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Showing 13 to 24 of 96 entries
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The emerging roles of srGAPs in cancer.

Molecular biology reports

Ji V, Kishore C.
PMID: 34825319
Mol Biol Rep. 2021 Nov 25; doi: 10.1007/s11033-021-06872-2. Epub 2021 Nov 25.

GTPase activating proteins (GAPs) were initially considered as the inhibitors of cell signaling pathways because of their nature to activate the intrinsic GTPase activity of the RhoGTPases. But recent studies of dysregulated GAPs in many cancers such as glioblastoma,...

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Ji V, Kishore C. The emerging roles of srGAPs in cancer. Mol Biol Rep. 2021;doi: 10.1007/s11033-021-06872-2.
Ji, V., & Kishore, C. (2021). The emerging roles of srGAPs in cancer. Molecular biology reports, . https://doi.org/10.1007/s11033-021-06872-2
Ji, Vaishali, and Kishore, Chandra. "The emerging roles of srGAPs in cancer." Molecular biology reports vol. (2021). doi: https://doi.org/10.1007/s11033-021-06872-2
Ji V, Kishore C. The emerging roles of srGAPs in cancer. Mol Biol Rep. 2021 Nov 25; doi: 10.1007/s11033-021-06872-2. Epub 2021 Nov 25. PMID: 34825319.
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Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases.

Frontiers in cell and developmental biology

Lei Z, Wang J, Zhang L, Liu CH.
PMID: 34277632
Front Cell Dev Biol. 2021 Jul 01;9:688352. doi: 10.3389/fcell.2021.688352. eCollection 2021.

Membrane trafficking is critical for cellular homeostasis, which is mainly carried out by small GTPases, a class of proteins functioning in vesicle budding, transport, tethering and fusion processes. The accurate and organized membrane trafficking relies on the proper regulation...

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Lei Z, Wang J, Zhang L, et al. Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases. Front Cell Dev Biol. 2021;9:688352doi: 10.3389/fcell.2021.688352.
Lei, Z., Wang, J., Zhang, L., & Liu, C. H. (2021). Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases. Frontiers in cell and developmental biology, 9688352. https://doi.org/10.3389/fcell.2021.688352
Lei, Zehui, et al. "Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases." Frontiers in cell and developmental biology vol. 9 (2021): 688352. doi: https://doi.org/10.3389/fcell.2021.688352
Lei Z, Wang J, Zhang L, Liu CH. Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases. Front Cell Dev Biol. 2021 Jul 01;9:688352. doi: 10.3389/fcell.2021.688352. eCollection 2021. PMID: 34277632; PMCID: PMC8281112.
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Bioinformatics analysis of potential therapeutic targets among .

Oncology letters

Chen WX, Lou M, Cheng L, Qian Q, Xu LY, Sun L, Zhu YL, Dai H.
PMID: 31788076
Oncol Lett. 2019 Dec;18(6):6017-6025. doi: 10.3892/ol.2019.10949. Epub 2019 Oct 02.

GTPase activating proteins (RhoGAPs) serve significant roles in multiple aspects of tumor biology. Genes encoding RhoGAPs (

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Chen WX, Lou M, Cheng L, et al. Bioinformatics analysis of potential therapeutic targets among . Oncol Lett. 2019;18(6):6017-6025doi: 10.3892/ol.2019.10949.
Chen, W. X., Lou, M., Cheng, L., Qian, Q., Xu, L. Y., Sun, L., Zhu, Y. L., & Dai, H. (2019). Bioinformatics analysis of potential therapeutic targets among . Oncology letters, 18(6), 6017-6025. https://doi.org/10.3892/ol.2019.10949
Chen, Wei-Xian, et al. "Bioinformatics analysis of potential therapeutic targets among ." Oncology letters vol. 18,6 (2019): 6017-6025. doi: https://doi.org/10.3892/ol.2019.10949
Chen WX, Lou M, Cheng L, Qian Q, Xu LY, Sun L, Zhu YL, Dai H. Bioinformatics analysis of potential therapeutic targets among . Oncol Lett. 2019 Dec;18(6):6017-6025. doi: 10.3892/ol.2019.10949. Epub 2019 Oct 02. PMID: 31788076; PMCID: PMC6864933.
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Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury.

