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FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors.

Biochimica et biophysica acta. Reviews on cancer

Servetto A, Formisano L, Arteaga CL.
PMID: 34303787
Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188595. doi: 10.1016/j.bbcan.2021.188595. Epub 2021 Jul 23.

Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been extensively investigated in solid malignancies, representing an attractive therapeutic target. In breast cancer, especially in estrogen receptor positive (ER+) subtype, FGFR signaling aberrations have been reported to contribute to...

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Servetto A, Formisano L, Arteaga CL. FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors. Biochim Biophys Acta Rev Cancer. 2021;1876(2):188595doi: 10.1016/j.bbcan.2021.188595.
Servetto, A., Formisano, L., & Arteaga, C. L. (2021). FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors. Biochimica et biophysica acta. Reviews on cancer, 1876(2), 188595. https://doi.org/10.1016/j.bbcan.2021.188595
Servetto, Alberto, et al. "FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors." Biochimica et biophysica acta. Reviews on cancer vol. 1876,2 (2021): 188595. doi: https://doi.org/10.1016/j.bbcan.2021.188595
Servetto A, Formisano L, Arteaga CL. FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors. Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188595. doi: 10.1016/j.bbcan.2021.188595. Epub 2021 Jul 23. PMID: 34303787.
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FGF2 and FGF10 expression patterns in the epidermis and mesenchyme during homeotic transformation of tail into hindlimbs in frog tadpoles.

Acta histochemica

Hota J, Mahapatra PK.
PMID: 34968793
Acta Histochem. 2021 Dec 28;124(1):151836. doi: 10.1016/j.acthis.2021.151836. Epub 2021 Dec 28.

Limbs are trunk quintessential in tetrapods. Their development relies on the Retinoic acid (RA) gradient in association with the Fibroblast Growth Factors (FGFs). The role of various FGFs have been probed extensively and confirmed during the induction of ectopic...

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Hota J, Mahapatra PK. FGF2 and FGF10 expression patterns in the epidermis and mesenchyme during homeotic transformation of tail into hindlimbs in frog tadpoles. Acta Histochem. 2021;124(1):151836doi: 10.1016/j.acthis.2021.151836.
Hota, J., & Mahapatra, P. K. (2021). FGF2 and FGF10 expression patterns in the epidermis and mesenchyme during homeotic transformation of tail into hindlimbs in frog tadpoles. Acta histochemica, 124(1), 151836. https://doi.org/10.1016/j.acthis.2021.151836
Hota, Jutshina, and Mahapatra, Pravati Kumari. "FGF2 and FGF10 expression patterns in the epidermis and mesenchyme during homeotic transformation of tail into hindlimbs in frog tadpoles." Acta histochemica vol. 124,1 (2021): 151836. doi: https://doi.org/10.1016/j.acthis.2021.151836
Hota J, Mahapatra PK. FGF2 and FGF10 expression patterns in the epidermis and mesenchyme during homeotic transformation of tail into hindlimbs in frog tadpoles. Acta Histochem. 2021 Dec 28;124(1):151836. doi: 10.1016/j.acthis.2021.151836. Epub 2021 Dec 28. PMID: 34968793.
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Fibroblast growth factor in the treatment of burns: A systematic review.

Burns : journal of the International Society for Burn Injuries

Gragnani A, Tonarelli E, Chomiski V, Piccolo Daher R, Ferreira LM.
PMID: 33933306
Burns. 2021 Apr 14; doi: 10.1016/j.burns.2021.04.006. Epub 2021 Apr 14.

INTRODUCTION: A burn is a trauma that breaks the skin barrier, causing local and systemic responses. Treatment is complex, multiprofessional and expensive. In addition to surgical treatment, topical dressings can be used to keep the wound moist, reduce the...

