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Showing 13 to 24 of 39 entries
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Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein.

Evidence-based complementary and alternative medicine : eCAM

Chen C, Wu C, Lu X, Yan Z, Gao J, Zhao H, Li S.
PMID: 24058374
Evid Based Complement Alternat Med. 2013;2013:639083. doi: 10.1155/2013/639083. Epub 2013 Aug 24.

Glutathione S-transferase (GST) is the key enzyme in multidrug resistance (MDR) of tumour. Inhibition of the expression or activity of GST has emerged as a promising therapeutic strategy for the reversal of MDR. Coniferyl ferulate (CF), isolated from the...

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Chen C, Wu C, Lu X, et al. Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein. Evid Based Complement Alternat Med. 2013;2013:639083doi: 10.1155/2013/639083.
Chen, C., Wu, C., Lu, X., Yan, Z., Gao, J., Zhao, H., & Li, S. (2013). Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein. Evidence-based complementary and alternative medicine : eCAM, 2013639083. https://doi.org/10.1155/2013/639083
Chen, Chang, et al. "Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 639083. doi: https://doi.org/10.1155/2013/639083
Chen C, Wu C, Lu X, Yan Z, Gao J, Zhao H, Li S. Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein. Evid Based Complement Alternat Med. 2013;2013:639083. doi: 10.1155/2013/639083. Epub 2013 Aug 24. PMID: 24058374; PMCID: PMC3766616.
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Stability of oral liquid dosage forms of ethacrynic Acid.

International journal of pharmaceutical compounding

Ling J, Gupta VD.
PMID: 23981893
Int J Pharm Compd. 2001 May-Jun;5(3):232-3.

The stability of ethacrynic acid (2.5 mg/mL) in oral liquid dosage forms was investigated. Tablets in 0.05 M phosphate buffer (available commercially) in water were used to prepare the dosage forms. The effects of mannitol and sugar on the...

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Ling J, Gupta VD. Stability of oral liquid dosage forms of ethacrynic Acid. Int J Pharm Compd. 2001;5(3):232-3
Ling, J., & Gupta, V. D. (2001). Stability of oral liquid dosage forms of ethacrynic Acid. International journal of pharmaceutical compounding, 5(3), 232-3.
Ling, J, and Gupta, V D. "Stability of oral liquid dosage forms of ethacrynic Acid." International journal of pharmaceutical compounding vol. 5,3 (2001): 232-3.
Ling J, Gupta VD. Stability of oral liquid dosage forms of ethacrynic Acid. Int J Pharm Compd. 2001 May-Jun;5(3):232-3. PMID: 23981893.
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Ethacrynic Acid continuous infusions in critically ill pediatric patients.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Miller JL, Schaefer J, Tam M, Harrison DL, Johnson PN.
PMID: 24782692
J Pediatr Pharmacol Ther. 2014 Jan;19(1):49-55. doi: 10.5863/1551-6776-19.1.49.

OBJECTIVES: The purpose of this study was to describe dosage regimens and treatment outcomes in critically ill children receiving ethacrynic acid continuous infusions (CI).METHODS: This retrospective cross-sectional study evaluated patients less than 18 years of age who received ethacrynic...

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Miller JL, Schaefer J, Tam M, et al. Ethacrynic Acid continuous infusions in critically ill pediatric patients. J Pediatr Pharmacol Ther. 2014;19(1):49-55doi: 10.5863/1551-6776-19.1.49.
Miller, J. L., Schaefer, J., Tam, M., Harrison, D. L., & Johnson, P. N. (2014). Ethacrynic Acid continuous infusions in critically ill pediatric patients. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 19(1), 49-55. https://doi.org/10.5863/1551-6776-19.1.49
Miller, Jamie L, et al. "Ethacrynic Acid continuous infusions in critically ill pediatric patients." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 19,1 (2014): 49-55. doi: https://doi.org/10.5863/1551-6776-19.1.49
Miller JL, Schaefer J, Tam M, Harrison DL, Johnson PN. Ethacrynic Acid continuous infusions in critically ill pediatric patients. J Pediatr Pharmacol Ther. 2014 Jan;19(1):49-55. doi: 10.5863/1551-6776-19.1.49. PMID: 24782692; PMCID: PMC3998969.
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Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation.