Cell discovery

Cho CS, Kowalsky AH, Namkoong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy MA, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, Lee JH.
PMID: 31754457
Cell Discov. 2019 Nov 19;5:60. doi: 10.1038/s41421-019-0131-9. eCollection 2019.

mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated...

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Cho CS, Kowalsky AH, Namkoong S, et al. Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury. Cell Discov. 2019;5:60doi: 10.1038/s41421-019-0131-9.
Cho, C. S., Kowalsky, A. H., Namkoong, S., Park, S. R., Wu, S., Kim, B., James, A., Gu, B., Semple, I. A., Tohamy, M. A., Solanki, S., Cho, U. S., Greenson, J. K., Shah, Y. M., Kim, M., & Lee, J. H. (2019). Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury. Cell discovery, 560. https://doi.org/10.1038/s41421-019-0131-9
Cho, Chun-Seok, et al. "Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury." Cell discovery vol. 5 (2019): 60. doi: https://doi.org/10.1038/s41421-019-0131-9
Cho CS, Kowalsky AH, Namkoong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy MA, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, Lee JH. Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury. Cell Discov. 2019 Nov 19;5:60. doi: 10.1038/s41421-019-0131-9. eCollection 2019. PMID: 31754457; PMCID: PMC6868011.
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High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins.

Methods in molecular biology (Clifton, N.J.)

Mishra AK, Lambright DG.
PMID: 34453708
Methods Mol Biol. 2021;2293:27-43. doi: 10.1007/978-1-0716-1346-7_3.

Measurement of intrinsic as well as GTPase-activating Protein (GAP) catalyzed GTP hydrolysis is central to understanding the molecular mechanism and function of GTPases in diverse cellular processes. For the Rab GTPase family, which comprises at least 60 distinct proteins...

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Mishra AK, Lambright DG. High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins. Methods Mol Biol. 2021;2293:27-43doi: 10.1007/978-1-0716-1346-7_3.
Mishra, A. K., & Lambright, D. G. (2021). High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins. Methods in molecular biology (Clifton, N.J.), 229327-43. https://doi.org/10.1007/978-1-0716-1346-7_3
Mishra, Ashwini K, and Lambright, David G. "High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins." Methods in molecular biology (Clifton, N.J.) vol. 2293 (2021): 27-43. doi: https://doi.org/10.1007/978-1-0716-1346-7_3
Mishra AK, Lambright DG. High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins. Methods Mol Biol. 2021;2293:27-43. doi: 10.1007/978-1-0716-1346-7_3. PMID: 34453708.
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The tumor suppressive roles of ARHGAP25 in lung cancer cells.

OncoTargets and therapy

Xu K, Liu B, Ma Y.
PMID: 31692494
Onco Targets Ther. 2019 Aug 19;12:6699-6710. doi: 10.2147/OTT.S207540. eCollection 2019.

AIM: Several Rho GTPase-activating proteins (Rho GAPs) have been proved to serve as tumor suppressors in diverse human cancers. Among them, ARHGAP25 has also been found to be associated with hematopoietic cells and regulate phagocytosis. Little is known about...

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Xu K, Liu B, Ma Y. The tumor suppressive roles of ARHGAP25 in lung cancer cells. Onco Targets Ther. 2019;12:6699-6710doi: 10.2147/OTT.S207540.
Xu, K., Liu, B., & Ma, Y. (2019). The tumor suppressive roles of ARHGAP25 in lung cancer cells. OncoTargets and therapy, 126699-6710. https://doi.org/10.2147/OTT.S207540
Xu, Ke, et al. "The tumor suppressive roles of ARHGAP25 in lung cancer cells." OncoTargets and therapy vol. 12 (2019): 6699-6710. doi: https://doi.org/10.2147/OTT.S207540
Xu K, Liu B, Ma Y. The tumor suppressive roles of ARHGAP25 in lung cancer cells. Onco Targets Ther. 2019 Aug 19;12:6699-6710. doi: 10.2147/OTT.S207540. eCollection 2019. PMID: 31692494; PMCID: PMC6707938.
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Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell.

Biochemical pharmacology

Kowluru A, Gleason NF.
PMID: 34968495
Biochem Pharmacol. 2021 Dec 28;197:114886. doi: 10.1016/j.bcp.2021.114886. Epub 2021 Dec 28.