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Gragnani A, Tonarelli E, Chomiski V, et al. Fibroblast growth factor in the treatment of burns: A systematic review. Burns. 2021;doi: 10.1016/j.burns.2021.04.006.
Gragnani, A., Tonarelli, E., Chomiski, V., Piccolo Daher, R., & Ferreira, L. M. (2021). Fibroblast growth factor in the treatment of burns: A systematic review. Burns : journal of the International Society for Burn Injuries, . https://doi.org/10.1016/j.burns.2021.04.006
Gragnani, A, et al. "Fibroblast growth factor in the treatment of burns: A systematic review." Burns : journal of the International Society for Burn Injuries vol. (2021). doi: https://doi.org/10.1016/j.burns.2021.04.006
Gragnani A, Tonarelli E, Chomiski V, Piccolo Daher R, Ferreira LM. Fibroblast growth factor in the treatment of burns: A systematic review. Burns. 2021 Apr 14; doi: 10.1016/j.burns.2021.04.006. Epub 2021 Apr 14. PMID: 33933306.
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Hepatokines and adipokines in NASH-related hepatocellular carcinoma.

Journal of hepatology

Kucukoglu O, Sowa JP, Mazzolini GD, Syn WK, Canbay A.
PMID: 33161047
J Hepatol. 2021 Feb;74(2):442-457. doi: 10.1016/j.jhep.2020.10.030. Epub 2020 Nov 05.

The incidence of hepatocellular carcinoma (HCC) is increasing in industrialised societies; this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD), its progressive form non-alcoholic steatohepatitis (NASH), and the metabolic syndrome. Cumulative studies suggest that...

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Kucukoglu O, Sowa JP, Mazzolini GD, et al. Hepatokines and adipokines in NASH-related hepatocellular carcinoma. J Hepatol. 2020;74(2):442-457doi: 10.1016/j.jhep.2020.10.030.
Kucukoglu, O., Sowa, J. P., Mazzolini, G. D., Syn, W. K., & Canbay, A. (2021). Hepatokines and adipokines in NASH-related hepatocellular carcinoma. Journal of hepatology, 74(2), 442-457. https://doi.org/10.1016/j.jhep.2020.10.030
Kucukoglu, Ozlem, et al. "Hepatokines and adipokines in NASH-related hepatocellular carcinoma." Journal of hepatology vol. 74,2 (2021): 442-457. doi: https://doi.org/10.1016/j.jhep.2020.10.030
Kucukoglu O, Sowa JP, Mazzolini GD, Syn WK, Canbay A. Hepatokines and adipokines in NASH-related hepatocellular carcinoma. J Hepatol. 2021 Feb;74(2):442-457. doi: 10.1016/j.jhep.2020.10.030. Epub 2020 Nov 05. PMID: 33161047.
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The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients.

Journal of clinical medicine

Kiluk P, Baran A, Kaminski TW, Maciaszek M, Flisiak I.
PMID: 31847236
J Clin Med. 2019 Dec 13;8(12). doi: 10.3390/jcm8122206.

Fibroblast growth factors 21 and 23 are used as markers of cardiometabolic disorders which are common comorbidities in psoriasis. The study aimed to evaluate the serum level of these factors in psoriatic patients and elucidate the possible interplay between...

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Kiluk P, Baran A, Kaminski TW, et al. The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients. J Clin Med. 2019;8(12)doi: 10.3390/jcm8122206.
Kiluk, P., Baran, A., Kaminski, T. W., Maciaszek, M., & Flisiak, I. (2019). The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients. Journal of clinical medicine, 8(12), . https://doi.org/10.3390/jcm8122206
Kiluk, Paulina, et al. "The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients." Journal of clinical medicine vol. 8,12 (2019). doi: https://doi.org/10.3390/jcm8122206
Kiluk P, Baran A, Kaminski TW, Maciaszek M, Flisiak I. The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients. J Clin Med. 2019 Dec 13;8(12). doi: 10.3390/jcm8122206. PMID: 31847236; PMCID: PMC6947480.
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Inhibitory Effects of Combined Bone Morphogenetic Protein 2, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor on Osteoclast Differentiation and Activity.