Disease markers

Zhang X, Huang C, Cui B, Pang Y, Liang R, Luo X.
PMID: 34122668
Dis Markers. 2021 Apr 27;2021:5530673. doi: 10.1155/2021/5530673. eCollection 2021.

No abstract available.

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Zhang X, Huang C, Cui B, et al. Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation. Dis Markers. 2021;2021:5530673doi: 10.1155/2021/5530673.
Zhang, X., Huang, C., Cui, B., Pang, Y., Liang, R., & Luo, X. (2021). Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation. Disease markers, 20215530673. https://doi.org/10.1155/2021/5530673
Zhang, Xuehui, et al. "Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation." Disease markers vol. 2021 (2021): 5530673. doi: https://doi.org/10.1155/2021/5530673
Zhang X, Huang C, Cui B, Pang Y, Liang R, Luo X. Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation. Dis Markers. 2021 Apr 27;2021:5530673. doi: 10.1155/2021/5530673. eCollection 2021. PMID: 34122668; PMCID: PMC8168479.
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Respiratory adjustment to chronic metabolic alkalosis in man.

The Journal of clinical investigation

Goldring RM, Cannon PJ, Heinemann HO, Fishman AP.
PMID: 16695940
J Clin Invest. 1968 Jan;47(1):188-202. doi: 10.1172/JCI105708.

This study examined the ventilatory adjustment to chronic metabolic alkalosis induced under controlled conditions in normal human volunteers. Metabolic alkalosis induced by buffers (sodium bicarbonate, trishydroxymethylamine methane) or ethacrynic acid was associated with alveolar hypoventilation, as evidenced by a...

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Goldring RM, Cannon PJ, Heinemann HO, et al. Respiratory adjustment to chronic metabolic alkalosis in man. J Clin Invest. 1968;47(1):188-202doi: 10.1172/JCI105708.
Goldring, R. M., Cannon, P. J., Heinemann, H. O., & Fishman, A. P. (1968). Respiratory adjustment to chronic metabolic alkalosis in man. The Journal of clinical investigation, 47(1), 188-202. https://doi.org/10.1172/JCI105708
Goldring, R M, et al. "Respiratory adjustment to chronic metabolic alkalosis in man." The Journal of clinical investigation vol. 47,1 (1968): 188-202. doi: https://doi.org/10.1172/JCI105708
Goldring RM, Cannon PJ, Heinemann HO, Fishman AP. Respiratory adjustment to chronic metabolic alkalosis in man. J Clin Invest. 1968 Jan;47(1):188-202. doi: 10.1172/JCI105708. PMID: 16695940; PMCID: PMC297159.
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Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents.

Bioorganic chemistry

El Abbouchi A, El Brahmi N, Hiebel MA, Bignon J, Guillaumet G, Suzenet F, El Kazzouli S.
PMID: 34426162
Bioorg Chem. 2021 Oct;115:105293. doi: 10.1016/j.bioorg.2021.105293. Epub 2021 Aug 20.

For unmet clinical needs, a novel class of ethacrynic acid (EA) derivatives containing triazole moieties (3a-i and 8) were designed, synthesized and evaluated as new anticancer agents. The in vitro anti-proliferative activities were assessed first on HL60 cell line...

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El Abbouchi A, El Brahmi N, Hiebel MA, et al. Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents. Bioorg Chem. 2021;115:105293doi: 10.1016/j.bioorg.2021.105293.
El Abbouchi, A., El Brahmi, N., Hiebel, M. A., Bignon, J., Guillaumet, G., Suzenet, F., & El Kazzouli, S. (2021). Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents. Bioorganic chemistry, 115105293. https://doi.org/10.1016/j.bioorg.2021.105293
El Abbouchi, Abdelmoula, et al. "Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents." Bioorganic chemistry vol. 115 (2021): 105293. doi: https://doi.org/10.1016/j.bioorg.2021.105293
El Abbouchi A, El Brahmi N, Hiebel MA, Bignon J, Guillaumet G, Suzenet F, El Kazzouli S. Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents. Bioorg Chem. 2021 Oct;115:105293. doi: 10.1016/j.bioorg.2021.105293. Epub 2021 Aug 20. PMID: 34426162.
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The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris.

Yeast (Chichester, England)

Luo G, Liu J, Bian T, Zhang Z, Li M.
PMID: 34486746
Yeast. 2021 Nov;38(11):601-611. doi: 10.1002/yea.3668. Epub 2021 Sep 30.