Rho subfamily of G proteins (e.g., Rac1) have been implicated in glucose-stimulated insulin secretion from the pancreatic β-cell. Interestingly, metabolic stress (e.g., chronic exposure to high glucose) results in sustained activation of Rac1 leading to increased oxidative stress, impaired...

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Kowluru A, Gleason NF. Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochem Pharmacol. 2021;197:114886doi: 10.1016/j.bcp.2021.114886.
Kowluru, A., & Gleason, N. F. (2021). Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochemical pharmacology, 197114886. https://doi.org/10.1016/j.bcp.2021.114886
Kowluru, Anjaneyulu, and Gleason, Noah F. "Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell." Biochemical pharmacology vol. 197 (2021): 114886. doi: https://doi.org/10.1016/j.bcp.2021.114886
Kowluru A, Gleason NF. Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochem Pharmacol. 2021 Dec 28;197:114886. doi: 10.1016/j.bcp.2021.114886. Epub 2021 Dec 28. PMID: 34968495.
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Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor.

Biology open

Watanabe A, Hataida H, Inoue N, Kamon K, Baba K, Sasaki K, Kimura R, Sasaki H, Eura Y, Ni WF, Shibasaki Y, Waguri S, Kokame K, Shiba Y.
PMID: 34369554
Biol Open. 2021 Sep 15;10(9). doi: 10.1242/bio.058789. Epub 2021 Sep 01.

Arf GTPase-Activating proteins (ArfGAPs) mediate the hydrolysis of GTP bound to ADP-ribosylation factors (Arfs), which are critical to form transport intermediates. ArfGAPs have been thought to be negative regulators of Arfs; however, accumulating evidence indicates that ArfGAPs are important...

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Watanabe A, Hataida H, Inoue N, et al. Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor. Biol Open. 2021;10(9)doi: 10.1242/bio.058789.
Watanabe, A., Hataida, H., Inoue, N., Kamon, K., Baba, K., Sasaki, K., Kimura, R., Sasaki, H., Eura, Y., Ni, W. F., Shibasaki, Y., Waguri, S., Kokame, K., & Shiba, Y. (2021). Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor. Biology open, 10(9), . https://doi.org/10.1242/bio.058789
Watanabe, Asano, et al. "Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor." Biology open vol. 10,9 (2021). doi: https://doi.org/10.1242/bio.058789
Watanabe A, Hataida H, Inoue N, Kamon K, Baba K, Sasaki K, Kimura R, Sasaki H, Eura Y, Ni WF, Shibasaki Y, Waguri S, Kokame K, Shiba Y. Arf GTPase-activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor. Biol Open. 2021 Sep 15;10(9). doi: 10.1242/bio.058789. Epub 2021 Sep 01. PMID: 34369554; PMCID: PMC8430232.
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Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins.

Computational and structural biotechnology journal

Wang Y, Ji D, Lei C, Chen Y, Qiu Y, Li X, Li M, Ni D, Pu J, Zhang J, Fu Q, Liu Y, Lu S.
PMID: 33680360
Comput Struct Biotechnol J. 2021 Feb 09;19:1184-1199. doi: 10.1016/j.csbj.2021.01.044. eCollection 2021.

Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the activities of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (SOS). Oncogenic Ras mutations could...

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Wang Y, Ji D, Lei C, et al. Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. Comput Struct Biotechnol J. 2021;19:1184-1199doi: 10.1016/j.csbj.2021.01.044.
Wang, Y., Ji, D., Lei, C., Chen, Y., Qiu, Y., Li, X., Li, M., Ni, D., Pu, J., Zhang, J., Fu, Q., Liu, Y., & Lu, S. (2021). Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. Computational and structural biotechnology journal, 191184-1199. https://doi.org/10.1016/j.csbj.2021.01.044
Wang, Yuanhao, et al. "Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins." Computational and structural biotechnology journal vol. 19 (2021): 1184-1199. doi: https://doi.org/10.1016/j.csbj.2021.01.044
Wang Y, Ji D, Lei C, Chen Y, Qiu Y, Li X, Li M, Ni D, Pu J, Zhang J, Fu Q, Liu Y, Lu S. Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. Comput Struct Biotechnol J. 2021 Feb 09;19:1184-1199. doi: 10.1016/j.csbj.2021.01.044. eCollection 2021. PMID: 33680360; PMCID: PMC7902900.
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Selectivity Determinants of RHO GTPase Binding to IQGAPs.