Tissue engineering. Part A

Wu H, Yin G, Pu X, Wang J, Liao X, Huang Z.
PMID: 33632010
Tissue Eng Part A. 2021 Nov;27(21):1387-1398. doi: 10.1089/ten.TEA.2020.0325. Epub 2021 Apr 13.

Bone morphogenetic protein 2 (BMP-2), vascular endothelial growth factor (VEGF), and basic fibroblast growth factors (bFGF) are important regulators of bone development and bone remodeling involving the coordination of osteoblast-mediated bone formation and osteoclast-mediated bone resorption. The synergistic promotions...

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Wu H, Yin G, Pu X, et al. Inhibitory Effects of Combined Bone Morphogenetic Protein 2, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor on Osteoclast Differentiation and Activity. Tissue Eng Part A. 2021;27(21):1387-1398doi: 10.1089/ten.TEA.2020.0325.
Wu, H., Yin, G., Pu, X., Wang, J., Liao, X., & Huang, Z. (2021). Inhibitory Effects of Combined Bone Morphogenetic Protein 2, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor on Osteoclast Differentiation and Activity. Tissue engineering. Part A, 27(21), 1387-1398. https://doi.org/10.1089/ten.TEA.2020.0325
Wu, Huan, et al. "Inhibitory Effects of Combined Bone Morphogenetic Protein 2, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor on Osteoclast Differentiation and Activity." Tissue engineering. Part A vol. 27,21 (2021): 1387-1398. doi: https://doi.org/10.1089/ten.TEA.2020.0325
Wu H, Yin G, Pu X, Wang J, Liao X, Huang Z. Inhibitory Effects of Combined Bone Morphogenetic Protein 2, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor on Osteoclast Differentiation and Activity. Tissue Eng Part A. 2021 Nov;27(21):1387-1398. doi: 10.1089/ten.TEA.2020.0325. Epub 2021 Apr 13. PMID: 33632010.
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Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment.

Journal of clinical medicine

Porębska N, Latko M, Kucińska M, Zakrzewska M, Otlewski J, Opaliński Ł.
PMID: 30577533
J Clin Med. 2018 Dec 20;8(1). doi: 10.3390/jcm8010007.

Fibroblast growth factor receptors (FGFRs) in response to fibroblast growth factors (FGFs) transmit signals across the cell membrane, regulating important cellular processes, like differentiation, division, motility, and death. The aberrant activity of FGFRs is often observed in various diseases,...

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Porębska N, Latko M, Kucińska M, et al. Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment. J Clin Med. 2018;8(1)doi: 10.3390/jcm8010007.
Porębska, N., Latko, M., Kucińska, M., Zakrzewska, M., Otlewski, J., & Opaliński, �. �. (2018). Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment. Journal of clinical medicine, 8(1), . https://doi.org/10.3390/jcm8010007
Porębska, Natalia, et al. "Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment." Journal of clinical medicine vol. 8,1 (2018). doi: https://doi.org/10.3390/jcm8010007
Porębska N, Latko M, Kucińska M, Zakrzewska M, Otlewski J, Opaliński Ł. Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment. J Clin Med. 2018 Dec 20;8(1). doi: 10.3390/jcm8010007. PMID: 30577533; PMCID: PMC6352210.
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Evaluation of fibroblast growth factor-2 on the proliferation of osteogenic potential and protein expression of stem cell spheroids composed of stem cells derived from bone marrow.

Experimental and therapeutic medicine

Tae JY, Ko Y, Park JB.
PMID: 31258669
Exp Ther Med. 2019 Jul;18(1):326-331. doi: 10.3892/etm.2019.7543. Epub 2019 May 03.

Fibroblast growth factor-2 (FGF-2) is reported to have various functions and is considered a key human mesenchymal stem cell mitogen, often supplemented to increase human mesenchymal stem cell growth rates. The purpose of this study was to evaluate the...