Our previous study revealed that N-acetyl-l-cysteine (NAC) could enhance the secretion of recombinant proteins by Pichia pastoris, but the corresponding molecular mechanisms are still unclear. In the present study, we explored whether other thiols have a similar action on...

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Luo G, Liu J, Bian T, et al. The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris. Yeast. 2021;38(11):601-611doi: 10.1002/yea.3668.
Luo, G., Liu, J., Bian, T., Zhang, Z., & Li, M. (2021). The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris. Yeast (Chichester, England), 38(11), 601-611. https://doi.org/10.1002/yea.3668
Luo, Gang, et al. "The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris." Yeast (Chichester, England) vol. 38,11 (2021): 601-611. doi: https://doi.org/10.1002/yea.3668
Luo G, Liu J, Bian T, Zhang Z, Li M. The mechanism of N-acetyl-l-cysteine in improving the secretion of porcine follicle-stimulating hormone in Pichia pastoris. Yeast. 2021 Nov;38(11):601-611. doi: 10.1002/yea.3668. Epub 2021 Sep 30. PMID: 34486746.
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HPLC determination of thioglycolic acid and other aliphatic thiols in cosmetic formulations using ethacrynic acid as precolumn derivatization reagent.

International journal of cosmetic science

Cavrini V, Andrisano V, Gatti R, Scapini G.
PMID: 19291042
Int J Cosmet Sci. 1990 Aug;12(4):141-50. doi: 10.1111/j.1467-2494.1990.tb00530.x.

Synopsis Limits imposed on the usage of thioglycolic acid, its salts and esters in cosmetic formulations require selective and sensitive analytical methods for their determination. In this study a convenient and reliable method based on high-performance liquid chromatography (HPLC)...

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Cavrini V, Andrisano V, Gatti R, et al. HPLC determination of thioglycolic acid and other aliphatic thiols in cosmetic formulations using ethacrynic acid as precolumn derivatization reagent. Int J Cosmet Sci. 1990;12(4):141-50doi: 10.1111/j.1467-2494.1990.tb00530.x.
Cavrini, V., Andrisano, V., Gatti, R., & Scapini, G. (1990). HPLC determination of thioglycolic acid and other aliphatic thiols in cosmetic formulations using ethacrynic acid as precolumn derivatization reagent. International journal of cosmetic science, 12(4), 141-50. https://doi.org/10.1111/j.1467-2494.1990.tb00530.x
Cavrini, V, et al. "HPLC determination of thioglycolic acid and other aliphatic thiols in cosmetic formulations using ethacrynic acid as precolumn derivatization reagent." International journal of cosmetic science vol. 12,4 (1990): 141-50. doi: https://doi.org/10.1111/j.1467-2494.1990.tb00530.x
Cavrini V, Andrisano V, Gatti R, Scapini G. HPLC determination of thioglycolic acid and other aliphatic thiols in cosmetic formulations using ethacrynic acid as precolumn derivatization reagent. Int J Cosmet Sci. 1990 Aug;12(4):141-50. doi: 10.1111/j.1467-2494.1990.tb00530.x. PMID: 19291042.
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Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes.

Experimental and clinical cardiology

Röth E, Marczin N, Balatonyi B, Ghosh S, Kovács V, Alotti N, Borsiczky B, Gasz B.
PMID: 22065940
Exp Clin Cardiol. 2011;16(3):92-6.

Oxidative stress and ischemia-reperfusion (I/R) injury are crucial in the pathogenesis of cardiovascular diseases. The antioxidant glutathione S-transferase (GST) is responsible for the high-capacity metabolic inactivation of electrophilic compounds and toxic substrates. The main objective of the present study...

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Röth E, Marczin N, Balatonyi B, et al. Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes. Exp Clin Cardiol. 2011;16(3):92-6
Röth, E., Marczin, N., Balatonyi, B., Ghosh, S., Kovács, V., Alotti, N., Borsiczky, B., & Gasz, B. (2011). Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes. Experimental and clinical cardiology, 16(3), 92-6.
Röth, E, et al. "Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes." Experimental and clinical cardiology vol. 16,3 (2011): 92-6.
Röth E, Marczin N, Balatonyi B, Ghosh S, Kovács V, Alotti N, Borsiczky B, Gasz B. Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes. Exp Clin Cardiol. 2011;16(3):92-6. PMID: 22065940; PMCID: PMC3209546.
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Review about gabapentin misuse, interactions, contraindications and side effects.