International journal of molecular sciences

Mosaddeghzadeh N, Nouri K, Krumbach OHF, Amin E, Dvorsky R, Ahmadian MR.
PMID: 34830479
Int J Mol Sci. 2021 Nov 22;22(22). doi: 10.3390/ijms222212596.

IQ motif-containing GTPase-activating proteins (IQGAPs) modulate a wide range of cellular processes by acting as scaffolds and driving protein components into distinct signaling networks. Their functional states have been proposed to be controlled by members of the RHO family...

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Mosaddeghzadeh N, Nouri K, Krumbach OHF, et al. Selectivity Determinants of RHO GTPase Binding to IQGAPs. Int J Mol Sci. 2021;22(22)doi: 10.3390/ijms222212596.
Mosaddeghzadeh, N., Nouri, K., Krumbach, O. H. F., Amin, E., Dvorsky, R., & Ahmadian, M. R. (2021). Selectivity Determinants of RHO GTPase Binding to IQGAPs. International journal of molecular sciences, 22(22), . https://doi.org/10.3390/ijms222212596
Mosaddeghzadeh, Niloufar, et al. "Selectivity Determinants of RHO GTPase Binding to IQGAPs." International journal of molecular sciences vol. 22,22 (2021). doi: https://doi.org/10.3390/ijms222212596
Mosaddeghzadeh N, Nouri K, Krumbach OHF, Amin E, Dvorsky R, Ahmadian MR. Selectivity Determinants of RHO GTPase Binding to IQGAPs. Int J Mol Sci. 2021 Nov 22;22(22). doi: 10.3390/ijms222212596. PMID: 34830479; PMCID: PMC8625570.
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A permissive function of phosphoinositide 3-kinase in ras activation mediated by inhibition of GTPase-activating proteins.

Current biology : CB

Rubio I, Wetzker R.
PMID: 11114541
Curr Biol. 2000 Nov 30;10(23):R883. doi: 10.1016/s0960-9822(00)00842-3.

No abstract available.

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Rubio I, Wetzker R. A permissive function of phosphoinositide 3-kinase in ras activation mediated by inhibition of GTPase-activating proteins. Curr Biol. 2000;10(23):R883doi: 10.1016/s0960-9822(00)00842-3.
Rubio, I., & Wetzker, R. (2000). A permissive function of phosphoinositide 3-kinase in ras activation mediated by inhibition of GTPase-activating proteins. Current biology : CB, 10(23), R883. https://doi.org/10.1016/s0960-9822(00)00842-3
Rubio, and Wetzker. "A permissive function of phosphoinositide 3-kinase in ras activation mediated by inhibition of GTPase-activating proteins." Current biology : CB vol. 10,23 (2000): R883. doi: https://doi.org/10.1016/s0960-9822(00)00842-3
Rubio I, Wetzker R. A permissive function of phosphoinositide 3-kinase in ras activation mediated by inhibition of GTPase-activating proteins. Curr Biol. 2000 Nov 30;10(23):R883. doi: 10.1016/s0960-9822(00)00842-3. PMID: 11114541.
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Advantages and limitations of cell-based assays for GTPase activation and regulation.

Cellular logistics

Casanova JE.
PMID: 23181197
Cell Logist. 2012 Jul 01;2(3):147-150. doi: 10.4161/cl.22045.

Small GTPases of the Ras superfamily are important regulators of many cellular functions, including signal transduction, cytoskeleton assembly, metabolic regulation, organelle biogenesis and intracellular transport. Most GTPases act as binary switches, being "on" in the active, GTP-bound state and...

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Casanova JE. Advantages and limitations of cell-based assays for GTPase activation and regulation. Cell Logist. 2012;2(3):147-150doi: 10.4161/cl.22045.
Casanova, J. E. (2012). Advantages and limitations of cell-based assays for GTPase activation and regulation. Cellular logistics, 2(3), 147-150. https://doi.org/10.4161/cl.22045
Casanova, James E. "Advantages and limitations of cell-based assays for GTPase activation and regulation." Cellular logistics vol. 2,3 (2012): 147-150. doi: https://doi.org/10.4161/cl.22045
Casanova JE. Advantages and limitations of cell-based assays for GTPase activation and regulation. Cell Logist. 2012 Jul 01;2(3):147-150. doi: 10.4161/cl.22045. PMID: 23181197; PMCID: PMC3498073.
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Showing 13 to 24 of 96 entries