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Tae JY, Ko Y, Park JB. Evaluation of fibroblast growth factor-2 on the proliferation of osteogenic potential and protein expression of stem cell spheroids composed of stem cells derived from bone marrow. Exp Ther Med. 2019;18(1):326-331doi: 10.3892/etm.2019.7543.
Tae, J. Y., Ko, Y., & Park, J. B. (2019). Evaluation of fibroblast growth factor-2 on the proliferation of osteogenic potential and protein expression of stem cell spheroids composed of stem cells derived from bone marrow. Experimental and therapeutic medicine, 18(1), 326-331. https://doi.org/10.3892/etm.2019.7543
Tae, Jae-Yong, et al. "Evaluation of fibroblast growth factor-2 on the proliferation of osteogenic potential and protein expression of stem cell spheroids composed of stem cells derived from bone marrow." Experimental and therapeutic medicine vol. 18,1 (2019): 326-331. doi: https://doi.org/10.3892/etm.2019.7543
Tae JY, Ko Y, Park JB. Evaluation of fibroblast growth factor-2 on the proliferation of osteogenic potential and protein expression of stem cell spheroids composed of stem cells derived from bone marrow. Exp Ther Med. 2019 Jul;18(1):326-331. doi: 10.3892/etm.2019.7543. Epub 2019 May 03. PMID: 31258669; PMCID: PMC6566042.
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Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs.

Stem cells international

Boddy SL, Romero-Guevara R, Ji AR, Unger C, Corns L, Marcotti W, Rivolta MN.
PMID: 32190057
Stem Cells Int. 2020 Mar 01;2020:3692937. doi: 10.1155/2020/3692937. eCollection 2020.

Damage to the sensory hair cells and the spiral ganglion neurons of the cochlea leads to deafness. Induced pluripotent stem cells (iPSCs) are a promising tool to regenerate the cells in the inner ear that have been affected by...

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Boddy SL, Romero-Guevara R, Ji AR, et al. Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs. Stem Cells Int. 2020;2020:3692937doi: 10.1155/2020/3692937.
Boddy, S. L., Romero-Guevara, R., Ji, A. R., Unger, C., Corns, L., Marcotti, W., & Rivolta, M. N. (2020). Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs. Stem cells international, 20203692937. https://doi.org/10.1155/2020/3692937
Boddy, Sarah L, et al. "Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs." Stem cells international vol. 2020 (2020): 3692937. doi: https://doi.org/10.1155/2020/3692937
Boddy SL, Romero-Guevara R, Ji AR, Unger C, Corns L, Marcotti W, Rivolta MN. Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs. Stem Cells Int. 2020 Mar 01;2020:3692937. doi: 10.1155/2020/3692937. eCollection 2020. PMID: 32190057; PMCID: PMC7068143.
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A designed fusion tag for soluble expression and selective separation of extracellular domains of fibroblast growth factor receptors.

Scientific reports

Cheong DE, Choi HJ, Yoo SK, Lee HD, Kim GJ.
PMID: 34728710
Sci Rep. 2021 Nov 02;11(1):21453. doi: 10.1038/s41598-021-01029-4.

Fibroblast growth factor receptors (FGFRs) generate various transduction signals by interaction with fibroblast growth factors (FGFs) and are involved in various biological functions such as cell proliferation, migration, and differentiation. Malfunction of these proteins may lead to the development...

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Cheong DE, Choi HJ, Yoo SK, et al. A designed fusion tag for soluble expression and selective separation of extracellular domains of fibroblast growth factor receptors. Sci Rep. 2021;11(1):21453doi: 10.1038/s41598-021-01029-4.
Cheong, D. E., Choi, H. J., Yoo, S. K., Lee, H. D., & Kim, G. J. (2021). A designed fusion tag for soluble expression and selective separation of extracellular domains of fibroblast growth factor receptors. Scientific reports, 11(1), 21453. https://doi.org/10.1038/s41598-021-01029-4
Cheong, Dae-Eun, et al. "A designed fusion tag for soluble expression and selective separation of extracellular domains of fibroblast growth factor receptors." Scientific reports vol. 11,1 (2021): 21453. doi: https://doi.org/10.1038/s41598-021-01029-4
Cheong DE, Choi HJ, Yoo SK, Lee HD, Kim GJ. A designed fusion tag for soluble expression and selective separation of extracellular domains of fibroblast growth factor receptors. Sci Rep. 2021 Nov 02;11(1):21453. doi: 10.1038/s41598-021-01029-4. PMID: 34728710; PMCID: PMC8563715.
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sox19 regulates ovarian steroidogenesis in common carp.