Journal of experimental pharmacology

Quintero GC.
PMID: 28223849
J Exp Pharmacol. 2017 Feb 09;9:13-21. doi: 10.2147/JEP.S124391. eCollection 2017.

The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016)....

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Quintero GC. Review about gabapentin misuse, interactions, contraindications and side effects. J Exp Pharmacol. 2017;9:13-21doi: 10.2147/JEP.S124391.
Quintero, G. C. (2017). Review about gabapentin misuse, interactions, contraindications and side effects. Journal of experimental pharmacology, 913-21. https://doi.org/10.2147/JEP.S124391
Quintero, Gabriel C. "Review about gabapentin misuse, interactions, contraindications and side effects." Journal of experimental pharmacology vol. 9 (2017): 13-21. doi: https://doi.org/10.2147/JEP.S124391
Quintero GC. Review about gabapentin misuse, interactions, contraindications and side effects. J Exp Pharmacol. 2017 Feb 09;9:13-21. doi: 10.2147/JEP.S124391. eCollection 2017. PMID: 28223849; PMCID: PMC5308580.
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Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma.

Nanomaterials (Basel, Switzerland)

Han B, Wang Y, Wang L, Shang Z, Wang S, Pei J.
PMID: 28347082
Nanomaterials (Basel). 2015 Sep 29;5(4):1571-1587. doi: 10.3390/nano5041571.

During the chemotherapy of cancer, drug resistance is the first issue that chemotherapeutic drugs cannot be effectively used for the treatment of cancers repeatedly for a long term, and the main reason for this is that tumor cell detoxification...

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Han B, Wang Y, Wang L, et al. Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma. Nanomaterials (Basel). 2015;5(4):1571-1587doi: 10.3390/nano5041571.
Han, B., Wang, Y., Wang, L., Shang, Z., Wang, S., & Pei, J. (2015). Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma. Nanomaterials (Basel, Switzerland), 5(4), 1571-1587. https://doi.org/10.3390/nano5041571
Han, Bing, et al. "Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma." Nanomaterials (Basel, Switzerland) vol. 5,4 (2015): 1571-1587. doi: https://doi.org/10.3390/nano5041571
Han B, Wang Y, Wang L, Shang Z, Wang S, Pei J. Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma. Nanomaterials (Basel). 2015 Sep 29;5(4):1571-1587. doi: 10.3390/nano5041571. PMID: 28347082; PMCID: PMC5304786.
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Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands.

Inorganic chemistry

Agonigi G, Riedel T, Zacchini S, Păunescu E, Pampaloni G, Bartalucci N, Dyson PJ, Marchetti F.
PMID: 26073654
Inorg Chem. 2015 Jul 06;54(13):6504-12. doi: 10.1021/acs.inorgchem.5b00802. Epub 2015 Jun 15.

Pyridine- and phosphine-based ligands modified with ethacrynic acid (a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)-arene complexes and to a ruthenium(III) NAMI-A type complex. All the compounds (ligands and complexes) were fully characterized by analytical...

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Agonigi G, Riedel T, Zacchini S, et al. Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands. Inorg Chem. 2015;54(13):6504-12doi: 10.1021/acs.inorgchem.5b00802.
Agonigi, G., Riedel, T., Zacchini, S., Păunescu, E., Pampaloni, G., Bartalucci, N., Dyson, P. J., & Marchetti, F. (2015). Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands. Inorganic chemistry, 54(13), 6504-12. https://doi.org/10.1021/acs.inorgchem.5b00802
Agonigi, Gabriele, et al. "Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands." Inorganic chemistry vol. 54,13 (2015): 6504-12. doi: https://doi.org/10.1021/acs.inorgchem.5b00802
Agonigi G, Riedel T, Zacchini S, Păunescu E, Pampaloni G, Bartalucci N, Dyson PJ, Marchetti F. Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands. Inorg Chem. 2015 Jul 06;54(13):6504-12. doi: 10.1021/acs.inorgchem.5b00802. Epub 2015 Jun 15. PMID: 26073654.
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Showing 13 to 24 of 39 entries