100094
Buitrón-González, Ivonne, et al. "In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex." Results in chemistry vol. 3 (2021): 100094. doi: https://doi.org/10.1016/j.rechem.2020.100094
Buitrón-González I, Aguilera-Durán G, Romo-Mancillas A. In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex. Results Chem. 2021 Jan;3:100094. doi: 10.1016/j.rechem.2020.100094. Epub 2020 Dec 28. PMID: 33520633; PMCID: PMC7834266.
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Showing 49 to 56 of 56 entries