The Journal of steroid biochemistry and molecular biology

Anitha A, Senthilkumaran B.
PMID: 34915169
J Steroid Biochem Mol Biol. 2021 Dec 13;217:106044. doi: 10.1016/j.jsbmb.2021.106044. Epub 2021 Dec 13.

In teleost, ovarian steroidogenesis governed by the neuroendocrine system is also regulated by several transcription factors of gonadal origin. Investigating the synchronized interactions between the transcriptional and the hormonal factors is vital to comprehend the mechanisms that lead to...

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Anitha A, Senthilkumaran B. sox19 regulates ovarian steroidogenesis in common carp. J Steroid Biochem Mol Biol. 2021;217:106044doi: 10.1016/j.jsbmb.2021.106044.
Anitha, A., & Senthilkumaran, B. (2021). sox19 regulates ovarian steroidogenesis in common carp. The Journal of steroid biochemistry and molecular biology, 217106044. https://doi.org/10.1016/j.jsbmb.2021.106044
Anitha, Arumugam, and Senthilkumaran, Balasubramanian. "sox19 regulates ovarian steroidogenesis in common carp." The Journal of steroid biochemistry and molecular biology vol. 217 (2021): 106044. doi: https://doi.org/10.1016/j.jsbmb.2021.106044
Anitha A, Senthilkumaran B. sox19 regulates ovarian steroidogenesis in common carp. J Steroid Biochem Mol Biol. 2021 Dec 13;217:106044. doi: 10.1016/j.jsbmb.2021.106044. Epub 2021 Dec 13. PMID: 34915169.
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An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness.

Frontiers in cell and developmental biology

Quan MY, Guo Q, Liu J, Yang R, Bai J, Wang W, Cai Y, Han R, Lv YQ, Ding L, Billadeau DD, Lou Z, Bellusci S, Li X, Zhang JS.
PMID: 32457900
Front Cell Dev Biol. 2020 May 07;8:287. doi: 10.3389/fcell.2020.00287. eCollection 2020.

Cancer stemness is associated with high malignancy and low differentiation, as well as therapeutic resistance of tumors including pancreatic ductal adenocarcinoma (PDAC). Fibroblast growth factors (FGFs) exert pleiotropic effects on a variety of cellular processes and functions including embryonic...

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Quan MY, Guo Q, Liu J, et al. An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness. Front Cell Dev Biol. 2020;8:287doi: 10.3389/fcell.2020.00287.
Quan, M. Y., Guo, Q., Liu, J., Yang, R., Bai, J., Wang, W., Cai, Y., Han, R., Lv, Y. Q., Ding, L., Billadeau, D. D., Lou, Z., Bellusci, S., Li, X., & Zhang, J. S. (2020). An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness. Frontiers in cell and developmental biology, 8287. https://doi.org/10.3389/fcell.2020.00287
Quan, Mei-Yu, et al. "An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness." Frontiers in cell and developmental biology vol. 8 (2020): 287. doi: https://doi.org/10.3389/fcell.2020.00287
Quan MY, Guo Q, Liu J, Yang R, Bai J, Wang W, Cai Y, Han R, Lv YQ, Ding L, Billadeau DD, Lou Z, Bellusci S, Li X, Zhang JS. An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness. Front Cell Dev Biol. 2020 May 07;8:287. doi: 10.3389/fcell.2020.00287. eCollection 2020. PMID: 32457900; PMCID: PMC7221133.
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Showing 25 to 36 of 200 entries