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Showing 829 to 832 of 832 entries
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Modulation of the tumor microenvironment (TME) by melatonin.

European journal of pharmacology

Mu Q, Najafi M.
PMID: 34302814
Eur J Pharmacol. 2021 Sep 15;907:174365. doi: 10.1016/j.ejphar.2021.174365. Epub 2021 Jul 21.

The tumor microenvironment (TME) includes a number of non-cancerous cells that affect cancer cell survival. Although CD8

Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.

European journal of pharmacology

Li SY, Shang J, Mao XM, Fan R, Li HQ, Li RH, Shen DY.
PMID: 34324855
Eur J Pharmacol. 2021 Oct 05;908:174370. doi: 10.1016/j.ejphar.2021.174370. Epub 2021 Jul 27.

Colorectal cancer (CRC) is the most fatal gastrointestinal tumor and it is urge to explore powerful drugs for the treatment. Diosgenin (DSG) as a new steroidal had been reported exerts anti-tumor activity in multiple cancers, including CRC. However, the...

Supplementation of taurine improves ionic homeostasis and mitochondrial function in the rats exhibiting post-traumatic stress disorder-like symptoms.

European journal of pharmacology

Bhattacharjee A, Prajapati SK, Krishnamurthy S.
PMID: 34297965
Eur J Pharmacol. 2021 Oct 05;908:174361. doi: 10.1016/j.ejphar.2021.174361. Epub 2021 Jul 21.

RATIONALE: Current pharmacotherapy for post-traumatic stress disorder (PTSD) is limited to few antidepressants. Mitochondrial dysfunction is observed in PTSD, along with altered potassium homeostasis. Nutritional supplementation of taurine can improve ionic homeostasis and thereby treat PTSD-like symptoms in rats.AIM:...

Proteomic profiling reveals antitumor effects of RT2 peptide on a human colon carcinoma xenograft mouse model.

European journal of pharmacology

Maijaroen S, Klaynongsruang S, Reabroi S, Chairoungdua A, Roytrakul S, Daduang J, Taemaitree L, Jangpromma N.
PMID: 35032485
Eur J Pharmacol. 2022 Jan 12;174753. doi: 10.1016/j.ejphar.2022.174753. Epub 2022 Jan 12.

A comparative study of human colon HCT-116 xenograft in nude mice treated with and without peptide RT2 at high doses is performed along with a label-free proteomic analysis of the tissue in order to understand the potential mechanisms by...

Showing 829 to 832 of 832 entries